Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure provides an article. In an embodiment, the article includes (A) a top layer composed of a composition composed of (i) from 51 wt % to 90 wt % of a propylene-based polymer, and (ii) from 10 wt % to 49 wt % of an ethylene/octene multi-block copolymer having hard segments and soft segments. The ethylene/octene multi-block copolymer has a soft segment melt temperature (SS-Tm) less than 2° C. The article also includes (B) a bottom layer composed of a textile.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for in-process adjustment to crushing systems.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for characterization of aggregate particles. A method includes obtaining, from a set of low fidelity sensors, first sensor data of a first portion of particles; obtaining, from a set of high fidelity sensors, second sensor data of the first portion of particles, the second sensor data comprising a higher fidelity representation of characteristics of the first portion of particles than the first sensor data; training a characterization model using the first sensor data and the second sensor data, the training comprising: providing, as training data to the characterization model, the second sensor data; and processing the second sensor data with the characterization model to correlate the first sensor data with the second sensor data. The first sensor data can indicate shape characteristics of each particle; and the second sensor data indicates a surface area of each particle.

Abstract: The present disclosure is directed to polypeptides, such as polypeptides comprising an alkaline phosphatase and a bone-targeting moiety. Also disclosed are expression vectors, such as lentiviral expression vectors, including a nucleotide sequence encoding a polypeptide. Also disclosed are methods of treating hypophosphatasia or treating, mitigating, or preventing one or more symptoms of hypophosphatasia by administering to a subject in need of treatment thereof the disclosed polypeptides or host cells transduced to express any of the disclosed polypeptides.

Abstract: Resource provisioning systems and methods are described. In an embodiment, a system includes a plurality of shared storage devices collectively storing database data, an execution platform, and a compute service manager. The compute service manager is configured to determine a task to be executed in response to a trigger event and determine a query plan for executing the task, wherein the query plan comprises a plurality of discrete subtasks. The compute service manager is further configured to assign the plurality of discrete subtasks to one or more nodes of a plurality of nodes of the execution platform, determine whether execution of the task is complete, and in response to determining the execution of the task is complete, store a record in the plurality of shared storage devices indicating the task was completed.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: A method and apparatus is disclosed by which a device in a wireless network may determine and reduce interference when using channels in restricted frequency bands and when other networks may be transmitting in the same restricted frequency. The wireless network may be a Wi-Fi system utilizing channels/frequencies in the television white space. Receivers, such as a client device and access point (AP), may determine information on one or more interfering signals and utilize the information to reduce or cancel the interference caused by the interfering signals generated by a second network. The information may be parameters or information on the structure of the interfering signal, and may be determined by retrieving stored cache information, receiving information on a beacon signal or sampling an interfering signal. The interference cancellation may be performed by joint demodulation or parallel interference cancellation.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: A method and apparatus is disclosed by which a device in a wireless network may determine and reduce interference when using channels in restricted frequency bands and when other networks may be transmitting in the same restricted frequency. The wireless network may be a Wi-Fi system utilizing channels/frequencies in the television white space. Receivers, such as a client device and access point (AP), may determine information on one or more interfering signals and utilize the information to reduce or cancel the interference caused by the interfering signals generated by a second network. The information may be parameters or information on the structure of the interfering signal, and may be determined by retrieving stored cache information, receiving information on a beacon signal or sampling an interfering signal. The interference cancellation may be performed by joint demodulation or parallel interference cancellation.

Abstract: Devices for labeling and discharging a contaminated fluid, and discharging a contaminant to prevent a contaminated fluid from being used. In an embodiment, a discharging device includes a wax sealing an aperture at the bottom of a water bottle. The wax melts at a high temperature which may cause the water in the bottle contaminated, releasing the water from the water bottle. In another embodiment, a discharging device including an aperture in a DEF tank and a seal material sealing the aperture is used to discharge mistakenly filled contaminant, which dissolves the seal material. In another embodiment, a labeling device including an ink sealed in a wax wrapper is disclosed. The wax wrapper melts at high temperature, releasing the ink and labeling a fluid as problematic. By using a conductive ink with a non-conductive fluid, the labeling device can also be used for detecting and recording high temperature events.