Abstract: Delivery devices and vascular devices are described for addressing a target site within a body lumen. The delivery device includes one or more ultrasound transducers positioned to transmit and receive ultrasound signals so as to provide an image of an interior of the patient's blood vessel within which the vascular device is disposed in real time, as the procedure is taking place. Using the images provided by the ultrasound transducers, the longitudinal and rotational position of the delivery device (and the vascular device constrained therein) may be adjusted to align the vascular device with the patient's vasculature. In some examples, the vascular device being delivered includes fenestrations, whereas in others the vascular device integral branch grafts.

Abstract: Vascular endografts and methods of making and using the same are provided. The vascular endograft includes an elongated body defining a lumen configured to allow blood to flow therethrough and further defining an exterior surface, and a plurality of bristles extending outwardly from the exterior surface of the elongated body. In an instance in which the endograft is positioned within a blood vessel at a location corresponding to a blood vessel pathology, the bristles encourage positive remodeling of the blood vessel.

Abstract: Cannulas for apical cannulation and methods of making and using the same are provided. The cannula includes a first elongated body defining a primary lumen, a second elongated body defining a first secondary lumen, a third elongated body defining a second secondary lumen, and a fourth elongated body defining a third secondary lumen. The primary lumen is configured to allow blood to flow therethrough. The first secondary lumen is configured to inflate an inflatable body, which is configured to engage an aortal wall proximate the aortic valve of the patient's heart to define a treatment space. The second secondary lumen is configured to selectively remove blood from the treatment space or introduce a cardioplegic solution into the treatment space. The third secondary lumen is configured to administer active decompression of the left ventricle of the patient's heart via suction.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to attach to one or more portions of a bone. An exemplary bone fixation implant includes a two-dimensional structure comprising a bone-engaging surface and a tissue-engaging surface. A plurality of openings is defined in the two-dimensional structure, and arranged across a length and a width of the bone fixation implant. At least some of openings are configured to receive an attachment member for securing the bone fixation implant to an underlying bone structure. The tissue-engaging surface is configured to engage an overlying tissue structure for encouraging incorporation of the tissue structure into the bone fixation implant to promote stabilization of the underlying bone structure during healing. In certain embodiments, at least 50% of the area defined by and/or between the length and the width of the two-dimensional structure is an opening.

Abstract: A device (100) for supporting a valve annulus is described that includes spaced apart support members (105) and a connecting member (110) extending between and connecting the support members. At least one adjustor (115) is also provided that is engaged with the connecting member and can be actuated to modify a length of the connecting member between two adjacent support members. In addition, each support member may include at least two channels extending through the support members at different heights with respect to an overall thickness of the respective support member. Each channel may receive a portion of the connecting member therethrough, and each support member may further include a passageway between the channels to allow selection of one of the channels. In this way, the device may be adjusted in at least two dimensions to support the valve leaflets and promote sufficient closure of the leaflets.

Abstract: Vascular devices and methods for addressing pathologies in the hemiarch of the aorta are provided. The device includes a main body and a secondary body. The main body has ends that are designed to be connected to corresponding ends of the native blood vessel. The secondary body has a free end and a fixed end that is engaged with an inner surface of the main body. The vascular device is movable from a retracted configuration, in which the secondary body is at least partially contained within the main body and the free end is on a proximal side of the fixed end, to an extended configuration, in which the secondary body is extended distally from the main body and the free end is on a distal side of the fixed end to address defects in the aorta downstream of the hemiarch.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to attach to one or more portions of a bone. An exemplary bone fixation implant includes a two-dimensional structure comprising a bone-engaging surface and a tissue-engaging surface. A plurality of openings is defined in the two-dimensional structure, and arranged across a length and a width of the bone fixation implant. At least some of openings are configured to receive an attachment member for securing the bone fixation implant to an underlying bone structure. The tissue-engaging surface is configured to engage an overlying tissue structure for encouraging incorporation of the tissue structure into the bone fixation implant to promote stabilization of the underlying bone structure during healing. In certain embodiments, at least 50% of the area defined by and/or between the length and the width of the two-dimensional structure is an opening.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to be attached to one or more portions of bone. The bone fixation implant may include at least one structural portion (e.g., a wire, plate, mesh, etc.) that includes metal and a polymer body at least partially surrounding the at least one structural portion. The polymer body may define an engaging surface that is configured to engage an attachment member that is applied to the bone fixation implant to fix the bone fixation implant to the bone, such that direct contact between the metal of the structural portion and the attachment member is prevented. Overlying muscle and tissue may be secured to the bone fixation implant to encourage incorporation of the tissue structure into the implant and promote stabilization and healing.

Abstract: Delivery devices and vascular devices are described for addressing a target site within a body lumen. The delivery device includes one or more ultrasound transducers positioned to transmit and receive ultrasound signals so as to provide an image of an interior of the patient's blood vessel within which the vascular device is disposed in real time, as the procedure is taking place. Using the images provided by the ultrasound transducers, the longitudinal and rotational position of the delivery device (and the vascular device constrained therein) may be adjusted to align the vascular device with the patient's vasculature. In some examples, the vascular device being delivered includes fenestrations, whereas in others the vascular device integral branch grafts.

Abstract: Delivery devices and vascular devices are described for addressing a target site within a body lumen. The delivery device includes one or more ultrasound transducers positioned to transmit and receive ultrasound signals so as to provide an image of an interior of the patient's blood vessel within which the vascular device is disposed in real time, as the procedure is taking place. Using the images provided by the ultrasound transducers, the longitudinal and rotational position of the delivery device (and the vascular device constrained therein) may be adjusted to align the vascular device with the patient's vasculature. In some examples, the vascular device being delivered includes fenestrations, whereas in others the vascular device integral branch grafts.

Abstract: Devices, systems, and methods for treating cardiac arrhythmias are disclosed. An exemplary device includes a support member having a first end and a second. At least a first pacing electrode is located proximate the first end of the support member and at least a second pacing electrode is located proximate the second end of the support member. A defibrillating electrode is located between the first pacing electrode and the second pacing electrode. An exemplary method of treating a patient comprises a device for treating cardiac arrhythmias and placing the device adjacent a heart of the patient.

Abstract: A system for supporting ribs is provided that includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member may be attached to a respective rib via fasteners such that the reinforcing member spans one or more fractures of the ribs. In addition to individually holding the portions of the rib bone together to allow the fracture to heal, however, the reinforcing members may be used on rib pairs such that closure members may be wrapped around or extended between the rib pair in an effort to stabilize the ribs. By providing extended regions configured to receive closure members, healing of the ribs may be promoted and facilitated without creating unnecessary other pain to the patient, as the rounded portions serve to keep the closure members away from the neurovascular bundles associated with the ribs.

Abstract: Vascular devices and methods for addressing aortic pathologies are provided that facilitate hemostasis at the junctions of the ends of the device with the native aorta or other vessels to minimize or eliminate the risk of endoleaks. One or both ends of the device may include inner and outer skirts that are configured to receive a section of native blood vessel therebetween. The outer skirt may be flared in some cases or rolled up prior to placement at and engagement with the blood vessel to provide clearance for joining the blood vessel to the inner skirt of the device, such as via sutures. Once engaged, the outer skirt is disposed such that the blood vessel is between the inner and outer skirts. Devices and associated methods are also described that allow endografts to be deployed and engaged with an end of the device in areas with insufficient landing zones.

Abstract: A device (100) for supporting a valve annulus is described that includes spaced apart support members (105) and a connecting member (110) extending between and connecting the support members. At least one adjustor (115) is also provided that is engaged with the connecting member and can be actuated to modify a length of the connecting member between two adjacent support members. In addition, each support member may include at least two channels extending through the support members at different heights with respect to an overall thickness of the respective support member. Each channel may receive a portion of the connecting member therethrough, and each support member may further include a passageway between the channels to allow selection of one of the channels. In this way, the device may be adjusted in at least two dimensions to support the valve leaflets and promote sufficient closure of the leaflets.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to attach to one or more portions of a bone. An exemplary bone fixation implant includes a two-dimensional structure comprising a bone-engaging surface and a tissue-engaging surface. A plurality of openings is defined in the two-dimensional structure, and arranged across a length and a width of the bone fixation implant. At least some of openings are configured to receive an attachment member for securing the bone fixation implant to an underlying bone structure. The tissue-engaging surface is configured to engage an overlying tissue structure for encouraging incorporation of the tissue structure into the bone fixation implant to promote stabilization of the underlying bone structure during healing. In certain embodiments, at least 50% of the area defined by and/or between the length and the width of the two-dimensional structure is an opening.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to be attached to one or more portions of bone. The bone fixation implant may include at least one structural portion (e.g., a wire, plate, mesh, etc.) that includes metal and a polymer body at least partially surrounding the at least one structural portion. The polymer body may define an engaging surface that is configured to engage an attachment member that is applied to the bone fixation implant to fix the bone fixation implant to the bone, such that direct contact between the metal of the structural portion and the attachment member is prevented. Overlying muscle and tissue may be secured to the bone fixation implant to encourage incorporation of the tissue structure into the implant and promote stabilization and healing.

Abstract: A device (100) for supporting a valve annulus is described that includes spaced apart support members (105) and a connecting member (110) extending between and connecting the support members. At least one adjustor (115) is also provided that is engaged with the connecting member and can be actuated to modify a length of the connecting member between two adjacent support members. In addition, each support member may include at least two channels extending through the support members at different heights with respect to an overall thickness of the respective support member. Each channel may receive a portion of the connecting member therethrough, and each support member may further include a passageway between the channels to allow selection of one of the channels. In this way, the device may be adjusted in at least two dimensions to support the valve leaflets and promote sufficient closure of the leaflets.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to attach to one or more portions of a bone. An exemplary bone fixation implant includes a two-dimensional structure comprising a bone-engaging surface and a tissue-engaging surface. A plurality of openings is defined in the two-dimensional structure, and arranged across a length and a width of the bone fixation implant. At least some of openings are configured to receive an attachment member for securing the bone fixation implant to an underlying bone structure. The tissue-engaging surface is configured to engage an overlying tissue structure for encouraging incorporation of the tissue structure into the bone fixation implant to promote stabilization of the underlying bone structure during healing. In certain embodiments, at least 50% of the area defined by and/or between the length and the width of the two-dimensional structure is an opening.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to be attached to one or more portions of bone. The bone fixation implant may include at least one structural portion (e.g., a wire, plate, mesh, etc.) that includes metal and a polymer body at least partially surrounding the at least one structural portion. The polymer body may define an engaging surface that is configured to engage an attachment member that is applied to the bone fixation implant to fix the bone fixation implant to the bone, such that direct contact between the metal of the structural portion and the attachment member is prevented. Overlying muscle and tissue may be secured to the bone fixation implant to encourage incorporation of the tissue structure into the implant and promote stabilization and healing.

Abstract: Devices and methods are described for treating a mitral valve defect. The device described includes features that allow the device to conform to the actual pathology of the valve, rather than attempting to replicate a healthy valve (which the patient does not have). In this way, the device allows the patient's actual value to work as well as possible, given the valve's diseased condition. The actual pathology of the valve is accommodated by providing for multiple dimensions of adjustability of the device, including adjustability of the size (e.g., diameter) of the device as well as adjustability of the elevation or inclination of one portion of the device (e.g., the portion supporting the posterior leaflet) with respect to another portion of the device.