Patents by Inventor Jen-Tsan Chi
Jen-Tsan Chi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11712696Abstract: A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module.Type: GrantFiled: August 5, 2021Date of Patent: August 1, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Te-Yu Chao, Yu-Ching Tung, Mao-Chih Hsieh, Yu-Ting Tai, Bing-Ying Ho, Wei-Chia Chang, Sung-Yang Wei, Chang-Hung Hsieh, Chung-Cheng Chou, Jen-Tsan Chi, Long Hsu, Hwan-You Chang, Huang-Ming Philip Chen, Cheng-Hsien Liu
-
Patent number: 11609185Abstract: A portable ring-type fluorescence optical system for observing microfluidic channel and an operating method thereof are disclosed. The portable ring-type fluorescence optical system includes a photographic chip, a first polarizer, an objective lens, a ring-type fluorescent light source, a biological sample on a microfluidic chip, a second polarizer and a bottom illumination light source arranged in order from top to bottom. The ring-type fluorescent light source is used to generate a ring-type fluorescent light to the biological sample on the microfluidic chip. The objective lens is used to magnify a fluorescent image of the biological sample on the microfluidic chip to focus on the photographic chip. The first polarizer disposed under the photographic chip and the second polarizer disposed under the biological sample form a non-zero angle to each other to block reflected lights that the biological sample reflects the lights emitted by the bottom illumination light source.Type: GrantFiled: August 9, 2021Date of Patent: March 21, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Sung-Yang Wei, Long Hsu, Hwan-You Chang, Huang-Ming Chen, Jen-Tsan Chi, Chung-Cheng Chou, Yuh-Cherng Lai, Hung-Yu Yeh, Ting-Chou Wei, Yun-Ting Yao, Cheng-Hsien Liu
-
Publication number: 20220401956Abstract: A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module.Type: ApplicationFiled: August 5, 2021Publication date: December 22, 2022Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Te-Yu CHAO, Yu-Ching TUNG, Mao-Chih HSIEH, Yu-Ting TAI, Bing-Ying HO, Wei-Chia CHANG, Sung-Yang WEI, Chang-Hung HSIEH, Chung-Cheng CHOU, Jen-Tsan CHI, Long HSU, Hwan-You CHANG, Huang-Ming Philip CHEN, Cheng-Hsien LIU
-
Publication number: 20220364995Abstract: A portable ring-type fluorescence optical system for observing microfluidic channel and an operating method thereof are disclosed. The portable ring-type fluorescence optical system includes a photographic chip, a first polarizer, an objective lens, a ring-type fluorescent light source, a biological sample on a microfluidic chip, a second polarizer and a bottom illumination light source arranged in order from top to bottom. The ring-type fluorescent light source is used to generate a ring-type fluorescent light to the biological sample on the microfluidic chip. The objective lens is used to magnify a fluorescent image of the biological sample on the microfluidic chip to focus on the photographic chip. The first polarizer disposed under the photographic chip and the second polarizer disposed under the biological sample form a non-zero angle to each other to block reflected lights that the biological sample reflects the lights emitted by the bottom illumination light source.Type: ApplicationFiled: August 9, 2021Publication date: November 17, 2022Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Sung-Yang WEI, Long HSU, Hwan-You CHANG, Huang-Ming CHEN, Jen-Tsan CHI, Chung-Cheng CHOU, Yuh-Cherng LAI, Hung-Yu YEH, Ting-Chou WEI, Yun-Ting YAO, Cheng-Hsien LIU
-
Patent number: 11008619Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to antiplatelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.Type: GrantFiled: May 16, 2019Date of Patent: May 18, 2021Assignee: Duke UniversityInventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
-
Publication number: 20200063203Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to antiplatelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.Type: ApplicationFiled: May 16, 2019Publication date: February 27, 2020Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
-
Patent number: 10329618Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.Type: GrantFiled: September 6, 2013Date of Patent: June 25, 2019Assignee: Duke UniversityInventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
-
Publication number: 20160287575Abstract: Provided herein are interfering molecules and pharmaceutical combinations comprising such interfering molecules that modulate the Hippo signaling pathway. Also provided are methods of treating and preventing a disease or condition associated disruption of a Hippo signaling pathway component, such as skeletal muscle disorders and cancers, where the method comprises administering to a subject in need thereof an interfering molecule or pharmaceutical composition described herein.Type: ApplicationFiled: November 14, 2014Publication date: October 6, 2016Applicant: Duke UniversityInventors: Corinne M. Linardic, Lisa E.S. Crose, Jen-Tsan Chi
-
Publication number: 20150322514Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.Type: ApplicationFiled: September 6, 2013Publication date: November 12, 2015Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
-
Publication number: 20090124566Abstract: Methods to determine the susceptibility of a subject to erythrocyte diseases are provided. The methods comprise determining the miRNA compositions of erythrocytes from the subject. The present invention has discovered that erythrocytes comprise microRNA (miRNA) populations and the populations can be profiled or analyzed and used to determine the susceptibility for disease. The miRNA compositions can also be used to determine the severity of erythrocyte disease, and the features and clinical phenotypes of the erythrocyte disorders. Also provided are pharmaceutical compositions comprising erythrocyte miRNAs and methods for the treatment of a subject with an erythrocyte disease. In other embodiments of the invention, the miRNAs can be used to increase the life-span of erythrocytes through the introduction of an erythrocyte miRNA.Type: ApplicationFiled: June 6, 2008Publication date: May 14, 2009Applicant: DUKE UNIVERSITYInventors: Jen-Tsan Chi, Gregory Lamonte, Shao-Yin Chen
-
Publication number: 20050026286Abstract: RNAi arrays and methods for using the same are provided. The subject arrays are characterized by having two or more distinct RNAi agents. The arrays find use in methods where cells are contacted with the arrays and the activity of the RNAi agents is determined by evaluating the contacted cells. The subject arrays and methods find use in a variety of applications, such as high throughput loss of function genomic applications.Type: ApplicationFiled: March 4, 2004Publication date: February 3, 2005Inventors: Jen-Tsan Chi, Howard Chang, Patrick Brown
-
Publication number: 20040248164Abstract: RNAi arrays and methods for using the same are provided. The subject arrays are characterized by having two or more distinct RNAi agents. The arrays find use in methods where cells are contacted with the arrays and the activity of the RNAi agents is determined by evaluating the contacted cells. The subject arrays and methods find use in a variety of applications, such as high throughput loss of function genomic applications.Type: ApplicationFiled: March 4, 2004Publication date: December 9, 2004Inventors: Jen-Tsan Chi, Howard Y. Chang, Patrick Brown