Abstract: A pharmaceutical composition in a form of an orally deliverable liquid comprises water having in solution therein a pharmaceutically acceptable water-soluble salt of a tolterodine related compound at a therapeutically effective concentration in the composition. The composition has a pH of about 2 to about 6 and further comprises a sweetening agent and an antimicrobial agent at a concentration that is antimicrobially effective at the pH of the composition. The composition is useful for treating a muscarinic receptor mediated disorder, more particularly overactive bladder, in a subject by orally administering to the subject a therapeutically effective amount of the composition.

Abstract: The present invention is directed to dry formulations of coated oxazolidinone particles, such as coated linezolid particles, which, when suspended in an aqueous solution, mask the taste of the oxazolidinone in the resulting suspension vehicle. Specifically, a mixture of sugars in the formulation, comprising sorbitol and sucrose, inhibit mass transport of the oxazolidinone from the particles into the suspension vehicle. Dry formulations of the coated oxazolidinone particles, suspensions of the same, and methods of using the same to treat or prevent infections from gram positive bacteria are all disclosed.

Abstract: The present invention is directed to a suspension vehicle for coated drug particles. The coated drug particles are suitable for use in taste masking. The suspension vehicle disclosed enables the maintenance of coated drug particles with an average particle size of about 50 &mgr;m to about 600 &mgr;m in suspension for an extended period of time, without sedimentation or floating, even after shaking in the presence of air. The suspension vehicle of the present invention makes it possible to produce multidose oral suspensions of coated drugs, from which consistent dosages can be dispensed over time. The dry formulations, methods, and suspension vehicles of the present invention are particularly well suited for the delivery of objectionable tasting drugs, such as linezolid.