Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: The invention describes novel 1-aryl-5-(substituted alkyl (thio)amido)pyrazoles wherein preferred compounds are of the formula ##STR1## wherein: R.sup.2 is R.sup.11 S(O).sub.n in which n is 0, 1 or 2 and R.sup.11 is alkyl, preferably methyl; or haloalkyl, preferably trihalomethyl or dihalomethyl; and in which halo is F, Cl or Br or combinations thereof and most preferably CF.sub.3, CCl.sub.3, CF.sub.2 Cl, CFCl.sub.2, CF.sub.2 Br, CHF.sub.2, CHClF or CHCl.sub.2 ;R.sub.4 is H or alkyl;R.sub.5 is H or alkyl;R.sup.4 and R.sup.5 could be together to form a 3-7 membered cyclic ring system;R.sup.6 is alkoxy, alkoxy(alkoxy).sub.b [b=1-2], alkoxy(alkoxy).sub.b alkyl [b=0-2], alkylS(O).sub.c (c=0, 1, 2), alkylS(O).sub.c alkyl [c=0, 1, 2], alkylC(O)--; phenoxy, phenyl S(O).sub.c, phenylalkoxy, pyridyloxy, pyridyl S(O).sub.c, optionally substituted with alkyl, halogen, alkoxy, haloalkyl, haloalkoxy, nitro, cyano, alkylthio.R.sup.5 and R.sup.6 could be together to form a 4-7 membered cyclic ring with 1-2 heteroatoms (e.g.

Abstract: The invention describes novel 1-(2-pyridyl)pyrazoles of formula (I) ##STR1## wherein typically preferred substituents are: X is S(O).sub.n R.sub.1, in which R.sub.1 is an alkyl group, preferably a methyl group, which is fully substituted by halogen atoms, and n is 0, 1 and 2;Y is hydrogen, halogen, cyano, alkylsulfenyl, alkylsulfinyl, alkylsulfonyl, alkoxy, amino, alkylamino, dialkylamino, trialkylammonium salt, cyanoalkylamino, alkoxyalkylamino, alkoxycarbonylamino, alkylcarbonylamino, haloalkylcarbonylamino, alkylaminocarbonylamino, dialkylaminocarbonylamino or alkoxyalkylideneimino, wherein the alkyl and alkoxy moieties are a linear or branched chain, containing one to four carbon atoms, and the halo-substitution consists of one or more halogen atoms, which are the same or different, up to full substitution of the alkyl moiety;Z is cyano; andR.sub.2, R.sub.3, R.sub.4, and R.sub.