Patents by Inventor Jennifer L. West
Jennifer L. West has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240083982Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.Type: ApplicationFiled: July 21, 2023Publication date: March 14, 2024Inventors: Barry D. Olafson, Stephen L. Mayo, Pamela J. Bjorkman, Jost G. Vielmetter, Justin W. Chartron, Paul M. Chang, Stephanie C. Contreras, Jingzhou Wang, Aiden J. Aceves, Anthony P. West, Jr., Christopher O. Barnes, Jennifer R. Keeffe, Claudia A. Jette
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Patent number: 9981010Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.Type: GrantFiled: January 12, 2015Date of Patent: May 29, 2018Assignees: Baylor College of Medicine, William Marsh Rice UniversityInventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke M. Olabisi, Jennifer L. West, Christy Franco
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Patent number: 9452239Abstract: Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.Type: GrantFiled: August 17, 2011Date of Patent: September 27, 2016Assignees: William Marsh Rice University, University of PennsylvaniaInventors: Jennifer L. West, Christopher S. Chen, Jordan S. Miller, Michael T. Yang
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Publication number: 20150359852Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.Type: ApplicationFiled: January 12, 2015Publication date: December 17, 2015Applicants: WILLIAM MARSH RICE UNIVERSITY, BAYLOR COLLEGE OF MEDICINEInventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke M. Olabisi, Jennifer L. West, Christy Franco
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Patent number: 8961999Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.Type: GrantFiled: December 1, 2010Date of Patent: February 24, 2015Assignees: Baylor College of Medicine, William Marsh Rice UniversityInventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke Olabisi, Jennifer L. West, Christy Franco
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Patent number: 8791073Abstract: Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane comprising: providing an isocyanate; providing a chain extender; providing a peptide; and allowing the isocyanate, chain extender, and peptide to react thereby forming the peptide-modified polyurethane, as well as methods for treating a subject comprising: providing a peptide-modified polyurethane that comprises the reaction product of an isocyanate, a chain extender, and a peptide; and administering the peptide-modified polyurethane to the subject.Type: GrantFiled: May 16, 2005Date of Patent: July 29, 2014Assignee: William Marsh Rice UniversityInventors: Jennifer L. West, Ho-Wook Jun, Lakeshia J. Taite
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Publication number: 20130017228Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.Type: ApplicationFiled: December 1, 2010Publication date: January 17, 2013Applicant: Baylor College of MedicineInventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke Olabisi, Jennifer L. West, Christy Franco
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Publication number: 20120058174Abstract: Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.Type: ApplicationFiled: August 17, 2011Publication date: March 8, 2012Inventors: Jennifer L. West, Christopher S. Chen, Jordan S. Miller, Michael T. Yang
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Patent number: 7651697Abstract: Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed.Type: GrantFiled: November 17, 2005Date of Patent: January 26, 2010Assignee: Rice UniversityInventors: Jennifer L. West, Kristyn Simcha Masters
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Patent number: 7635592Abstract: Matrix-enhancing molecules, such as TGF-?, are conjugated to or immobilized on scaffolds to increase ECM production by cells for tissue engineering, tissue regeneration and wound healing applications. The matrix-enhancing molecule is conjugated to a tether, such as polyethylene glycol (PEG) monoacrylate, for attachment to a tissue engineering or cell growth scaffold. The matrix-enhancing molecule retains activity after attachment to the scaffold, and causes cells growing in or on the scaffold to increase extracellular matrix (ECM) production, without substantially increasing proliferation of the cells, even when the scaffold additionally contains cell adhesion ligands. The increased ECM produced by the cells aids in maintaining the integrity of the scaffold, particularly when the scaffold is degradable, either by hydrolysis or by enzymatic degradation.Type: GrantFiled: August 21, 2001Date of Patent: December 22, 2009Assignee: Rice UniversityInventors: Jennifer L. West, Brenda K. Mann
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Publication number: 20080241071Abstract: Novel nanoparticulate compositions of luminescent probes, as well as methods of using such compositions and systems comprising such compositions are provided. One such composition comprises at least one probe comprising a quantum dot, at least one metal nanoparticle, and at least one tether that is attached to the quantum dot and to the at least one metal nanoparticle. One such method comprises providing at least one such probe, introducing the at least one probe into a subject; and detecting luminescence from the at least one probe in the subject. One such system comprises at least one such probe and a detector capable of detecting luminescence from the quantum dot, wherein the detector is positioned in relation to the at least one probe such that luminescence can be detected.Type: ApplicationFiled: January 11, 2008Publication date: October 2, 2008Inventors: Jennifer L. West, Rebekah A. Drezek
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Patent number: 7279176Abstract: Hydrogels releasing or producing NO, most preferably photopolymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The hydrogels are typically formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material.Type: GrantFiled: September 1, 2000Date of Patent: October 9, 2007Assignee: Rice UniversityInventors: Jennifer L. West, Kristyn Simcha Bohl
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Patent number: 7052711Abstract: Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed.Type: GrantFiled: September 4, 2001Date of Patent: May 30, 2006Assignee: Rice UniversityInventors: Jennifer L. West, Kristyn Simcha Masters
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Patent number: 6699724Abstract: The present invention provides nanoshell particles (“nanoshells”) for use in biosensing applications, along with their manner of making and methods of using the nanoshells for in vitro and in vivo detection of chemical and biological analytes, preferably by surface enhanced Raman light scattering. The preferred particles have a non-conducting core and a metal shell surrounding the core. For given core and shell materials, the ratio of the thickness (i.e., radius) of the core to the thickness of the metal shell is determinative of the wavelength of maximum absorbance of the particle. By controlling the relative core and shell thicknesses, biosensing metal nanoshells are fabricated which absorb light at any desired wavelength across the ultraviolet to infrared range of the electromagnetic spectrum. The surface of the particles are capable of inducing an enhanced SERS signal that is characteristic of an analyte of interest.Type: GrantFiled: July 14, 2000Date of Patent: March 2, 2004Assignee: Wm. Marsh Rice UniversityInventors: Jennifer L. West, Nancy J. Halas, Steven J. Oldenburg, Richard D. Averitt
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Patent number: 6685730Abstract: This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.Type: GrantFiled: September 25, 2002Date of Patent: February 3, 2004Assignee: Rice UniversityInventors: Jennifer L. West, Rebekah Drezek, Scott Sershen, Nancy J. Halas
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Patent number: 6645517Abstract: A thermally sensitive polymer-particle composite that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical is disclosed. Metal nanoshells are nanoparticulate materials that are suitable for use in the present composites and can be made according to a process that includes optically tuning or tailoring their maximum optical absorption to any desired wavelength primarily by altering the ratio of the core diameter to the shell thickness. Preferred nanoshells are selected that strongly absorb light in the near-infrared and thus produce heat. These nanoshells are combined with a temperature-sensitive material to provide an implantable or injectable material for modulated drug delivery via external exposure to near-IR light. This invention provides a means to improve the quality of life for persons requiring multiple injections of a drug, such as diabetes mellitus patients.Type: GrantFiled: June 5, 2002Date of Patent: November 11, 2003Assignee: William Rice Marsh Rice UniversityInventors: Jennifer L. West, Scott R. Sershen, Nancy J. Halas, Steven J. Oldenburg, Richard D. Averitt
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Publication number: 20030118657Abstract: Disclosed is a method for reducing excessive or inappropriate neovasculature, including nevasculature in the eye which interferes with or has potential to interfere with vision, for example, that associated with diabetic retinopathy or macular degeneration. The regions of the neovasculature are targeted with nanoparticles, including metal nanoshells, which are then irradiated, preferably with a laser, to heat them and ablate the undesired blood vessels. The nanoparticles are targeted to the neovasculature by linking them with a targeting agent, including, for example, antibodies, antibody fragments, receptor binding proteins or other proteins or molecules including growth factors.Type: ApplicationFiled: December 3, 2002Publication date: June 26, 2003Inventors: Jennifer L. West, J. Donald Payne
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Publication number: 20030093092Abstract: This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.Type: ApplicationFiled: September 25, 2002Publication date: May 15, 2003Inventors: Jennifer L. West, Rebekah Drezek, Scott Sershen, Nancy J. Halas
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Patent number: 6530944Abstract: This invention is generally in the field of improved methods for the localized delivery of heat and the localized imaging of biological materials. The delivery may be in vitro or in vivo and is useful for the localized treatment of cancer, inflammation or other disorders involving overproliferation of tissue. The method is also useful for diagnostic imaging. The method involves localized induction of hyperthermia in a cell or tissue by delivering nanoparticles to said cell or tissue and exposing the nanoparticles to an excitation source under conditions wherein they emit heat.Type: GrantFiled: February 8, 2001Date of Patent: March 11, 2003Assignee: Rice UniversityInventors: Jennifer L. West, Nancy J. Halas, Leon R. Hirsch
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Publication number: 20030012816Abstract: Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed.Type: ApplicationFiled: May 17, 2002Publication date: January 16, 2003Inventors: Jennifer L West, Kristyn Simcha Masters