Abstract: In one aspect provided herein are methods of determining a triple negative breast cancer (TNBC) subtype in an individual in need thereof comprising determining expression of one or more genes in one or more TNBC cells of the individual; and comparing the expression of the one or more genes in the TNBC cells with the expression of the one or more genes in a control. In another aspect, the methods are directed to determining a treatment protocol for the TNBC patient based on the TNBC subtype. In another aspect, the methods are directed to predicting whether an individual will benefit from a treatment for a particular TNBC subtype. In yet another aspect, the invention is directed to a method of determining whether an agent can be used to treat a TNBC subtype.

Abstract: A system for teaching learners to write letters of an alphabet uses a plurality of template blocks, each having a cutout corresponding to a letter of the alphabet. A bottom wall of the cutout is covered with all abrasive material to facilitate tactile recognition of the letter shape by the learner. The kit has a plurality of insert members that make letter-forming components, such that one or more insert members fitted in the cutout form the corresponding letter of the alphabet.

Abstract: A system for teaching learners to write letters of an alphabet uses a plurality of template blocks, each having a cutout corresponding to a letter of the alphabet. A bottom wall of the cutout is covered with an abrasive material to facilitate tactile recognition of the letter shape by the learner. The kit has a plurality of insert members that make letter-forming components, such that one or more insert members fitted in the cutout form the corresponding letter of the alphabet.

Abstract: A system for teaching learners to write letters of an alphabet uses a plurality of template blocks, each having a cutout corresponding to a letter of the alphabet. A bottom wall of the cutout is covered with an abrasive material to facilitate tactile recognition of the letter shape by the learner. The kit has a plurality of insert members that make letter-forming components, such that one or more insert members fitted in the cutout form the corresponding letter of the alphabet.