Patents by Inventor Jennifer Mitcham

Jennifer Mitcham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity
    Patent number: 9051362
    Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: June 9, 2015
    Assignees: Theraclone Sciences, Inc., International AIDS Vaccine Initiative, The Scripps Research Institute
    Inventors: Po-Ying Chan-Hui, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
  • HUMAN M2E PEPTIDE IMMUNOGENS
    Publication number: 20150125423
    Abstract: The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Inventors: Jennifer Mitcham, Matthew Moyle
  • Compositions and Methods for the Therapy and Diagnosis of Influenza
    Publication number: 20150104459
    Abstract: The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 16, 2015
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
    Publication number: 20150098948
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 9, 2015
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8974788
    Abstract: The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: March 10, 2015
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Human M2e peptide immunogens
    Patent number: 8932597
    Abstract: The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: January 13, 2015
    Assignee: Theraclone Sciences, Inc.
    Inventors: Matthew Moyle, Jennifer Mitcham
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8916160
    Abstract: The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 23, 2014
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA
    Publication number: 20140363441
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: April 18, 2014
    Publication date: December 11, 2014
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8858948
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: October 14, 2014
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • HUMAN IMMUNODEFICIENCY VIRUS (HIV)-NEUTRALIZING ANTIBODIES
    Publication number: 20140205612
    Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 24, 2014
    Applicants: THERACLONE SCIENCES, INC., INTERNATIONAL AIDS VACCINE INITIATIVE, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
  • Compositions and Methods for the Therapy and Diagnosis of Influenza
    Publication number: 20140135480
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: June 10, 2013
    Publication date: May 15, 2014
    Applicant: THERACLONE SCIENCES, INC.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8460671
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: June 11, 2013
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres Grandea, III, Gordon King, Thomas Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle
  • Compositions and Methods for the Therapy and Diagnosis of Influenza
    Publication number: 20120315277
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: March 13, 2012
    Publication date: December 13, 2012
    Applicant: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Human M2e peptide immunogens
    Patent number: 8329188
    Abstract: The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: December 11, 2012
    Assignee: Theraclone Sciences, Inc.
    Inventors: Matthew Moyle, Jennifer Mitcham
  • Human M2e Peptide Immunogens
    Publication number: 20120258077
    Abstract: The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 11, 2012
    Applicant: Theraclone Sciences, Inc.
    Inventors: Matthew Moyle, Jennifer Mitcham
  • Compositions and Methods for the Therapy and Diagnosis of Influenza
    Publication number: 20120207760
    Abstract: The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 16, 2012
    Applicant: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas C. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
    Publication number: 20120171218
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: August 23, 2011
    Publication date: July 5, 2012
    Applicant: Theraclone Sciences, Inc.
    Inventors: Andres Grandea, III, Gordon King, Thomas Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
    Publication number: 20120121603
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Application
    Filed: May 20, 2010
    Publication date: May 17, 2012
    Applicant: Theraclone Sciences, Inc.
    Inventors: Andres G. Grandea, III, Gordon King, Thomas c. Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Phil Hammond
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8114402
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: February 14, 2012
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres Grandea, III, Gordon King, Thomas Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle
  • Compositions and methods for the therapy and diagnosis of influenza
    Patent number: 8057796
    Abstract: The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: November 15, 2011
    Assignee: Theraclone Sciences, Inc.
    Inventors: Andres Grandea, III, Gordon King, Thomas Cox, Ole Olsen, Jennifer Mitcham, Matthew Moyle