Abstract: The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

Abstract: The present disclosure relates to methods for determining the presence of or the amount of an analyte in a sample and to a slide for use in the method.

Abstract: Examples of wearable systems and methods can use multiple inputs (e.g., gesture, head pose, eye gaze, voice, and/or environmental factors (e.g., location)) to determine a command that should be executed and objects in the three-dimensional (3D) environment that should be operated on. The multiple inputs can also be used by the wearable system to permit a user to interact with text, such as, e.g., composing, selecting, or editing text.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Described are effervescent dissolvable solid structures comprising effervescent agglomerated particles which enhance the consumer experience and can improve dissolution of the structure. Also described are processes for the Dissolvable Solid Structure comprising effervescent agglomerated particles. Also described are methods for making the effervescent agglomerated particle.

Abstract: Evaluating computers, devices, or endpoints on a network, such as a large network of computers in an enterprise environment. Detecting computers, devices, or endpoints that may present a security risk to the network or may be compromised in some way. Generating network traffic that, in some cases, should be ignored or should prompt specific, known responses. Detecting endpoint(s) that respond to such network traffic in an anomalous way, or otherwise attempt to perform certain operations based on such network traffic.

Abstract: Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a method includes receiving a plurality of additively manufactured objects on a rotor, the plurality of additively manufactured objects having excess material thereon. The method can include removing the excess material from the plurality of additively manufactured objects by rotating the plurality of additively manufactured objects via the rotor. The method can further include applying energy to the plurality of additively manufactured objects to cure a portion of each additively manufactured object while the plurality of additively manufactured objects are on the rotor.

Abstract: The present invention relates to quinazolinones and related compounds which degrade PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.

Abstract: A method including detecting that a vehicle that may be propelled by an electric drive system having one or more motors disconnects or begins disconnecting from an off-board source of power while the one or more motors are being powered by the off-board source of power. The method may include supplanting a decreasing amount of a first electric energy supplied by the off-board source of power to the electric drive system with an amount of a second electric energy supplied by an onboard source of power to the electric drive system responsive to the detection of the disconnect from the off-board source of power.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The present disclosure relates to techniques for abstraction of unstructured clinical trial health data. Particularly, aspects are directed to obtaining, by a data transformation system, an unstructured document that includes various types of content for a given event. The data transformation system converts the unstructured document from an original format into a standardized format. The data transformation system processes the unstructured document in the standardized format to identify template-mapped content data and processes the template-mapped content data to identify high-interest content data. The data transformation system generates a dictionary data structure comprising key-value pairs for each of the template-mapped content data and the high-interest content data. The data transformation system generates a structured document based on the dictionary data structure for each of the template-mapped content data and the high-interest content data.

Abstract: The disclosed upper body garments are designed to address the need for knit shapewear that stays in place, is not visible through outerwear, and is still able to provide excellent shaping. Particularly, the upper body garments disclosed herein include left and right side inserts that extend upward from the lower edge of the garment. The side inserts help the lower portion of the garment to adapt to the individual shape of the wearer. In some embodiments, the left and right side inserts are not visible on the exterior surface of the garment. Methods of making the upper body garments including the side inserts are also disclosed herein.

Abstract: A method of site specific labelling of an interferon molecule is provided. The method comprises the steps: a) providing a label molecule comprising a PEG moiety having an aldehyde or ketone moiety; b) providing an interferon molecule having a C terminal hydrazide moiety; and c) allowing the aldehyde or ketone moiety of the PEG moiety to react with the C terminal hydrazide of the interferon molecule to form a labelled interferon molecule, which comprises a PEG moiety attached to the C terminus of the interferon molecule via a hydrazone bond. Interferon molecules labelled using such a method are also described.

Abstract: A stretchable fabric sleeve is configured for use as a prosthetic shrinker or as a prosthetic sock and broadly comprises a unitary receptacle broadly including a tubular section and a rounded end section. In particular, the rounded end section includes opposite panels that are knitted in seriatim with a plurality of interlaced short rows that provide a progressive taper from the open margin of the tubular section to the lowermost toe end of the end section. The progressive taper of the knitted panels permits the outermost edge of the rounded end section to assume a rounded shape that comfortably conforms to an amputated limb and is devoid of any sewn seams that would otherwise irritate the sensitive end of the amputated limb.

Abstract: A stretchable fabric sleeve is configured for use as a prosthetic shrinker or as a prosthetic sock and broadly comprises a unitary receptacle broadly including a tubular section and a rounded end section. In particular, the rounded end section includes opposite panels that are knitted in seriatim with a plurality of interlaced short rows that provide a progressive taper from the open margin of the tubular section to the lowermost toe end of the end section. The progressive taper of the knitted panels permits the outermost edge of the rounded end section to assume a rounded shape that comfortably conforms to an amputated limb and is devoid of any sewn seams that would otherwise irritate the sensitive end of the amputated limb.

Abstract: Cooperative touch fasteners have a sheet-form base with an upper face and a lower face. Extending outwardly from, and integral with the upper face of the base is a plurality of fastener elements. Additionally, the lower face of the sheet-form base has a pressure adhesive property and is coated with a cross-linkable adhesive. The cooperative touch fasteners can be used to alter garments, hang window coverings and attach finishing covers. Additionally, the fasteners can be used in place of snaps and buttons, in medical devices, with diapers and in conjunction with a variety of manufacturing techniques.

Abstract: Cooperative touch fasteners are described herein. The fasteners have a sheet-form base portion with an upper face and a lower face. Extending outwardly from, and integral with the upper face of the base portion is a plurality of fastener elements. Additionally, the lower face of the sheet-form base has a pressure adhesive property and is coated with a cross-linkable adhesive. The cooperative touch fasteners can be used to alter garments, hang window coverings and attach finishing covers. Additionally, the fasteners can be used in place of snaps and buttons, in medical devices, with diapers and in conjunction with a variety of manufacturing techniques.