Patents by Inventor Jens Bukh

Jens Bukh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloned genome of infectious hepatitis C virus strain HC-TN and uses thereof
    Patent number: 7678569
    Abstract: Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: March 16, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Robert H. Purcell, Suzanne U. Emerson, Akito Sakai
  • Hepatitis C Virus Neutralizing Antibodies
    Publication number: 20090311248
    Abstract: The invention relates to anti-HCV antibodies and more specifically to neutralizing anti-HCV antibodies and their variable and complementarity determining regions (CDR). In particular, the neutralizing anti-HCV antibodies are neutralizing anti-HCV envelope protein 1 (HCV E1) antibodies. Also subject of the invention are compositions comprising these antibodies, CDRs or variable regions, and compounds comprising at least one of the CDRs or variable regions of said antibodies. Further subject of the invention are the application of any of said antibodies, CDRs, variable regions or compounds in HCV prophylaxis, therapy, and diagnosis, as well as methods for producing the antibodies.
    Type: Application
    Filed: March 22, 2007
    Publication date: December 17, 2009
    Inventors: Erik Depla, Robert Purcell, Jens Bukh, Suzanne Emerson, Jean-Christophe Meunier
  • CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF
    Publication number: 20090252755
    Abstract: Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
    Type: Application
    Filed: April 2, 2008
    Publication date: October 8, 2009
    Inventors: Jens Bukh, Robert H. Purcell, Suzanne U. Emerson, Akito Sakai
  • Hepatitis C Virus Neutralizing Antibodies
    Publication number: 20090104207
    Abstract: The invention relates to anti-HCV antibodies and more specifically to neutralizing anti-HCV antibodies and their variable and complementarity determining regions (CDR). In particular, the neutralizing anti-HCV antibodies are neutralizing anti-HCV envelope protein 1 (HCV E1) antibodies. Also subject of the invention are compositions comprising these antibodies, CDRs or variable regions, and compounds comprising at least one of the CDRs or variable regions of said antibodies. Further subject of the invention are the application of any of said antibodies, CDRs, variable regions or compounds in HCV prophylaxis, therapy, and diagnosis, as well as methods for producing the antibodies.
    Type: Application
    Filed: March 22, 2007
    Publication date: April 23, 2009
    Inventors: Erik Depla, Robert Purcell, Jens Bukh, Suzanne Emerson, Jens-Christophe Meunier
  • Cloned genomes of infectious hepatitis C viruses and uses thereof
    Publication number: 20080014212
    Abstract: The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
    Type: Application
    Filed: April 9, 2007
    Publication date: January 17, 2008
    Inventors: Masayuki Yanagi, Jens Bukh, Suzanne Emerson, Robert Purcell
  • Cloned genome of infectious hepatitis C virus of genotype 2A and uses thereof
    Publication number: 20070141668
    Abstract: The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
    Type: Application
    Filed: June 12, 2006
    Publication date: June 21, 2007
    Inventors: Masayuki Yanagi, Jens Bukh, Suzanne Emerson, Robert Purcell
  • Cloned genomes of infectious hepatitis C viruses and uses thereof
    Patent number: 7201911
    Abstract: The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 10, 2007
    Assignee: United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Masayuki Yanagi, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
  • Infectious cDNA clone of GB virus B and uses thereof
    Patent number: 7129342
    Abstract: The present invention relates to nucleic acid sequence which comprises the genome of an infectious GB virus B clone. The invention also relates to the use of the nucleic acid sequence of the infectious GB virus B clone to indirectly study the molecular properties of HCV, and in the production of HCV/GBV-B chimeras. The invention further relates to the use of the infectious nucleic acid sequence of GB virus B clone and the HCV/GBV-B chimeras in the development of vaccines and therapeutics for HCV.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: October 31, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Masayuki Yanagi, Suzanne U. Emerson, Robert H. Purcell
  • Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof
    Patent number: 7084266
    Abstract: The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, gentotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
    Type: Grant
    Filed: February 6, 2000
    Date of Patent: August 1, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Masayuki Yanagi, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
    Patent number: 7070790
    Abstract: The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope 1 and core proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: July 4, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • HCV/BVDV chimeric genomes and uses thereof
    Patent number: 7009044
    Abstract: The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
    Type: Grant
    Filed: February 6, 2000
    Date of Patent: March 7, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jae-Hwan Nam, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
    Patent number: 6572864
    Abstract: The nucleotide and deduced amino acid sequences of 51 cDNAs are disclosed where each cDNA encodes the envelope 1 gene of an isolate of hepatitis C virus (HCV). The invention relates to the oligonucleotides, peptides and recombinant envelope 1 proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • Cloned genomes of infectious hepatitis C viruses and uses thereof
    Patent number: 6153421
    Abstract: The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: November 28, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Masayuki Yanagi, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines
    Patent number: 6110465
    Abstract: The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 29, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
    Patent number: 5882852
    Abstract: The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope 1 and core proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: March 16, 1999
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods
    Patent number: 5871962
    Abstract: The nucleotide and deduced amino acid sequences of 51 cDNAs are disclosed where each cDNA encodes the envelope 1 gene of an isolate of hepatitis C virus (HCV). The invention relates to the oligonucleotides, peptides and recombinant envelope 1 proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 16, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
    Patent number: 5514539
    Abstract: The nucleotide and deduced amino acid sequences of 51 cDNAs are disclosed where each cDNA encodes the envelope 1 gene of an isolate of hepatitis C virus (HCV). The invention relates to the oligonucleotides, peptides and recombinant envelope 1 proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: May 7, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell