Abstract: The present invention relates to anti-brain target agents and therapeutic uses thereof.

Abstract: Herein is reported a method for the determination of the simultaneous binding of a bispecific antibody to a first and a second antigen comprising the steps of a) incubating a cell expressing cell-membrane bound FRET-donor-tagged first antigen and FRET-acceptor-tagged second antigen with the bispecific antibody, and b) determining the simultaneous binding of the bispecific antibody by determining the energy transfer from the FRET-donor to the FRET-acceptor.

Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: The invention provides anti-TPBG antibodies and methods of using the same.

Abstract: The present invention relates to a process for producing a workpiece made of glass ceramics, and to the workpiece obtainable by the process according to the invention. Further, the invention relates to the use of the workpiece obtained as a dental restoration, and to a process allowing the translucency of a workpiece to be controlled.

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: The invention relates to a vehicle headlight having at least one light source arrangement comprising a laser, and having a headlight lens comprising a body composed of a transparent material, wherein the body comprises at least one light tunnel and a light-conducting part having at least one optically active light exit surface, wherein the light tunnel comprises at least one, more particularly optically active, light entrance surface and undergoes transition with a bend into the light-conducting part for the purpose of imaging the bend as a bright-dark boundary by means of light coupled or radiated from the light source arrangement into the light entrance surface.

Abstract: A method for animating a map resource is provided, the method includes receiving a plurality of Uniform Resource Locators (URLs) from a third party website, the plurality of URLs comprising one or more attributes; receiving a user selection to create an animation sequence of one or more of the attributes; querying a current value of the one or more attributes from an external resource and returning the queried value; receiving, from the user, a first keyframe and a second keyframe for the animation sequence; interpolating one or more additional keyframes with assigned values; and creating the animation sequence based on the first keyframe, the second keyframe, and the one or more additional keyframes.

Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.

Abstract: The present invention relates to Bispecific antibodies against human TWEAK and human IL17 (bispecific TWEAK-IL17 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: A submarine is designed for combating oil when submerged. The submarine includes a snout (14, 36) which is conduit-connected to a conduit leading into the submarine. The snout (14, 36) is part of an oil suction device and/or part of a device for bringing out an oil decomposition substance. The snout (14) may be designed in a rigid manner and be pivotable from a position between a pressure hull (6) of the submarine and an outer hull (10) forming an upper deck (12) of the submarine, into a position outside the outer hull (10). The snout (36) may also be designed in a flexible manner, wherein the snout (36) is fastened in a section adjacent to a free end, on an ROV (40).

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: Bispecific tetravalent antibodies against IL-17 and TNFa, useful in therapy, e.g. the treatment of rheumatoid arthritis and other autoimmune diseases and/or to reduce pathological inflammatory conditions.

Abstract: A method for animating a map resource is provided, the method includes receiving a plurality of Uniform Resource Locators (URLs) from a third party website, the plurality of URLs comprising one or more attributes; receiving a user selection to create an animation sequence of one or more of the attributes; querying a current value of the one or more attributes from an external resource and returning the queried value; receiving, from the user, a first keyframe and a second keyframe for the animation sequence; interpolating one or more additional keyframes with assigned values; and creating the animation sequence based on the first keyframe, the second keyframe, and the one or more additional keyframes.

Abstract: An implant 1 comprising an enossal area 3 and provided with a coating 2, wherein the coating 2 at least partially covers the enossal area 3, and the coating 2 facilitates the ongrowth of the implant 1 within the bone, characterized in that said coating can be removed chemically and/or mechanically under physiological condition.

Abstract: A resonator (1) has at least first and second annular chambers (2, 3, 17) arranged between inlet and outlet pieces (22, 21). An inner pipe (4) extends between the inlet piece (22) and the outlet piece (21) and has wall holes (23) that connect to the annular chambers (2, 3, 17). The first annular chamber (2) has a U-shaped circumferential wall (6) coaxial to the resonator longitudinal axis (5) and transitions at both ends to engage the inner pipe (4). The second annular chamber (3) has an L-shaped circumferential wall (12) coaxial to the resonator longitudinal axis (5). An end of the L-shaped circumferential wall remote from the first annular chamber (2) transitions into a cylindrical end piece (13), and an opposite end of the L-shaped circumferential wall lies on part of the outer wall (9) of the first annular chamber (2) extending parallel to the resonator longitudinal axis (5).

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.