Patents by Inventor Jens Houghton-Larsen

Jens Houghton-Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Production of Steviol Glycosides
    Publication number: 20240110215
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: September 20, 2023
    Publication date: April 4, 2024
    Inventors: Ganesh M. Kishore, Michael Motion, Paula M. Hicks, Jorgen Hansen, Jens Houghton Larsen, Esben Halkjaer Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
  • Recombinant Production of Steviol Glycosides
    Publication number: 20230407360
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: April 7, 2023
    Publication date: December 21, 2023
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen-Halkjaer, Ernesto Simon, Sabina Tavares
  • GENETICALLY MODIFIED HOST CELLS PRODUCING BENZYLISOQUINOLINE ALKALOIDS
    Publication number: 20230332195
    Abstract: The invention relate to genetically modified hosts cell comprising a pathway having enhanced production of one or more benzylisoquinoline alkaloids wherein the cell expresses heterologous insect genes encoding insect demethylases converting thebaine into northebaine, thebaine into oripavine, thebaine into nororipavine and/or oripavine into nororipavine.
    Type: Application
    Filed: October 9, 2020
    Publication date: October 19, 2023
    Applicant: RIVER STONE BIOTECH APS
    Inventors: Angela De CARVALHO, Swee Chuang Lim HALLWYL, Esben Halkjaer HANSEN, Jens HOUGHTON-LARSEN
  • Production of Steviol Glycosides in Recombinant Hosts
    Publication number: 20230212630
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Application
    Filed: August 30, 2022
    Publication date: July 6, 2023
    Inventors: Helene Lunde Robertson, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen
  • Norcoclaurine Synthases With Increased Activity
    Publication number: 20230193333
    Abstract: The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ ID NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.
    Type: Application
    Filed: June 18, 2018
    Publication date: June 22, 2023
    Inventors: Markus Schwab, Franziska Grassinger, Laura Occhipinti, Philipp Friedrich Berninger, Jon Richard Heal, Joseph Michael Sheridan, Anaelle Hatsch, Jens Houghton-Larsen
  • Production of steviol glycosides in recombinant hosts
    Patent number: 11466302
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 11, 2022
    Assignee: EVOLVA SA
    Inventors: Helene Lunde Robertsen, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen
  • Recombinant Production of Steviol Glycosides
    Publication number: 20220228185
    Abstract: Recombiant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorgansims, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: September 10, 2021
    Publication date: July 21, 2022
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS
    Publication number: 20220195477
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 23, 2022
    Inventors: Jane Dannow Dykejar, Jens HOUGHTON-LARSEN, Veronique Douchin
  • PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS
    Publication number: 20220154234
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosides of steviol precursors, and steviol glycoside precursors.
    Type: Application
    Filed: November 3, 2021
    Publication date: May 19, 2022
    Inventors: Iver Klavs Riishede Hansen, Veronique Douchin, Jens Houghton-Larsen, Esben Halkjaer Hansen, Angelika Semmler, Laura Occhipinti, Kim Olsson
  • RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF L-DOPA, DOPAMINE, S-NOROCLAURINE OR DERIVATIVES THEREOF
    Publication number: 20220112528
    Abstract: The present invention relates to a recombinant microbial host cell comprising an operative biosynthetic metabolic pathway capable of producing one or more compounds selected from the group consisting of L-dopa, dopamine, (S)-Norcoclaurine and derivatives thereof; said pathway comprising a heterologous L-tyrosine hydroxylase (TyrH) converting L-Tyrosine into L-dopa capable of increasing the cell production of the Compound compared to a reference L-tyrosine hydroxylase having the sequence set forth in SEQ ID NO: 58.
    Type: Application
    Filed: January 10, 2020
    Publication date: April 14, 2022
    Inventors: Esben Halkjaer HANSEN, Jens HOUGHTON-LARSEN
  • Production of mogroside compounds in recombinant hosts
    Patent number: 11248248
    Abstract: The invention relates to recombinant microorganisms and methods for producing mogroside compounds and mogroside precursors.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: February 15, 2022
    Assignee: EVOLVA SA
    Inventor: Jens Houghton-Larsen
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 11091787
    Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: August 17, 2021
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Katarzyna Krzystanek, Angelika Semmler, Iver Klavs Riishede Hansen, Soren Damkiaer, Yaoquan Liu, Jorgen Hansen, Sathish Kumar, Muthuswamy Panchapagesa Murali, Nina Nicoline Rasmussen
  • Production of Steviol Glycosides in Recombinant Hosts
    Publication number: 20200392552
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Application
    Filed: February 26, 2020
    Publication date: December 17, 2020
    Inventors: Helene Lunde Robertsen, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen
  • METHODS AND MATERIALS FOR BIOSYNTHESIS OF MOGROSIDE COMPOUNDS
    Publication number: 20200325517
    Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
    Type: Application
    Filed: March 2, 2020
    Publication date: October 15, 2020
    Inventors: Jens Houghton-Larsen, Katarzyna Krzystanek, Angelika Semmler, Iver Klavs Riishede Hansen, Soren Damkiaer, Yaoquan Liu, Jorgen Hansen, Sathish Kumar, Muthuswamy Panchapagesa Murali, Nina Nicoline Rasmussen
  • Production of Mogroside Compounds in Recombinant Hosts
    Publication number: 20200165652
    Abstract: The invention relates to recombinant microorganisms and methods for producing mogroside compounds and mogroside precursors.
    Type: Application
    Filed: June 15, 2018
    Publication date: May 28, 2020
    Inventor: Jens Houghton-Larsen
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 10662458
    Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 26, 2020
    Assignee: EVOLVA SA
    Inventors: Yaoquan Liu, Jorgen Hansen, Jens Houghton-Larsen, Muthuswamy Panchapagesa Murali, Sathish Kumar, Nina Nicoline Rasmussen
  • Production of Steviol Glycosides in Microorganisms
    Publication number: 20200140912
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: July 2, 2019
    Publication date: May 7, 2020
    Inventors: Ganesh M. Kishore, Michael Motion, Paula M. Hicks, Jorgen Hansen, Jens Houghton-Larsen, Esben Halkjaer Hansen, Michael Dalgaard Mikkelsen, Sabina Tavares, Charlotte Blom
  • Methods and materials for biosynthesis of mogroside compounds
    Patent number: 10633685
    Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 28, 2020
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Katarzyna Krzystanek, Angelika Semmler, Iver Klavs Riishede Hansen, Soren Damkiaer, Yaoquan Liu, Jorgen Hansen, Sathish Kumar, Muthuswamy Panchapagesa Murali, Nina Nicoline Rasmussen
  • Recombinant Production of Steviol Glycosides
    Publication number: 20200123583
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2019
    Publication date: April 23, 2020
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina Tavares
  • Production of steviol glycosides in recombinant hosts
    Patent number: 10612064
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 7, 2020
    Assignee: Evolva SA
    Inventors: Helene Lunde Robertson, Iben Nordmark Andersen, Adam Matthew Takos, Swee Chuang Lim Hallwyl, Francesca Ambri, Manuel Quiros Asensio, Michael Dalgaard Mikkelsen, Jens Houghton-Larsen, Veronique Douchin, Jane Dannow Dyekjaer, Simon Carlsen, Nina Nicoline Rasmussen, Esben Halkjaer Hansen