Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving a radiotherapy optimization problem, the radiotherapy problem comprising a plurality of parameters; processing the radiotherapy optimization problem to instantiate a first set of candidate parameters; converting the first set of candidate parameters into an adapted representation; defining an adapted radiotherapy optimization problem as a function of the adapted representation such that a given solution to the adapted optimization problem estimates a solution to the radiotherapy optimization problem; processing the adapted radiotherapy optimization problem to estimate a function of the solution to the adapted radiotherapy optimization problem; and processing the estimated function of the solution to the adapted optimization problem to generate a deliverable radiotherapy treatment plan.

Abstract: Techniques for producing segmentation with privacy are provided.

Abstract: The present invention relates to the field of radiation therapy and methods, software and systems for adaptive radiotherapy. There is provided a method for adaptive radiotherapy treatment of a patient comprising receiving a sequence of measurement data of the treatment, the measurements being captured at different time points, mapping measurement data to a representation of a treatment geometry at the time points, using the representation in a dynamical model describing how variables in the representation evolve over time, based on the dynamical model, estimating positions over time of the treatment geometry or selected parts of the treatment geometry, determining a treatment action for the patient at a defined time point using the estimation from the dynamical model and executing the treatment action at the defined time point.

Abstract: Dose-volume criteria may be equivalently expressed in terms of quantiles. This re-formulation of a dose-volume criteria allows incorporation of dose-volume criteria into a full optimization problem. Radiotherapy treatment techniques are described that may apply optimization-based formulation of quantiles to express dose-volume criterion as an inequality involving an optimization problem, which may improve DVH modeling, improve computational speed and accuracy of radiation treatment planning, and improve the delivery accuracy and efficacy of radiation doses to a patient undergoing radiotherapy treatment.

Abstract: Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a radiotherapy treatment plan optimization problem; processing the radiotherapy treatment plan optimization problem with a machine learning model to estimate one or more optimization variables of the radiotherapy treatment plan optimization problem, wherein the machine learning model is trained to establish a relationship between the one or more optimization variables and parameters of a plurality of training radiotherapy treatment plan optimization problems; and generating a solution to the radiotherapy treatment plan optimization problem based on the estimated one or more optimization variables of the radiotherapy treatment plan optimization problem.

Abstract: Techniques for producing segmentation with privacy are provided.

Abstract: Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a first radiotherapy treatment plan optimization problem having a first set of parameters; processing the first set of parameters to estimate a second set of parameters of a second radiotherapy treatment plan optimization problem; generating a solution to the second radiotherapy treatment plan optimization problem based on the estimated second set of parameters; and generating a radiotherapy treatment plan based on the solution to the second radiotherapy treatment plan optimization problem.

Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving an input parameter related to a patient, the input parameter being of a given type; processing the input parameter with a machine learning technique to estimate a realizable plan parameter of a radiotherapy treatment plan, wherein the machine learning technique is trained to establish a relationship between the given type of input parameter and a set of realizable radiotherapy treatment plan parameters to achieve a target radiotherapy dose distribution; and generating the radiotherapy treatment plan based on the estimated realizable plan parameter.

Abstract: Techniques for generating a radiotherapy treatment plan parameter are provided. The techniques include receiving radiotherapy treatment plan information; processing the radiotherapy treatment plan information to estimate one or more radiotherapy treatment plan parameters based on a process that depends on the output of a subprocess that estimates a derivative of a dose calculation; and generating a radiotherapy treatment plan using the estimated one or more radiotherapy treatment plan parameters.

Abstract: Techniques for generating a radiotherapy treatment plan parameter are provided. The techniques include receiving radiotherapy treatment plan information; processing the radiotherapy treatment plan information to estimate one or more radiotherapy treatment plan parameters based on a process that depends on the output of a subprocess that estimates a derivative of a dose calculation; and generating a radiotherapy treatment plan using the estimated one or more radiotherapy treatment plan parameters.

Abstract: The present disclosure relates to systems, methods, and computer-readable storage devices for radiotherapy treatment planning. For example, a method may generate a treatment plan for a patient. The method may receive training data reflecting radiotherapy treatment data. The training data may include a feature vector and a target vector. The method may further determine a training model based on the feature vector and the target vector. The method may further receive testing data associated with the patient. The testing data may include a descriptive feature vector. The method may further determine a therapy model based on the descriptive feature vector and the training model. The therapy model may be used to generate the treatment plan.

Abstract: Systems and methods for calculating radiotherapy dose distribution are provided. The systems and methods include operations for receiving data representing at least one of particle trajectories or a dose deposition pattern in a simulated delivery of a radiotherapy plan; applying a dose calculation process to the received data to generate a first radiotherapy dose distribution having a first level of detail; and processing the first radiotherapy dose distribution using a trained machine learning technique to generate a second radiotherapy dose distribution having a second level of detail that enhances the first level of detail.

Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving a radiotherapy optimization problem, the radiotherapy problem comprising a plurality of parameters; processing the radiotherapy optimization problem to instantiate a first set of candidate parameters; converting the first set of candidate parameters into an adapted representation; defining an adapted radiotherapy optimization problem as a function of the adapted representation such that a given solution to the adapted optimization problem estimates a solution to the radiotherapy optimization problem; processing the adapted radiotherapy optimization problem to estimate a function of the solution to the adapted radiotherapy optimization problem; and processing the estimated function of the solution to the adapted optimization problem to generate a deliverable radiotherapy treatment plan.

Abstract: Techniques for generating a radiotherapy treatment plan parameter are provided. The techniques include receiving radiotherapy treatment plan information; processing the radiotherapy treatment plan information to estimate one or more radiotherapy treatment plan parameters based on a process that depends on the output of a subprocess that estimates a derivative of a dose calculation; and generating a radiotherapy treatment plan using the estimated one or more radiotherapy treatment plan parameters.

Abstract: Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a first radiotherapy treatment plan optimization problem having a first set of parameters; processing the first set of parameters to estimate a second set of parameters of a second radiotherapy treatment plan optimization problem; generating a solution to the second radiotherapy treatment plan optimization problem based on the estimated second set of parameters; and generating a radiotherapy treatment plan based on the solution to the second radiotherapy treatment plan optimization problem.

Abstract: Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a radiotherapy treatment plan optimization problem; processing the radiotherapy treatment plan optimization problem with a machine learning model to estimate one or more optimization variables of the radiotherapy treatment plan optimization problem, wherein the machine learning model is trained to establish a relationship between the one or more optimization variables and parameters of a plurality of training radiotherapy treatment plan optimization problems; and generating a solution to the radiotherapy treatment plan optimization problem based on the estimated one or more optimization variables of the radiotherapy treatment plan optimization problem.

Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving an input parameter related to a patient, the input parameter being of a given type; processing the input parameter with a machine learning technique to estimate a realizable plan parameter of a radiotherapy treatment plan, wherein the machine learning technique is trained to establish a relationship between the given type of input parameter and a set of realizable radiotherapy treatment plan parameters to achieve a target radiotherapy dose distribution; and generating the radiotherapy treatment plan based on the estimated realizable plan parameter.

Abstract: The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan.

Abstract: Techniques for the operation and use of a model that learns the general representation of multimodal images is disclosed. In various examples, methods from representation learning are used to find a common basis for representation of medical images. These include aspects of encoding, fusion, and downstream tasks, with use of the general representation and model. In an example, a method for generating a modality-agnostic model includes receiving imaging data, encoding the imaging data by mapping data to a latent representation, fusing the encoded data to conserve latent variables corresponding to the latent representation, and training a model using the latent representation. In an example, a method for processing imaging data using a trained modality-agnostic model includes receiving imaging data, encoding the data to the defined encoding, processing the encoded data with a trained model, and performing imaging processing operations based on output of the trained model.

Abstract: Systems and methods for calculating radiotherapy dose distribution are provided. The systems and methods include operations for receiving data representing at least one of particle trajectories or a dose deposition pattern in a simulated delivery of a radiotherapy plan; applying a dose calculation process to the received data to generate a first radiotherapy dose distribution having a first level of detail; and processing the first radiotherapy dose distribution using a trained machine learning technique to generate a second radiotherapy dose distribution having a second level of detail that enhances the first level of detail.