Abstract: A connection terminal for connecting a conductor is formed as a direct plug-in terminal and includes a clamping spring arranged in a housing. The clamping spring includes a resilient clamping leg which can move into an open and locking position by pressing down an actuating device. The housing contains a conductor insertion channel for insertion of the conductor into a clamping point between the free end of the clamping leg and a busbar. The actuating device includes a pressing element and a pivoting element which interacts with the pressing element at least when the clamping point is being opened. At least one release device is provided for releasing the locking state of the clamping leg of the clamping spring. The release device is designed in such a way that the locking position can be released again by the action of the conductor on the release device when it is inserted, wherein the pivoting element acts on the pressing element and the pressing element acts on the clamping leg.

Abstract: A laser system includes one or more harmonic generator blocks or elements including one or more crystals for converting a first wavelength (?1) laser beam into second, third and/or fourth wavelength (?2, ?3 and/or ?4) laser beams that may be output, with or without the first wavelength (?1) laser beam, on different beam paths. One or more of the first, second, third and/or fourth wavelength laser beams may travel or traverse in a crystal in one or multiple directions.

Abstract: The present disclosure relates generally to the field of analyzing a nucleic acid, such as RNA, in particular to the determination of at least one parameter of a sample composition comprising a nucleic acid, especially RNA, and optionally particles.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: A virucidal disinfectant or antiseptic is disclosed comprising 45-65 wt % of at least one alcohol, and 0.05-0.5 wt % of at least one phosphonate. The pH should be adjusted to lie between 3 and 10. Such disinfectant/antiseptic can be used for disinfecting a living or a non-living object and exhibits activity against a broad range of microorganisms such as viruses, fungi and/or bacteria, in particular against naked viruses such as polio.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: The present invention relates to an electrical connection system of a means for generating electrical energy from regenerative sources, in particular from a wind turbine, comprising a first connection piece which can be joined to an end of a first cable, a longitudinal axis of the first cable determining a first longitudinal axis and a second connection piece which can be joined to an end of a second cable or to a second end of the first cable, a longitudinal axis of the first or second cable determining a second longitudinal axis, wherein the first connection piece has a seat, formed for a projection of the second connection piece, and the second connection piece has the projection corresponding to the seat, and wherein the projection can be arranged in the seat to form an electrically conductive connection between the connection pieces.

Abstract: Electrical connection system, in particular of an underground cable, with a first connecting piece which can be connected to an end of a first cable, wherein a longitudinal axis of the first cable determines a first longitudinal axis, and a second connecting piece which can be connected to an end of a second cable, wherein a longitudinal axis of the second cable determines a second longitudinal axis, wherein the first connecting piece has a seat formed for a protrusion of the second connecting piece, and the second connecting piece has a protrusion corresponding to the seat, and wherein the protrusion can be arranged in the seat to form an electrically conductive connection between the connecting pieces. A particularly simple installation in the region of the underground cables is possible because the seat extends parallel to the first longitudinal axis, the protrusion extends parallel to the second longitudinal axis, and the protrusion can be pushed into the seat parallel to the first longitudinal axis.

Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are—useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.

Abstract: A virucidal disinfectant or antiseptic is disclosed comprising 45-65 wt % of at least one alcohol, and 0.05-0.5 wt % of at least one phosphonate. The pH should be adjusted to lie between 3 and 10. Such disinfectant/antiseptic can be used for disinfecting a living or a non-living object and exhibits activity against a broad range of microorganisms such as viruses, fungi and/or bacteria, in particular against naked viruses such as polio.

Abstract: Electrical connection system, in particular of an underground cable, with a first connecting piece which can be connected to an end of a first cable, wherein a longitudinal axis of the first cable determines a first longitudinal axis, and a second connecting piece which can be connected to an end of a second cable, wherein a longitudinal axis of the second cable determines a second longitudinal axis, wherein the first connecting piece has a seat formed for a protrusion of the second connecting piece, and the second connecting piece has a protrusion corresponding to the seat, and wherein the protrusion can be arranged in the seat to form an electrically conductive connection between the connecting pieces. A particularly simple installation in the region of the underground cables is possible because the seat extends parallel to the first longitudinal axis, the protrusion extends parallel to the second longitudinal axis, and the protrusion can be pushed into the seat parallel to the first longitudinal axis.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: The present invention relates to an electrical connection system of a means for generating electrical energy from regenerative sources, in particular from a wind turbine, comprising a first connection piece which can be joined to an end of a first cable, a longitudinal axis of the first cable determining a first longitudinal axis and a second connection piece which can be joined to an end of a second cable or to a second end of the first cable, a longitudinal axis of the first or second cable determining a second longitudinal axis, wherein the first connection piece has a seat, formed for a projection of the second connection piece, and the second connection piece has the projection corresponding to the seat, and wherein the projection can be arranged in the seat to form an electrically conductive connection between the connection pieces.

Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.

Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

Abstract: Device for electrically protecting an electric vehicle. To protect high voltage batteries of electric vehicles in the event of floods, a disconnecting device 6 for electrically disconnecting a vehicle battery 2 from an electric distribution system 8 within the vehicle and a detection device 4 for determining wetness are provided such that the detection device 4 activates the disconnecting device 6 if wetness 12 is detected, so that the vehicle battery 2 is electrically disconnected from the electric distribution system 8.

Abstract: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.