Abstract: The present invention relates to a pharmaceutical composition containing ?-lapachone as an active ingredient for prevention or treatment of cholestatic liver disease, and can provide agents for effectively preventing and treating cholestatic liver disease.

Abstract: A surface-emitting laser device according to an embodiment comprises: a first electrode; a substrate arranged on the first electrode; a first reflection layer arranged on the substrate; an active region arranged on the first reflection layer and including a cavity; an opening region arranged on the active region and including an aperture and an insulation region; a second reflection layer arranged on the opening region; a second electrode arranged on the second reflection layer; and a delta doping layer arranged in the opening region. The thickness of the insulation region becomes thinner in the direction of the aperture, and the delta doping layer can be arranged at the aperture.

Abstract: Disclosed is a nasal hair trimmer which removes a large amount of nose hair by safely inserting the nasal hair trimmer into a nostril using only a small number of operations. The nasal hair trimmer includes two cutting plates, each including two or three cutting heads and having a size capable of entering a nostril, wherein the two cutting plates are connected to each other by a shaft pin so as to swing while overlapping each other in a state of being parallel to each other, and wherein, when the cutting heads of the two cutting plates swing relative to each other, cutting heads neighboring each other are moved toward each other so as to cut nose hair.

Abstract: Disclosed is a pack. The pack includes a pack body in which fluid is receivable, a plug affixed to an inner surface of the pack body, a portion of the plug being configured to protrude outward from the pack body, the plug having a discharge opening perforated therein, a lid located at one side of the plug to close the discharge opening, and an elastic member located at one side of the plug to impart elasticity to the lid in a direction of closing the discharge opening.

Abstract: The present invention is related to a method for manufacturing a blade body of a nail clipper having a 3-dimensional inclined curve-type blade, including steps of forming an inclined curve with a curvature Ra using a boundary line which is formed when the periphery of grinding media with a radius Rg in an upright position is merged with an upper inclined surface having a predetermined angle ?1 with respect to a vertical line, forming a lower inclined surface by extending the inclined curve downward at an angle ?2 corresponding to the angle ?1, forming blade bodies using the upper and lower inclined surfaces to be inner inclined surfaces of the blade bodies, and grinding the ends of the upper and lower inclined surfaces simultaneously via grinding media with the radius Rg, whereby forming upper and lower 3-dimensional inclined curve-type blades with the curvature Ra, respectively.

Abstract: Disclosed is a dual pack. The dual pack includes a main body having an air pore for passage of air, a storage body configured to receive content therein, the storage body being located within the main body, and a water entrance/exit member configured to penetrate the main body and be connected to the interior of the storage body. The main body and the storage body are flexible, and an inner surface of the main body is separated from an outer surface of the storage body.

Abstract: Disclosed is a pack. The pack includes a pack body in which fluid is receivable, a plug affixed to an inner surface of the pack body, a portion of the plug being configured to protrude outward from the pack body, the plug having a discharge opening perforated therein, a lid located at one side of the plug to close the discharge opening, and an elastic member located at one side of the plug to impart elasticity to the lid in a direction of closing the discharge opening.

Abstract: The present invention is related to a method for manufacturing a blade body of a nail clipper having a 3-dimensional inclined curve-type blade, including steps of forming an inclined curve with a curvature Ra using a boundary line which is formed when the periphery of grinding media with a radius Rg in an upright position is merged with an upper inclined surface having a predetermined angle ?1 with respect to a vertical line, forming a lower inclined surface by extending the inclined curve downward at an angle ?2 corresponding to the angle ?1, forming blade bodies using the upper and lower inclined surfaces to be inner inclined surfaces of the blade bodies, and grinding the ends of the upper and lower inclined surfaces simultaneously via grinding media with the radius Rg, whereby forming upper and lower 3-dimensional inclined curve-type blades with the curvature Ra, respectively.

Abstract: Embodiments of the invention provide a nail clipper. The nail clipper comprises upper and lower blade members with a suitable length to hold by hand which face each other and form inner concave parts of the spoon shape; cutting blades that face each other at one end of the concave part; support shaft holes to the cutting blades; elastic parts extended to one side of each of the concave parts, which are joined at the end to consolidate the upper and lower blade members; and a lever located above the upper blade member and connected through upper and lower blade members via the supporting shaft.

Abstract: The present invention relates to a method of manufacturing arc type blades for a nail clipper, which corresponds to a curved surface of a finger nail, arc type blades and a nail clipper manufactured by the same.

Abstract: Embodiments of the invention provide a nail clipper. The nail clipper comprises upper and lower blade members with a suitable length to hold by hand which face each other and form inner concave parts of the spoon shape; cutting blades that face each other at one end of the concave part; support shaft holes to the cutting blades; elastic parts extended to one side of each of the concave parts, which are joined at the end to consolidate the upper and lower blade members; and a lever located above the upper blade member and connected through upper and lower blade members via the supporting shaft.

Abstract: A nail clipper of the invention comprises a nail clipper body having a rigidity and a suitable length to grip, and a lever mounted on an upper side of the body and a nail cutter mounted on a lower side of the body through a supporting shaft passing through a supporting shaft hole formed in one side end of the body. When a user grips the cutter, and rotates the cutter centering around the supporting shaft according to using direction, the cutter is rotated at a time within a range of 360° without interference of an obstacle to cut the nail at the desired angle.

Abstract: A nail clipper of the invention comprises a nail clipper body having a rigidity and a suitable length to grip, and a lever mounted on an upper side of the body and a nail cutter mounted on a lower side of the body through a supporting shaft passing through a supporting shaft hole formed in one side end of the body. When a user grips the cutter, and rotates the cutter centering around the supporting shaft according to using direction, the cutter is rotated at a time within a range of 360° without interference of an obstacle to cut the nail at the desired angle.

Abstract: Novel 2,4-pyrimidinedione compounds, and pharmaceutically acceptable salts thereof which possess good antiviral activities, and specifically represented by the following formula(I): ##STR1## wherein: R.sup.1 represents an unsubstituted or substituted allyl group represented by CH.sub.2 CH.dbd.CR.sup.5 R.sup.6 or an unsubstituted or substituted propargyl group represented by CH.sub.2 C.tbd.CR.sup.7 wherein R.sup.5, R.sup.6 and R.sup.7 are each independently a hydrogen atom; a methyl group optionally substituted with a halogen atom, or a C.sub.1-10 carbonyloxy, hydroxy, azido, cyano, optionally substituted amino, optionally substituted phosphonyl, optionally substituted phenyl, C.sub.3-10 heteroaryl, C.sub.1-3 alkoxy or benzyloxy radical; a C.sub.2-10 alkyl or alkenyl group; a cyclopropyl group; an optionally substituted phenyl group; a C.sub.3-10 heteroaryl group; a C.sub.1-10 ester group; or an optionally substituted C.sub.1-10 alkylamide group;R.sup.2 represents a halogen atom, an optionally substituted C.