Abstract: The disclosure relates to anti-cancer compounds derived from a payload which binds to poly(ADP-ribose) polymerase (PARP) and a nuclear steroid-targeting epitope (B of Formula I), which components are covalently linked via a linker, to products containing the same, as well as to methods of their use and preparation.

Abstract: A cryogenic tunnel freezer (10) having modular design and construction including a lower section (16) that can be raised and lowered relative to an upper section (14), the upper and lower sections (14, 16) defining a tunnel (12) when the lower section (16) is in a closed (raised) position. Product is moved through the tunnel (12) via a belt (22) formed of arrays of plastic modules (76) that are reinforced by metal chains (140) and rods (150). The lower run (23) of the belt (22) rides on the floor (48) of the lower section (16) and the upper run (21) rides on the lower run (23) when the belt (22) is operated. The flow of cryogenic fluid through the tunnel (12) is aided by vaporization of a cryogenic fluid and baffles (98), but no air-moving devices located within the tunnel (12).

Abstract: A cryogenic tunnel freezer (10) having modular design and construction including a lower section (16) that can be raised and lowered relative to an upper section (14), the upper and lower sections (14, 16) defining a tunnel (12) when the lower section (16) is in a closed (raised) position. Product is moved through the tunnel (12) via a belt (22) formed of arrays of plastic modules (76) that are reinforced by metal chains (140) and rods (150). The lower run (23) of the belt (22) rides on the floor (48) of the lower section (16) and the upper run (21) rides on the lower run (23) when the belt (22) is operated. The flow of cryogenic fluid through the tunnel (12) is aided by vaporization of a cryogenic fluid and baffles (98), but no air-moving devices located within the tunnel (12).

Abstract: A method for determining the flow rate of a fluid, having a liquid fraction and a gas fraction, having the steps of: measuring the pressure and temperature of the fluid at a flow control device through which said cyrogenic fluid passes; inputting the measured pressure and Cv into an algorithm; and performing a single or multi-step iteration to determine a fluid mass flow rate of the fluid through the flow control device using the algorithm that relates the mass flow rate of the fluid to the Cv, and mass densities of the liquid fraction and the gas fraction of the fluid which are a function of the measured pressure, and temperature. A system is also provided.

Abstract: A method of freezing a product, which method comprises the steps of vaporizing a cryogenic liquid and warming the vapor thus formed with a product to be frozen, characterized by using the warmed vapor thus obtained to cool compressed gaseous refrigerant in a mechanical refrigeration system before expansion thereof.

Abstract: A method of freezing a product, which method comprises the steps of vaporizing a cryogenic liquid and warming the vapor thus formed in indirect heat exchange with a product to be frozen, work expanding the warmed vapor, and using the work expanded vapor thus obtained to refrigerate the or another product.

Abstract: A method of cooling an aqueous liquid, which method comprises the steps of:a) placing said aqueous liquid in a vessel;b) reducing the pressure in said vessel to cause said aqueous liquid to boil;c) condensing at least some of the liquid in the vapour created as said aqueous liquid boils by heat exchange with a liquid cryogen; andd) using vapour from said liquid cryogen to at least assist in step (b).

Abstract: Method and apparatus for reclaiming sand from a foundry sand containing, inter alia, a clay binder by cooling the foundry sand to a temperature at or below -40.degree. C. (-40.degree. F.) followed by separation of the sand from the binder while the sand is maintained at a temperature at or below 0.degree. C. (32.degree. F.). Foundry sands with clay binders have a water content to 1% to 15% by weight prior to being cooled.