Patents by Inventor Jeremy Robert Greenwood

Jeremy Robert Greenwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS
    Publication number: 20240116892
    Abstract: The present disclosure provides heterocyclic amide and urea compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: August 7, 2023
    Publication date: April 11, 2024
    Inventors: Craig E. Masse, Kevin Robert DeMarco, Jiayi Xu, Jeremy R. Greenwood, Phani Ghanakota
  • HPK1 ANTAGONISTS AND USES THEREOF
    Publication number: 20240025898
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Application
    Filed: July 11, 2023
    Publication date: January 25, 2024
    Inventors: Neelu KAILA, Ian LINNEY, Stuart WARD, Grant WISHART, Ben WHITTAKER, Alexandre COTE, Jeremy Robert GREENWOOD, Abba LEFFLER, Steven K. ALBANESE, Daniel L. SEVERANCE
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230391797
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: December 23, 2022
    Publication date: December 7, 2023
    Inventors: Markus DAHLGREN, Jeremy Robert Greenwood, Geraldine c. Harriman, Joshua Jahmil Kennedy-Smith, Craig E. Masse, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • TYK2 inhibitors and uses thereof
    Patent number: 11834449
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: December 5, 2023
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jeremy Robert Greenwood, Craig E. Masse
  • HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20230365584
    Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 16, 2023
    Inventors: Xianhai HUANG, Sayan MONDAL, Phani GHANAKOTA, Nicholas BOYLES, Leah FRYE, Adam LEVINSON, Jeremy Robert GREENWOOD, Pieter BOS, Sathesh BHAT, Aleksey GERASYUTO, Haifeng TANG
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20230348424
    Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting certain protein- protein interactions, and for treating cancer.
    Type: Application
    Filed: February 3, 2023
    Publication date: November 2, 2023
    Inventors: Adam Marc Levinson, Evelyne Houang, Abba Elias Leffler, Andrew Placzek, Anatoly Ruvinsky, Jeremy Robert Greenwood, Zef Konst, Leah Frye
  • METHODS FOR PREDICTING AN ACTIVE SET OF COMPOUNDS HAVING ALTERNATIVE CORES, AND DRUG DISCOVERY METHODS INVOLVING THE SAME
    Publication number: 20230317214
    Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.
    Type: Application
    Filed: June 6, 2023
    Publication date: October 5, 2023
    Inventors: Robert L. Abel, Lingle Wang, Sathesh Bhat, Sayan Mondal, Jeremy Robert Greenwood, Kyle Konze
  • Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same
    Patent number: 11710543
    Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 25, 2023
    Assignee: Schrödinger, Inc.
    Inventors: Robert L. Abel, Lingle Wang, Sathesh Bhat, Sayan Mondal, Jeremy Robert Greenwood, Kyle Konze
  • SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS TYK2 INHIBITORS
    Publication number: 20230110996
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: June 14, 2022
    Publication date: April 13, 2023
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • CYCLIC COMPOUNDS AND METHODS OF USING SAME
    Publication number: 20230101747
    Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 30, 2023
    Inventors: Xianhai Huang, Sayan Mondal, Phani Ghanakota, Nicholas Boyles, Leah Frye, Aleksey Gerasyuto, Jeremy Robert Greenwood, Haifeng Tang, Adam Marc Levinson
  • CBL-B MODULATORS AND USES THEREOF
    Publication number: 20230086064
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.
    Type: Application
    Filed: April 8, 2022
    Publication date: March 23, 2023
    Inventors: Silvana Marcel LEIT DE MORADEI, Angela V. WEST, Thomas BAKER, Jokin Carrillo ARREGUI, Diana CASTAGNA, Jeremy Robert GREENWOOD, Salma RAFI, Fiona MCROBB, Yan ZHANG
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230074228
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 9, 2023
    Inventors: Craig E. MASSE, Jeremy Robert GREENWOOD, Donna L. ROMERO, Geraldine C. HARRIMAN, Ronald T. WESTER, Mee SHELLEY, Joshua Jahmil KENNEDY-SMITH, Markus DAHLGREN, Sayan MONDAL, Shaughnessy ROBINSON
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230056447
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: September 14, 2021
    Publication date: February 23, 2023
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. Mclean
  • HPK1 antagonists and uses thereof
    Patent number: 11548890
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: January 10, 2023
    Assignee: Nimbus Saturn, Inc.
    Inventors: Neelu Kaila, Ian Linney, Stuart Ward, Grant Wishart, Ben Whittaker, Alexandre Cote, Jeremy Robert Greenwood, Abba Leffler, Steven K. Albanese, Daniel L. Severance
  • HPK1 ANTAGONISTS AND USES THEREOF
    Publication number: 20220363695
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
    Type: Application
    Filed: March 29, 2022
    Publication date: November 17, 2022
    Inventors: Neelu KAILA, Ian LINNEY, Stuart WARD, Grant WISHART, Benjamin WHITTAKER, Alexandre COTE, Jeremy Robert GREENWOOD, Abba LEFFLER
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220356184
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: March 23, 2021
    Publication date: November 10, 2022
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 11434240
    Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: September 6, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Donna L. Romero, Geraldine C. Harriman, Ronald T. Wester, Mee Shelley, Joshua Jahmil Kennedy-Smith, Markus Dahlgren, Sayan Mondal, Shaughnessy Robinson
  • Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Patent number: 11414431
    Abstract: The present invention provides compounds of Formula I?: compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 16, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • TYK2 inhibitors and uses thereof
    Patent number: 11396508
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 26, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220106306
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: May 14, 2021
    Publication date: April 7, 2022
    Inventors: Jeremy Robert GREENWOOD, Craig E. MASSE