Abstract: A computer aided detection (CAD) method for detecting polyps within an identified mucosa layer of a virtual representation of a colon includes the steps of identifying candidate polyp patches in the surface of the mucosa layer and extracting the volume of each of the candidate polyp patches. The extracted volume of the candidate polyp patches can be partitioned to extract a plurality of features, of the candidate polyp patch, which includes at least one internal feature of the candidate polyp patch. The features can include density texture features, geometrical features, and morphological features of the polyp candidate volume. The extracted features of the polyp candidates are analyzed to eliminate false positives from the candidate polyp patches. Those candidates which are not eliminated are identified as polyps.