Abstract: Apparatus for treatment of anatomical structure having a lumen includes a pressure differential device adapted to move the anatomical structure to a desired configuration for treatment by creating a pressure differential with respect to the lumen of the anatomical structure, a biological adhesive dispenser, operably coupled with the pressure differential device, and biological adhesive adapted for dispensing by the dispenser and adapted to stabilize the anatomical structure in the desired configuration. A dispenser for applying adhesive to an anatomical structure includes a penetrator adapted to rotate into or around the anatomical structure, and a driver adapted to rotate in one direction to rotate the penetrator into or around the anatomical structure, and adapted to rotate in a direction opposite to the one direction to withdraw the penetrator from the anatomical structure, wherein the penetrator is adapted to apply adhesive to the anatomical structure.