Patents by Inventor Jerome Anthony Werkmeister

Jerome Anthony Werkmeister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220040371
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 10, 2022
    Applicant: Cook Medical Technologies LLC
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Patent number: 11097033
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: August 24, 2021
    Assignee: Cook Medical Technologies LLC
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Patent number: 10155793
    Abstract: The present disclosure relates to recombinant or synthetic collagen-like proteins comprising at least one triple-helical domain and wherein the collagen-like protein is modified compared to a native bacterial collagen-like sequence.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: December 18, 2018
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: John Alan Maurice Ramshaw, Jerome Anthony Werkmeister, Violet Stoichevska, Yong Yi Peng
  • Patent number: 10053501
    Abstract: The present invention relates to a method for purifying triple-helical or collagen-like proteins recombinantly produced from a bacterial, yeast or plant host cell.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: August 21, 2018
    Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: John Alan Maurice Ramshaw, Jerome Anthony Werkmeister, Yong Yi Peng
  • Publication number: 20160376326
    Abstract: The present disclosure relates to recombinant or synthetic collagen-like proteins comprising at least one triple-helical domain and wherein the collagen-like protein is modified compared to a native bacterial collagen-like sequence.
    Type: Application
    Filed: September 9, 2014
    Publication date: December 29, 2016
    Inventors: John Alan Maurice Ramshaw, Jerome Anthony Werkmeister, Violet Stoichevska, Yong Yi Peng
  • Publication number: 20160114075
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Application
    Filed: November 16, 2015
    Publication date: April 28, 2016
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Publication number: 20160046692
    Abstract: The present invention relates to a method for purifying triple-helical or collagen-like proteins recombinantly produced from a bacterial, yeast or plant host cell.
    Type: Application
    Filed: March 21, 2014
    Publication date: February 18, 2016
    Inventors: John Alan Maurice Ramshaw, Jerome Anthony Werkmeister, Yong Yi Peng
  • Patent number: 9216235
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: December 22, 2015
    Assignee: Cook Medical Technologies LLC
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Patent number: 8445581
    Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: May 21, 2013
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
  • Publication number: 20110190813
    Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.
    Type: Application
    Filed: August 14, 2008
    Publication date: August 4, 2011
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Charles Mark Lindall
  • Publication number: 20090324675
    Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
    Type: Application
    Filed: August 2, 2007
    Publication date: December 31, 2009
    Applicant: POLYNOVO BIOMATERIALS PTY LIMITED
    Inventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
  • Publication number: 20090098177
    Abstract: Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells an/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis.
    Type: Application
    Filed: November 13, 2008
    Publication date: April 16, 2009
    Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH INSTITUTE, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jerome Anthony Werkmeister, Wei-Bor Tsai, John Alan Maurice Ramshaw, Helmut Werner Thissen, Ken-Yuan Chang
  • Publication number: 20080139477
    Abstract: The invention relates to a method for producing hydroxylated triple helical proteins in yeast host cells by introducing to a suitable yeast host cell, DNA sequences encoding the triple helical protein as well as prolyl 4-hydroxylase (PH4), in a manner wherein the introduced DNA sequences are replicated, stably retained and segregated by the yeast host cells.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Inventors: Paul Richard Vaughan, Maria Galanis, John Alan Maurice Ramshaw, Jerome Anthony Werkmeister
  • Publication number: 20030064436
    Abstract: The invention relates to a method for producing hydroxylated triple helical proteins in yeast host cells by introducing to a suitable yeast host cell, DNA sequences encoding the triple helical protein as well as prolyl 4-hydroxylase (PH4), in a manner wherein the introduced DNA sequences are replicated, stably retained and segregated by the yeast host cells.
    Type: Application
    Filed: December 21, 2001
    Publication date: April 3, 2003
    Inventors: Paul Richard Vaughan, Maria Galanis, John Alan Maurice Ramshaw, Jerome Anthony Werkmeister
  • Patent number: 6451557
    Abstract: A method for producing a hydroxylated triple helical protein is disclosed, as well as a yeast host cell used in the method. The method comprises culturing a yeast host cell comprising: (1) a first DNA molecule comprising a DNA sequence encoding P4H&agr; subunit operably linked to a promoter functional in the yeast host cell, (2) a second DNA molecule comprising a DNA sequence encoding P4H&agr; subunit operably linked to a promoter functional in the yeast host cell, and (3) a third DNA molecule comprising a DNA sequence encoding a polypeptide or peptide operably linked to a promoter functional in the yeast host cell, wherein the polypeptide or peptide is one which, when hydroxylated, forms the hydroxylated triple helical protein; and wherein during culturing, each of the first DNA molecule, the second DNA molecule and the third DNA molecule are replicated, stably retained and segregated.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: September 17, 2002
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Paul Richard Vaughan, Maria Galanis, John Alan Maurice Ramshaw, Jerome Anthony Werkmeister