Patents by Inventor Jerome Chal

Jerome Chal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of brown adipose tissue from pluripotent stem cells in vitro
    Patent number: 11390850
    Abstract: A population of Brown adipose tissue (BAT) cells generated from embryonic stem cells (ES) or induced pluripotent stem cells (iPS), called iBAT, the use thereof, methods to obtain iBAT by directed differentiation of ES/iPS, and media compositions to obtain iBAT.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 19, 2022
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Olivier Pourquie, Jerome Chal
  • Generation of Brown Adipose Tissue from Pluripotent Stem Cells in Vitro
    Publication number: 20190203177
    Abstract: A population of Brown adipose tissue (BAT) cells generated from embryonic stem cells (ES) or induced pluripotent stem cells (iPS), called iBAT, the use thereof, methods to obtain iBAT by directed differentiation of ES/iPS, and media compositions to obtain iBAT.
    Type: Application
    Filed: June 23, 2017
    Publication date: July 4, 2019
    Inventors: Olivier Pourquie, Jerome Chal
  • Method for preparing induced paraxial mesoderm progenitor (IPAM) cells and their use
    Patent number: 10240123
    Abstract: The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: March 26, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE), UNIVERSITE DE STRASBOURG, ASSOCIATION FRANCAISE CONTRE LE MYOPATHIES
    Inventors: Olivier Pourquie, Jérôme Chal
  • METHOD FOR PREPARING INDUCED PARAXIAL MESODERM PROGENITOR (IPAM) CELLS AND THEIR USE
    Publication number: 20140363886
    Abstract: The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.
    Type: Application
    Filed: August 29, 2012
    Publication date: December 11, 2014
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES, UNIVERSITE DE STRASBOURG, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)
    Inventors: Olivier Pourquie, Jérôme Chal
  • INDUCED PRESOMITIC MESODERM (IPSM) CELLS AND THEIR USE
    Publication number: 20140127169
    Abstract: The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues.
    Type: Application
    Filed: January 24, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE DE STRASBOURG, STOWERS INSTITUTE FOR MEDICAL RESEARCH, ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES
    Inventors: Olivier Pourquie, Matthias Wahl, Jerome Chal
  • METHOD FOR PREPARING INDUCED PARAXIAL MESODERM PROGENITOR (IPAM) CELLS AND THEIR USE
    Publication number: 20130052729
    Abstract: An ex vivo method for preparing a population of induced paraxial mesoderm progenitor (iPAM) cells includes culturing pluripotent cells in an appropriate culture medium that includes an effective amount of an activator of the Wnt signalling pathway.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Inventors: Olivier Pourquie, Jerome Chal