Patents by Inventor Jerome Pinkner

Jerome Pinkner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STRUCTURAL BASIS FOR OUTER MEMBRANE USHER ACTIVATION TO CATALYZE P PILUS ASSEMBLY
    Publication number: 20200345707
    Abstract: Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that disrupt the intramolecular interactions of the pilus subunits thereby reducing pilus assembly.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 5, 2020
    Inventors: Scott HULTGREN, Natalie OMATTAGE, Fredrik ALMQVIST, Jerome PINKNER, Karen DODSON, Peng YUAN
  • Compositions and methods for the treatment and prevention of Ebp pilus-related diseases
    Patent number: 10449242
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: October 22, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES
    Publication number: 20180055923
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Application
    Filed: November 13, 2017
    Publication date: March 1, 2018
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • Compositions and methods for the treatment and prevention of Ebp pilus-related diseases
    Patent number: 9839682
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 12, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES
    Publication number: 20160074498
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 17, 2016
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • Amino methylated 2-pyridinones
    Publication number: 20070082887
    Abstract: Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit adherence of bacteria to a host cell.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 12, 2007
    Applicant: Washington University
    Inventors: Scott Hultgren, Jerome Pinkner, Fredrik Almqvist, Nils Pemberton, Veronica Aberg, Andreas Larsson