Patents by Inventor Jerome Puginier
Jerome Puginier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130101520Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.Type: ApplicationFiled: September 12, 2012Publication date: April 25, 2013Applicant: Bracco Suisse S.A.Inventors: Michel SCHNEIDER, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
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Publication number: 20120093732Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.Type: ApplicationFiled: September 1, 2011Publication date: April 19, 2012Applicant: Bracco Suisse S.A.Inventors: Michel Schneider, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
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Publication number: 20080063603Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.Type: ApplicationFiled: September 7, 2007Publication date: March 13, 2008Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
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Publication number: 20060257321Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: June 1, 2006Publication date: November 16, 2006Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Patent number: 7083778Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: GrantFiled: March 12, 2003Date of Patent: August 1, 2006Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, legal representative, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
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Publication number: 20060034771Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: September 22, 2005Publication date: February 16, 2006Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Maria Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Patent number: 6989141Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: April 12, 2002Date of Patent: January 24, 2006Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Gercel, legal representative, Jerome Puginier, Maria-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
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Publication number: 20050207980Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: ApplicationFiled: March 22, 2005Publication date: September 22, 2005Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Patent number: 6896875Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: GrantFiled: August 23, 2002Date of Patent: May 24, 2005Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier
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Patent number: 6881397Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: February 4, 2002Date of Patent: April 19, 2005Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jèróme Puginier, Marie-Bernadette Barrau, Pascal Grenier
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Publication number: 20050058605Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: October 13, 2004Publication date: March 17, 2005Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau
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Publication number: 20040208826Abstract: Gas or air filled microbubble and microballoon suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. The microbubble suspensions contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The microbubble suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. The microballoons have a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick polymer membrane. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles and gas-filled microballoons used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: March 26, 2004Publication date: October 21, 2004Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Publication number: 20040180004Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed are methods of preparation of the stable suspensions of gas filled microbubbles, as well as dry formulations which, upon reconstitution in an aqueous carrier liquid, will form the injectable suspensions of gas filled microbubbles of the invention and methods of making and using the same The preferred dry formulations are stable when stored over time and at temperatures above ambient temperature and further comprise a lipid acid preserving agent additive.Type: ApplicationFiled: February 20, 2004Publication date: September 16, 2004Applicant: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Publication number: 20030194376Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: January 6, 2003Publication date: October 16, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Publication number: 20030185759Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: January 6, 2003Publication date: October 2, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Publication number: 20030175211Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: March 12, 2003Publication date: September 18, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Nadine Garcel
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Patent number: 6613306Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: GrantFiled: September 22, 1999Date of Patent: September 2, 2003Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Patent number: 6592846Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: May 12, 2000Date of Patent: July 15, 2003Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jérôme Puginier, Marie-Bernadette Barrau
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Publication number: 20030129137Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarize phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: ApplicationFiled: January 31, 2003Publication date: July 10, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: RE39146Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: July 15, 1998Date of Patent: June 27, 2006Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier