Patents by Inventor Jerrold M. Liesch

Jerrold M. Liesch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal agents
    Patent number: 5770587
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: June 23, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente, Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Otto D. Hensens, Jerrold M. Liesch, Rosalind G. Jenkins, John R. Thompson
  • Antifungal agent obtained from hormonema
    Patent number: 5756472
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: May 26, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Sandra A. Morris, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Wendy S. Horn, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agent produced by arthrinium arundinis ATCC 74359
    Patent number: 5712109
    Abstract: There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: January 27, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agents
    Patent number: 5543429
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: August 6, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, James E. Curotto, Sarah J. Dreikorn, Rosalind G. Jenkins, Jerrold M. Liesch, Sandra A. Morris, John R. Thompson, Deborah L. Zink, Richard K. Jansson, Angela Basilio, Teresa Diez, Fernando Pelaez, Francisca Vicente
  • Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .beta. inventory enzyme
    Patent number: 5411985
    Abstract: Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: May 2, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Otto D. Hensens, Jerrold M. Liesch, Russel B. Lingham, Jon D. Polishook, Michael J. Salvatore, Susan L. Raghoobar
  • Antibiotic agent
    Patent number: 5366880
    Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: November 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Prakash S. Masurekar, David F. Sesin, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
  • Antibiotic agent
    Patent number: 5306708
    Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: April 26, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, David F. Sesin, Prakash S. Masurekar, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
  • Anthelmintic milbemycin analogs of novel microorganisms
    Patent number: 5290804
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: March 1, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert T. Goegelman, Elvira Munguira, Maria T. Diez Matas, Ruth S. Sykes, Yu L. Kong, Jerrold M. Liesch, Gregory L. Helms, E. Tracy Turner Jones
  • Antibiotic eicosenoic acids
    Patent number: 5233062
    Abstract: New antibiotic eicosenoic acids and a method of producing it are described. The acids have been found to have antifungal properties.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: August 3, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Wendy S. Horn, Myra B. Kurtz, Jerrold M. Liesch, Jack L. Smith, Isabel Martin, Francisca Vicente
  • Antibiotic cyclopeptide fermentation product
    Patent number: 5202309
    Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: April 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Jerrold M. Liesch, Raymond F. White, Otto D. Hensens, Henry Joshua, Dennis M. Schmatz
  • Antifungal substances and process for their production
    Patent number: 5130445
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds structures are presented based upon analytical studies. The compounds have antifungal activity.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: July 14, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Richard W. Burg, Jerrold M. Liesch, Otto D. Hensens, Sebastian Hernandez
  • Novel squalene synthetase inhibitors
    Patent number: 5096923
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: March 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Leeyuan Huang, Jerrold M. Liesch, Janet C. Onishi, Frank L. Vanmiddlesworth
  • Oxytocin and vasopressin antagonists
    Patent number: 5095003
    Abstract: Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
    Type: Grant
    Filed: October 23, 1990
    Date of Patent: March 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Michael A. Goetz, Lawrence R. Koupal, Cheryl D. Schwartz, Jerrold M. Liesch, Otto D. Hensens, Paul S. Anderson, Roger Freidinger, Douglas J. Pettibone
  • Lipophilic macrolide useful as an immunosuppressant
    Patent number: 5093338
    Abstract: Disclosed is a novel lipophilic macrolide of Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: March 3, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Kevin Byrne, Robert T. Goegelman, Otto Hensens, Louis Kaplan, Jerrold M. Liesch
  • Novel HMG-CoA synthase inhibitors
    Patent number: 5064856
    Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
  • Antibiotic agents
    Patent number: 5049546
    Abstract: A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: September 17, 1991
    Assignee: Merck & Co., Inc.
    Inventors: David F. Sesin, Jerrold M. Liesch, Jimmy M. Fountoulakis, Prakash S. Masurekar, Louis Kaplan, Carol F. Wichmann
  • Novel antifungal substances and process for their production
    Patent number: 5028537
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: July 2, 1991
    Assignee: Merck & Co. Inc.
    Inventors: Richard W. Burg, Otto D. Hensens, Jerrold M. Liesch, Sebastian Hernandez, Lucille J. Cole
  • Antibiotic agents
    Patent number: 5021403
    Abstract: A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: June 4, 1991
    Assignee: Merck & Co., Inc.
    Inventors: David F. Sesin, Jerrold M. Liesch, Jimmy M. Fountoulakis, Prakash S. Masurekar, Louis Kaplan, Carol F. Wichmann
  • Antifungal agent
    Patent number: 4952604
    Abstract: Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: August 28, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Otto D. Hensens, Jerrold M. Liesch, James A. Milligan, Sagrario M. Del Val, Robert E. Schwartz, Carol Wichmann
  • Antifungal fermentation product and method
    Patent number: 4946835
    Abstract: A novel dioxa-diazacyclohexadecenetetrone isolated from the fermentation of a cyanobacterium (Nostoc sp.) is described. The compound is a new antifungal agent with a specificity generally toward filamentous fungi but also effective against Cryptococcus sp.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: August 7, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Charles F. Hirsch, Jerrold M. Liesch, Michael J. Salvatore, Robert E. Schwartz, David F. Sesin