Abstract: A user interface controller for use by physically challenged persons has multiple function capabilities to operate an electronic device such as a computer or video game system. The controller provides activation of a plurality of first type control devices through a first type movement of a mouthpiece actuator, selection of one or more banks of second type control devices through a second different type movement of the mouthpiece, and activation of one or more second control devices within a selected bank of second control devices through puff and sip operations performed through the mouthpiece.