Abstract: A needle cap replacement device for the purpose of removing, holding and replacing a protective needle cover or cap during the performance of a medical procedure involving a needle and syringe. The needle cap replacement device comprises a block of suitable material having at least one recess wherein the recess has a diameter and a depth for receipt and retention of the needle cap; an elongated cap covering the needle and releasably attached to the distal portion of a syringe. The needle cap replacement device may have more than one recess for the receipt and retention of several needle caps and the recesses may be of varying diameters to accommodate caps of varying sizes. The device may have a disposal chamber for the syringe and needle. Attached to the replacement device at the exterior of the disposal chamber is a receptacle to receive the used needles and syringes.