Patents by Inventor Jerzy A. Macioszek
Jerzy A. Macioszek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190049378Abstract: A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures. In the method, a first plurality of reaction mixtures are provided to a heater and subjected to conditions for performing a first amplification reaction. The presence or amount of a first target nucleic acid in each of the first plurality of reaction mixtures is determined during the first amplification reaction. During the first amplification reaction, a second plurality of reaction mixtures are provided to the heater and subjected to conditions for performing a second amplification reaction. The presence or amount of a second target nucleic acid in each of the second plurality of reaction mixtures is determined during the second amplification reaction. At least a portion of the second plurality of reaction mixtures are removed from the heater during the second amplification reaction.Type: ApplicationFiled: June 21, 2018Publication date: February 14, 2019Inventors: Gary D. LAIR, Thanh N. NGUYEN, Haitao LI, Florence LI, Byron J. KNIGHT, Robert E. HEINZ, Jerzy A. MACIOSZEK, Christopher B. DAVIS, Robert F. SCALESE
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Patent number: 10006862Abstract: A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater.Type: GrantFiled: May 19, 2017Date of Patent: June 26, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence Li, Byron J. Knight, Robert E. Heinz, Jerzy A. Macioszek, Christopher B. Davis, Robert F. Scalese
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Publication number: 20170261431Abstract: A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater.Type: ApplicationFiled: May 19, 2017Publication date: September 14, 2017Inventors: Gary D. LAIR, Thanh N. NGUYEN, Haitao LI, Florence LI, Byron J. KNIGHT, Robert E. HEINZ, Jerzy A. MACIOSZEK, Christopher B. DAVIS, Robert F. SCALESE
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Patent number: 8349564Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: November 4, 2010Date of Patent: January 8, 2013Assignee: Gen-Probe IncorporatedInventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
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Patent number: 8008066Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: August 30, 2011Assignee: Gen-Probe IncorporatedInventors: Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert E. Heinz, Jerzy A. Macioszek, Christopher B. Davis, Robert F. Scalese
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Publication number: 20110147610Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: February 22, 2011Publication date: June 23, 2011Applicant: GEN-PROBE INCORPORATEDInventors: Jerzy A. MACIOSZEK, Christopher B. DAVIS, Gary D. LAIR, Thanh N. NGUYEN, Haitao LI, Florence F. LI, Byron J. KNIGHT, Robert F. SCALESE, Robert E. HEINZ
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Patent number: 7964413Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: June 21, 2011Assignee: Gen-Probe IncorporatedInventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
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Patent number: 7932081Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: April 26, 2011Assignee: Gen-Probe IncorporatedInventors: Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert E. Heinz, Jerzy A. Macioszek, Christopher B. Davis, Robert F. Scalese
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Publication number: 20110053169Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: November 4, 2010Publication date: March 3, 2011Applicant: GEN-PROBE INCORPORATEDInventors: Jerzy A. MACIOSZEK, Christopher B. DAVIS, Gary D. LAIR, Thanh N. NGUYEN, Haitao LI, Florence F. LI, Byron J. KNIGHT, Robert F. SCALESE, Robert E. HEINZ
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Patent number: 7897337Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: March 1, 2011Assignee: Gen-Probe IncorporatedInventors: Jerzy A. Macioszek, Christopher B. Davis, Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert F. Scalese, Robert E. Heinz
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Patent number: 7794659Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: GrantFiled: March 10, 2006Date of Patent: September 14, 2010Assignee: Gen-Probe IncorporatedInventors: Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence F. Li, Byron J. Knight, Robert E. Heinz, Jerzy A. Macioszek, Christopher B. Davis, Robert F. Scalese
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Publication number: 20070243600Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: March 10, 2006Publication date: October 18, 2007Applicant: GEN-PROBE INCORPORATEDInventors: Gary Lair, Thanh Nguyen, Haito Li, Florence Li, Byron Knight, Robert Heinz, Jerzy Macioszek, Christopher Davis, Robert Scalese
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Publication number: 20070004028Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: March 10, 2006Publication date: January 4, 2007Applicant: GEN-PROBE INCORPORATEDInventors: Gary Lair, Thanh Nguyen, Haito Li, Florence Li, Byron Knight, Robert Heinz, Jerzy Macioszek, Christopher Davis, Robert Scalese
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Publication number: 20060211130Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: March 10, 2006Publication date: September 21, 2006Applicant: Gen-Probe IncorporatedInventors: Jerzy Macioszek, Christopher Davis, Gary Lair, Thanh Nguyen, Haitao Li, Florence Li, Byron Knight, Robert Scalese, Robert Heinz
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Publication number: 20060210433Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: March 10, 2006Publication date: September 21, 2006Applicant: GEN-PROBE INCORPORATEDInventors: Gary Lair, Thanh Nguyen, Haito Li, Florence Li, Byron Knight, Robert Heinz, Jerzy Macioszek, Christopher Davis, Robert Scalese
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Publication number: 20060204997Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.Type: ApplicationFiled: March 10, 2006Publication date: September 14, 2006Applicant: Gen-Probe IncorporatedInventors: Jerzy Macioszek, Christopher Davis, Gary Lair, Thanh Nguyen, Haitao Li, Florence Li, Byron Knight, Robert Scalese, Robert Heinz
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Patent number: 5968739Abstract: Nucleic acid sequences that are useful for detecting Legionella pneumophila are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Legionella pneumophila in a test sample. Additionally, the sequences can be provided as part of a kit.Type: GrantFiled: December 10, 1996Date of Patent: October 19, 1999Assignee: Abbott LaboratoriesInventors: Jerzy A. Macioszek, Bor-Chian Lin, Arthur E. Martinez
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Patent number: 5698393Abstract: A method for treating biological samples, e.g., human sera or plasma, suspected of containing rheumatoid factors to eliminate cross-reactivity and false positive assay results in IgM immunoassays that are caused by the presence of rheumatoid factors in these biological samples. In one aspect, the method comprises diluting a biological sample with a sufficient amount of rheumatoid factor neutralization buffer to cause the pH of resulting reaction mixtures containing this sample and a solid phase material to be sufficiently low to cause rheumatoid factors in those mixtures to reduce their affinity to IgG antibodies to such an extent that they will not form a complex with IgG antibodies bound to the solid phase material, thereby facilitating the removal of these rheumatoid factors from the mixtures prior to the detection phase of a diagnostic assay.Type: GrantFiled: August 18, 1995Date of Patent: December 16, 1997Assignee: Abbott LaboratoriesInventors: Jerzy A. Macioszek, John M. Robinson