Patents by Inventor Jessica Godin Karp
Jessica Godin Karp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826760Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: GrantFiled: July 15, 2022Date of Patent: November 28, 2023Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11821891Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 7, 2020Date of Patent: November 21, 2023Assignee: General Electric CompanyInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20220347691Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: ApplicationFiled: July 15, 2022Publication date: November 3, 2022Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11446671Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: GrantFiled: March 14, 2017Date of Patent: September 20, 2022Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20210088503Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 10859563Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 1, 2015Date of Patent: December 8, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20190091696Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: ApplicationFiled: March 14, 2017Publication date: March 28, 2019Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20170153223Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 1, 2015Publication date: June 1, 2017Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 9150907Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.Type: GrantFiled: May 15, 2014Date of Patent: October 6, 2015Assignee: General Electric CompanyInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Patent number: 9080941Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.Type: GrantFiled: May 14, 2014Date of Patent: July 14, 2015Assignee: General Electric CompanyInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Publication number: 20140248617Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.Type: ApplicationFiled: May 14, 2014Publication date: September 4, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Publication number: 20140248618Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner