Patents by Inventor Jessica Shu

Jessica Shu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-polymer lipid-peptide conjugates and nanoparticles thereof
    Patent number: 10806702
    Abstract: The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: October 20, 2020
    Assignee: The Regents of the University of California
    Inventors: Ting Xu, He Dong, Jessica Shu, Nikhil Dube
  • BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
    Publication number: 20190015328
    Abstract: The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
    Type: Application
    Filed: April 24, 2018
    Publication date: January 17, 2019
    Inventors: Ting Xu, He Dong, Jessica Shu, Nikhil Dube
  • Bis-polymer lipid-peptide conjugates and nanoparticles thereof
    Patent number: 9949927
    Abstract: The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: April 24, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ting Xu, He Dong, Jessica Shu, Nikhil Dube
  • BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF
    Publication number: 20170049901
    Abstract: The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
    Type: Application
    Filed: September 18, 2014
    Publication date: February 23, 2017
    Inventors: Ting Xu, He Dong, Jessica Shu, Nikhil Dube
  • LIPID-PEPTIDE-POLYMER CONJUGATES AND NANOPARTICLES THEREOF
    Publication number: 20160009770
    Abstract: The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
    Type: Application
    Filed: April 29, 2015
    Publication date: January 14, 2016
    Inventors: Ting Xu, He Dong, Jessica Shu
  • Lipid-peptide-polymer conjugates and nanoparticles thereof
    Patent number: 9044514
    Abstract: The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: June 2, 2015
    Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ting Xu, He Dong, Jessica Shu
  • Lipid-Peptide-Polymer Conjugates and Nanoparticles Thereof
    Publication number: 20130121917
    Abstract: The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
    Type: Application
    Filed: September 11, 2012
    Publication date: May 16, 2013
    Applicant: Lawrence Berkeley National Laboratory
    Inventors: Ting Xu, He Dong, Jessica Shu