Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

Abstract: One example method of testing an electrical device comprises transmitting a data pattern to a memory device of the electrical device by a controller of the electrical device to provide a written data pattern to the memory device, wherein the data pattern replicates a resonant frequency of at least a portion of the electrical device, reading the written data pattern from the memory device with the controller, and comparing the written data pattern to the data pattern.

Abstract: A tunnel operation robot includes a robot body, a walking module, a fixed wing module and a plurality of rotatable wing modules. Both sides of the robot body are provided with cantilever parts, which are collinearly arranged. The walking module is arranged on the robot body. The fixed wing module includes a fixed fan, is fixedly arranged on the robot body, and is configured to provide a pressure for the walking module to be attached to and pressed against the tunnel wall surface. The plurality of rotatable wing modules are respectively arranged on the cantilever parts on both sides of the robot body, and include a rotatable rotating fan and a wind direction adjustment driver. Each rotating fan has a rotation axis parallel to the cantilever parts and an air outlet direction perpendicular to the cantilever parts, and the wind direction adjustment driver is connected to the rotating fan.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A three-stage tubular T-shaped degassing device with microbubble axial flow and spiral flow fields is provided, which is applied to quick degassing of a gas-liquid two-phase flow. The three-stage tubular T-shaped degassing device adopts a quick degassing technology combining a microbubble uniform mixed rotational axial flow field and a spiral runner conical spiral flow field with layered jet collision reversing depth degassing. A microbubble uniform mixer is configured to adjust gas-liquid two-phase flow containing big bubbles into microbubble uniform mixed axial flow. A microbubble cyclone is configured to adjust the microbubble uniform mixed axial flow into multiple strands of rotational axial flows containing microbubbles. A rotational axial flow degasser implements the horizontal type microbubble uniform mixed multiple strands rotational axial flow degassing operation to remove most microbubbles to form axial flow gas and axial flow liquid.

Abstract: The present invention provides a method for treating a used particulate filter, comprising: removing particulates from the particulate filter; and introducing simulated ash into inlet channels of the particulate filter after removing the particulates.

Abstract: The invention relates to inhibitors of ROCK1 and/or ROCK2 having the formula I: Also provided are methods of inhibiting ROCK1 and/or ROCK2 useful for the treatment of disease.

Abstract: A folding pallet truck comprises a frame module, a lifting module installed on the frame module and comprising a mount, and a handle module comprising a tube in rotating fit with the mount, wherein a first constraint part is formed between an end, rotatably connected to the mount, of the tube and the mount, and the handle module is folded by detaching the first constraint part or is unfolded by reassembling the first constraint part. The handle module can be folded to be stored or be unfolded and locked to be used by detaching or reassembling the first constraint part formed between the tube of the handle module and the mount of the lifting module, operation is easy, and the pallet truck has a small size when stored.

Abstract: Provided is a noninvasive hemoglobin detector, including an image acquisition system, an image processing and analysis system and a printing device. The image acquisition system is connected with the image processing and analysis system, and the image acquisition system is used for acquiring, transmitting and storing an image to be tested. The image processing and analysis system is further connected with the printing device, and the image processing and analysis system is used for processing and analyzing the image to be tested to obtain an analysis result. The printing device is used for printing the image to be tested and the analysis result.

Abstract: A method includes receiving a trajectory dataset including a plurality of geospatial points forming a point cloud and acquired along a trajectory wherein for each of the plurality of geospatial points there is a defined an x-coordinate, a y-coordinate and a z-coordinate and at least one mapping device orientation attribute, segmenting the trajectory dataset into a plurality of segments, determining at least one relative constraint for each of the plurality of segments and utilizing, for each of the plurality of segments, at least one of the determined relative constraints to determine a relative position of at least two of the plurality of segments.

Abstract: A diabetes detection method for forensic identification includes the following steps. A sample kidney tissue slice is obtained and processed to obtain initial processing data; the initial processing data are input into a convolutional neural network model for training to obtain target processing data, and training database is obtained based on the target processing data; based on the target processing data in the training database, the sample kidney tissue slice is detected for diabetes, and a forensic identification test report is generated and displayed. The method can solve problems caused by a use of a chemical staining method in a diagnosis of diabetes, provide helps for a forensic pathological cause of death identification, realize scientific identification, ensure the correct trial and judgment of cases, improve the work efficiency of criminal investigators and the accuracy of identification results, and maintain the justice of laws.

Abstract: One example method of testing an electrical device comprises transmitting a data pattern to a memory device of the electrical device by a controller of the electrical device to provide a written data pattern to the memory device, wherein the data pattern replicates a resonant frequency of at least a portion of the electrical device, reading the written data pattern from the memory device with the controller, and comparing the written data pattern to the data pattern.

Abstract: Methods and systems for time marking of media items at a platform using machine-learning are provided herein. An indication of a identified media item is provided as input to a machine-learning model and one or more outputs of the machine-learning model is obtained. The one or more obtained outputs comprise time marks identifying each of the plurality of content segments of the media item. Each of the plurality of content segments is associated with a segment start indicator for a timeline of the media item. A resulting duration is determined of a combination of the plurality of content segments for which the time marks were obtained from the one or more of outputs of the machine-learning model. Responsive to determining that the resulting duration is less than the duration of the media item, one or more further inputs is provided to the machine learning model.

Abstract: Methods and systems for predicting titles for contents segments of media items at a platform using machine-learning are provided herein. A media item is provided to users of a platform, the media item having a plurality of content segments comprising a first content segment and a second content segment preceding the first content segment in the media item. The first content segment and a title of the second content segment are provided as input to a machine-learning model trained to predict a title for the first content segment that is consistent with the title of the second content segment. One or more outputs of the machine-learning model are obtained which indicate the title for the first content segment. An indication of each content segment and a respective title of each content segment are provided for presentation to at least one user of the one or more users.

Abstract: A heart valve prosthesis delivery device can be modified in situ to facilitate retrieval of the device from a patient after delivery of a heart valve prosthesis. The device can include a nose cone that permits enclosures of the device to be drawn together in an aligned configuration, reducing the likelihood that the device will get caught on the prosthesis or vasculature as the device is retrieved from the patient.

Abstract: A method includes receiving a trajectory dataset including a plurality of geospatial points forming a point cloud and acquired along a trajectory wherein for each of the plurality of geospatial points there is a defined an x-coordinate, a y-coordinate and a z-coordinate and at least one mapping device orientation attribute, segmenting the trajectory dataset into a plurality of segments, determining at least one relative constraint for each of the plurality of segments and utilizing, for each of the plurality of segments, at least one of the determined relative constraints to determine a relative position of at least two of the plurality of segments.

Abstract: The invention relates to a device (1) having at least one fuel cell (2) and a DC/DC converter (3) assigned to the latter. A variable voltage generated in the fuel cell (2) is converted, by means of the DC/DC converter (3), into a DC voltage for a system (4) to be supplied. The DC/DC converter (3) is designed to capture internal characteristic variables of the fuel cell (2). Operating states of the fuel cell (2) are captured and/or controlled in dependence on these characteristic variables.

Abstract: Disclosed are a method and a device for manufacturing liquid hydrogen by offshore off-grid superconducting wind turbine. The method comprises the following steps: electrolyzing seawater to obtain hydrogen based on electric energy output by an offshore off-grid superconducting wind turbine generator, liquefying the hydrogen into prepared liquid hydrogen, and outputting a part of the liquid hydrogen as the refrigerant of the offshore off-grid superconducting wind turbine generator. The device comprises a liquid preparation platform, an offshore off-grid superconducting wind turbine generator, a seawater electrolysis unit, a hydrogen liquefaction unit and a liquid hydrogen storage unit, wherein the power ends of the seawater electrolysis unit and the hydrogen liquefaction unit are connected with the output end of the offshore off-grid superconducting wind turbine generator, and the hydrogen liquefaction unit is connected with the coolant input end of the offshore off-grid superconducting wind turbine generator.