Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.

Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.

Abstract: Lipid nanoparticles having improved properties are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent to primates for treatment of various indications is also described.

Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.

Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.

Abstract: Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells.

Abstract: A fluid detection apparatus and a fluid detection method are provided. The fluid detection apparatus includes a plurality of capacitive detection units and a sensing circuit. The capacitive detection units are sequentially arranged along a detection direction, wherein each of the capacitive detection units generates an impedance variation in response to the submergence of the fluid and accordingly generates a corresponding fluid detection signal. The sensing circuit is coupled to the capacitive detection units so as to receive the fluid detection signals and send a first status indication signal indicating a spread circumstance of the fluid along the detection direction according to the fluid detection signals.

Abstract: A fluid detection apparatus and a fluid detection method are provided. The fluid detection apparatus includes a plurality of capacitive detection units and a sensing circuit. The capacitive detection units are sequentially arranged along a detection direction, wherein each of the capacitive detection units generates an impedance variation in response to the submergence of the fluid and accordingly generates a corresponding fluid detection signal. The sensing circuit is coupled to the capacitive detection units so as to receive the fluid detection signals and send a first status indication signal indicating a spread circumstance of the fluid along the detection direction according to the fluid detection signals.

Abstract: A wireless communications device connected to a service network with a synchronized timing pattern therebetween is provided. In the wireless communications device, a wireless modem is configured to enable wireless signal transceiving from and to the service network in a non-sleep mode and disable wireless signal transceiving from and to the service network in a sleep mode. Also in the wireless communications device, a synchronization module is configured to initialize a first counter with a current time in the synchronized timing pattern in response to a first signal triggering the wireless modem to enter the sleep mode from the non-sleep mode, and enable counting of the first counter in a low-rate clock for the sleep mode. The synchronization module further provides the counted value of the first counter to the wireless modem to resynchronize with the service network in response to a second signal triggering the wireless modem to recover from the sleep mode to the non-sleep mode.

Abstract: A wireless communications device connected to a service network with a synchronized timing pattern therebetween is provided. In the wireless communications device, a wireless modem is configured to enable wireless signal transceiving from and to the service network in a non-sleep mode and disable wireless signal transceiving from and to the service network in a sleep mode. Also in the wireless communications device, a synchronization module is configured to initialize a first counter with a current time in the synchronized timing pattern in response to a first signal triggering the wireless modem to enter the sleep mode from the non-sleep mode, and enable counting of the first counter in a low-rate clock for the sleep mode. The synchronization module further provides the counted value of the first counter to the wireless modem to resynchronize with the service network in response to a second signal triggering the wireless modem to recover from the sleep mode to the non-sleep mode.

Abstract: The disclosure relates to an apparatus to improve the performance of system logging. The apparatus comprises a buffer storing a log, a log register comprising a bit, and a core unit. The core unit is coupled to the buffer and the log register to acquire and transmit the log to an external computer host when detecting that the bit is asserted.

Abstract: A nitride based semiconductor laser diode device comprising a selective growth mask with a grating structure is proposed. The island-like stacked epitaxial layers including the P-type cladding layer is formed from the selective growth mask upon the active layer of the semiconductor laser structure. This proposed structure can reduce the strain by the deformation due to the isolate structure. Thus, increase of thickness of the cladding layer and/or increase of composition difference can be achieved without crack existing in the island-like stacked epitaxial layers. The optical confinement can be effectively improved.

Abstract: A nitride based semiconductor laser diode device comprising a selective growth mask with a grating structure is proposed. The island-like stacked epitaxial layers including the P-type cladding layer is formed from the selective growth mask upon the active layer of the semiconductor laser structure. This proposed structure can reduce the strain by the deformation due to the isolate structure. Thus, increase of thickness of the cladding layer and/or increase of composition difference can be achieved without crack existing in the island-like stacked epitaxial layers. The optical confinement can be effectively improved.

Abstract: A nitride based semiconductor laser diode device comprising a selective growth mask with a grating structure is proposed. The island-like stacked epitaxial layers including the P-type cladding layer is formed from the selective growth mask upon the active layer of the semiconductor laser structure. This proposed structure can reduce the strain by the deformation due to the isolate structure. Thus, increase of thickness of the cladding layer and/or increase of composition difference can be achieved without crack existing in the island-like stacked epitaxial layers. The optical confinement can be effectively improved.

Abstract: A nitride based semiconductor laser diode device comprising a selective growth mask with a grating structure is proposed. The island-like stacked epitaxial layers including the P-type cladding layer is formed from the selective growth mask upon the active layer of the semiconductor laser structure. This proposed structure can reduce the strain by the deformation due to the isolate structure. Thus, increase of thickness of the cladding layer and/or increase of composition difference can be achieved without crack existing in the island-like stacked epitaxial layers. The optical confinement can be effectively improved.