Abstract: Embodiments of the present invention provide a motion tracking method for MR imaging, comprising: exciting an imaging volume of a detected object; shifting a frequency of an FID signal generated by the imaging volume relative to a center frequency as a position of the imaging volume changes; acquiring the FID signal and calculating a frequency shift of the acquired FID signal relative to the center frequency for multiple times; and obtaining a motion trajectory of the detected object in accordance with a change of the frequency shift as a function of time.

Abstract: Provided herein are high-throughput, high-quality methods of consecutive in situ hybridization for analysis of the genome and/or transcriptome in an individual cell with single-molecule sensitivity. In particular, provided herein are methods comprising visualizing individual genomic loci or transcripts as single detectable signals (e.g., fluorescent spots) which remain in place during consecutive hybridization. In each cycle of consecutive hybridization, detectably labeled probes hybridize to the probe used in the previous cycle, and also introduce the binding sites for the probe of the following cycle. Through consecutive cycles of probe hybridization, imaging, and signal removal, different genomic loci or RNA species can be identified by unique detectable signal profiles (e.g., fluorescent spots with unique color sequences). The number of varied color sequences increases exponentially with the number of hybridization cycles, which enables the genome or transcriptome-wide analysis.

Abstract: A lighting device having a side-emitting fiber bundle is provided. The fiber bundle is inserted in a sleeve that has an extension, which is effective as a light mixer.

Abstract: This invention provides a process for sequencing nucleic acids using 3? modified deoxynucleotide analogs or 3? modified deoxyinosine triphosphate analogs, and 3? modified dideoxynucleotide analogs having a detectable marker attached to a base thereof.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: Methods and apparatuses for processing MR signal are disclosed herein. An exemplary method comprises: when acquired K-space signals are amplified, assigning a first amplification gain to signals within a first signal region in the K space, and assigning a second amplification gain to signals within a second signal region in the K space.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.

Abstract: A system for the iterative detection of biological molecules includes a probe, and a fluorophore tethered to the probe with an azide-based linker. The linker is configured to be cleaved in the presence of tris(2-carboxyethyl)phosphine (TCEP), and the on/off ratio between a signal measured before treatment with TCEP and a signal measured after treatment with TCEP is at least about 20:1.

Abstract: An electronic device can include a HEMT including at least two channel layers. In an embodiment, a lower semiconductor layer overlies a lower channel layer, wherein the lower semiconductor layer has an aluminum content that is at least 10% of a total metal content of the lower semiconductor layer. An upper semiconductor layer overlies the upper channel layer, wherein the upper semiconductor layer has an aluminum content that is greater as compared to the lower semiconductor layer. In another embodiment, an electronic device can include stepped source and drain electrodes, so that lower contact resistance can be achieved. In a further embodiment, an absolute value of a difference between pinch-off or threshold voltages between different channel layers is greater than 1 V and allows current to be turned on or turned off for a channel layer without affecting another channel layer.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: An electronic device can include a lower channel layer, an upper channel layer overlying the lower channel layer and having an opening extending through the upper channel layer. The electronic device can further include an insulator within the opening; and a gate electrode extending into the opening, wherein the insulator is disposed between the gate electrode and the second channel layer. A double channel transistor can include the lower and upper channel layers and the gate electrode. In a further embodiment, a conductive member can be used to electrically short the channel layers near the gate electrode. In an embodiment, the transistor can be enhancement-mode transistor. A process can include forming the insulator such that it is in the form of a sidewall spacer or as an insulating layer along the sidewall and bottom of the opening through the upper channel layer.

Abstract: A solenoid switch for a vehicle starter is disclosed, which comprises a housing defining an axial direction; a cap carrying a pair of contact studs, the cap having a front end which is fixed in the housing; a solenoid core mounted in the housing in front of the cap; and an elastic element having a maximum (extreme) allowance compression in the axial direction, the elastic element being compressed between the cap and the solenoid core in the axial direction by an elastic pre-compression amount which is smaller than the maximum allowance compression; wherein the solenoid core is supported by the housing at its front side and is supported by the elastic element at its back side. A vehicle starter comprising such a solenoid switch is also disclosed. Axial bouncing of the cap can be reduced by the invention.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.

Abstract: An electronic device can include a HEMT including at least two channel layers. In an embodiment, a lower semiconductor layer overlies a lower channel layer, wherein the lower semiconductor layer has an aluminum content that is at least 10% of a total metal content of the lower semiconductor layer. An upper semiconductor layer overlies the upper channel layer, wherein the upper semiconductor layer has an aluminum content that is greater as compared to the lower semiconductor layer. In another embodiment, an electronic device can include stepped source and drain electrodes, so that lower contact resistance can be achieved. In a further embodiment, an absolute value of a difference between pinch-off or threshold voltages between different channel layers is greater than 1 V and allows current to be turned on or turned off for a channel layer without affecting another channel layer.

Abstract: The present invention provides an image identification method, a magnetic resonance imaging method and an imaging apparatus. Said imaging apparatus comprises: a scanning device configured to scan a target object to obtain projection images of the target object along different directions; a processing unit configured to process the obtained projection images to obtain posture feature information of the target object; a posture determining unit configured to determine a posture of the target object according to the obtained posture feature information. Therefore, the posture of the target object may be automatically recognized during the imaging, and thus the imaging operation is simplified, improving efficiency and reliability of the imaging operation.

Abstract: Techniques, systems and apparatus are described for magnetic resonance imaging by modifying the shape/thickness of an excitation/inversion slab. For instance, the inversion slab can be shaped as a wedge to improve temporal signal-to-noise ratio (tSNR) of arterial spin labeling (ASL) experiments by matching the temporal bolus width with the inter-pulse spacing in different feeding arteries. The shape/thickness of the excitation/inversion slab across the X-Y plane can be modified by modulating the movement of the “on-resonance” plane in space by the combination of conventional slice-selective (SS) adiabatic fast passage (AFP) and additional in-plane gradient pulses. Using this method, a computer can generate different shapes of the excitation/inversion slab.

Abstract: A lighting device having a side-emitting fiber bundle is provided. The fiber bundle is inserted in a sleeve that has an extension, which is effective as a light mixer.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: A system for the iterative detection of biological molecules includes a probe, and a fluorophore tethered to the probe with an azide-based linker. The linker is configured to be cleaved in the presence of tris(2-carboxyethyl)phosphine (TCEP), and the on/off ratio between a signal measured before treatment with TCEP and a signal measured after treatment with TCEP is at least about 20:1.

Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.