Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for treatment of IL-33 mediated disorders (e.g., ocular disorders such as AMD (e.g., geographic atrophy (GA)).

Abstract: Systems, methods, and computer-readable storage media providing highly scalable and fault tolerant notification systems are disclosed. Disclosed notification systems may be configured to: receive a plurality of notification requests including message content and recipient information, which may be allocated to at least one notification engine for processing. A notification engine may be configured to: generate a plurality of attempts corresponding to notification requests allocated for processing by the first notification engine and assign each generated attempt to a particular attempt queue. A plurality of connectors may be configured to: select a set of attempts for transmission from the plurality of attempt queues, transmit the set of attempts via at least one communication network. One or more databases may be provided to store status information associated with processing of notification requests by the first notification engine.

Abstract: Systems, methods, and computer-readable storage media for providing a notification system are disclosed. The notification system may be configured to select one or more notification requests from each of a plurality of notification request queues, and generate a plurality of attempts for each of the one or more selected notification requests. The attempts may be assigned to one of a first plurality of attempt queues, and flow control logic may be executed against the first plurality of attempt queues to dynamically select attempts for transmission from among the first plurality of attempt queues. Selected attempts are inserted into one of a second plurality of attempt queues, and a plurality of connectors may be configured to select attempts from the second plurality of attempts queues for transmission via a communication channel.