Abstract: A valve core assembly and a reversing valve with the valve core assembly. The valve core assembly comprises: a guide frame (10); and a sliding block (20), wherein the guide frame (10) is in drive connection with the sliding block (20), one side of the sliding block (20) is provided with a cavity, the other side of the sliding block (20) is provided with a blocking portion (30), and the blocking portion (30) is used to block an inlet passage. The technical solution can solve the problem in the related art that reversing failure of a reversing valve easily occurs.

Abstract: A system for managing, storing and providing shared digital content to a group of users in a multi-platform environment, comprising a cloud storage component configured to store digital content items that are shared by members in a user relationship defined group, and a cloud service component configured to provide one of the digital content items to a first platform for a first member of the user relationship defined group in a format suitable for the first platform and to a second platform for a second member of the user relationship defined group in a format suitable for the second platform, wherein the first platform and the second platform are different platforms.

Abstract: A method implemented by a multi-access edge computing (MEC) distributed controller includes receiving a MEC computing task request for execution of a service on MEC nodes controlled by the MEC distributed controller; obtaining mobile device geo-location information associated with the mobile device; determining an execution plan and a pool of MEC nodes, the execution plan and the pool of MEC nodes being for the execution of the service, the determining being in accordance with the mobile device geo-location information; scheduling the execution plan for the pool of MEC nodes; and deploying the scheduled execution plan.

Abstract: The present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA and its application in protein expression. Specifically, the present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA, recombinant expression vector, pre-circularized RNA, circular RNA, recombinant host cell, pharmaceutical composition and protein preparing method. The transcription product of the recombinant nucleic acid molecule in this present disclosure is a circular RNA which containing specific IRES element. IRES element can increase the protein expression level of circular RNA in eukaryotic cells, achieve efficient and persistent expression of protein. It has important application value in many fields like: Preparation of mRNA infectious disease vaccines, therapeutic mRNA tumor vaccines, mRNA-based dendritic cell tumor vaccines, mRNA-based gene therapy, mRNA-based chimeric antigen receptor T cell therapy, and protein supplement therapy.

Abstract: The disclosure belongs to the technical field of bioinformatics and bioengineering, and specifically, relates to a Levenshtein distance-based IRES screening method, a polynucleotide screened based on this method, a circular nucleic acid molecule including the polynucleotide, a cyclization precursor nucleic acid molecule, a recombinant nucleic acid molecule, a recombinant expression vector, a recombinant host cell, and use. In the disclosure, averages of Levenshtein distances between all sample sequences and to-be-predicted sequences are compared, to efficiently and accurately determine whether there is an IRES in the to-be-predicted sequence, which has advantages of high efficiency and an accurate screening result.

Abstract: The present disclosure belongs to the technical field of bio-medicine, particularly, the present disclosure relates to a tissue-specifically expressed circular RNA molecule, a cyclization precursor RNA molecule, a recombinant nucleic acid molecule, a recombinant expression vector, a recombinant host cell, a composition, a pharmaceutical preparation and application thereof in preparation of a drug for preventing or treating diseases, as well as a method for preventing or treating diseases. The circular RNA molecule provided by the present disclosure operably links a coding region to an expression regulatory element, realizing specific high expression of a target polypeptide in target cells or target tissues, and low expression of the target polypeptide in non-target cells or non-target tissues, and having high tissue expression specificity, thereby providing a safe and effective treatment strategy for clinical targeted therapy of diseases such as tumors.

Abstract: The present disclosure belongs to the field of biomedicine. Specifically, the present disclosure relates to a circular RNA molecule, a cyclization precursor RNA molecule, a recombinant nucleic acid molecule, a recombinant expression vector, a recombinant host cell, a composition and use thereof in targeted degradation of a protein of interest, as well as a method for preventing or treating a disease. The circular RNA molecule has good membrane permeability, is easily delivered into cells, and has high-efficiency in vivo protein targeted degradation activity. The circular RNA molecule of the present disclosure successfully achieves inhibition of tumor growth, which proves the in vivo protein degradation activity of bio-PROTACs for the first time, and provides a positive and effective treatment solution for the treatment of diseases such as tumor.

Abstract: The present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA and its application in protein expression. Specifically, the present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA, recombinant expression vector, pre-circularized RNA, circular RNA, recombinant host cell, pharmaceutical composition and protein preparing method. The transcription product of the recombinant nucleic acid molecule in this present disclosure is a circular RNA which containing specific IRES element. IRES element can increase the protein expression level of circular RNA in eukaryotic cells, achieve efficient and persistent expression of protein. It has important application value in many fields like: Preparation of mRNA infectious disease vaccines, therapeutic mRNA tumor vaccines, mRNA-based dendritic cell tumor vaccines, mRNA-based gene therapy, mRNA-based chimeric antigen receptor T cell therapy, and protein supplement therapy.

Abstract: The present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA and its application in protein expression. Specifically, the present disclosure relates to a recombinant nucleic acid molecule of the transcriptional circular RNA, recombinant expression vector, pre-circularized RNA, circular RNA, recombinant host cell, pharmaceutical composition and protein preparing method. The transcription product of the recombinant nucleic acid molecule in this present disclosure is a circular RNA which containing specific IRES element. IRES element can increase the protein expression level of circular RNA in eukaryotic cells, achieve efficient and persistent expression of protein. It has important application value in many fields like: Preparation of mRNA infectious disease vaccines, therapeutic mRNA tumor vaccines, mRNA-based dendritic cell tumor vaccines, mRNA-based gene therapy, mRNA-based chimeric antigen receptor T cell therapy, and protein supplement therapy.

Abstract: A first aspect relates to a computer-implemented method for performing model compression. The method includes compressing a machine learning (ML) network model comprising a multiple layer structure to produce a compressed ML network model. The compressed ML network model maintains the multiple layer structure of the ML network model. The method generates a model file for the compressed ML network model. The model file includes the compressed ML network model and decoding information for enabling the ML network model to be decompressed and executed layer-by-layer.

Abstract: A display luminance adjustment method and an electronic device, where the display luminance adjustment method includes obtaining an initial luminance value of a display screen, obtaining an ambient light signal, determining a target luminance value of the display screen based on the ambient light signal, obtaining a target pixel value of a to-be-displayed image based on the initial luminance value, the target luminance value, and a current pixel value of the to-be-displayed image, and presenting the to-be-displayed image on the display screen based on the target pixel value of the to-be-displayed image.

Abstract: A system for managing, storing and providing shared digital content to a group of users in a multi-platform environment, comprising a cloud storage component configured to store digital content items that are shared by members in a user relationship defined group, and a cloud service component configured to provide one of the digital content items to a first platform for a first member of the user relationship defined group in a format suitable for the first platform and to a second platform for a second member of the user relationship defined group in a format suitable for the second platform, wherein the first platform and the second platform are different platforms.

Abstract: A system for managing, storing and providing shared digital content to a group of users in a multi-platform environment, comprising a cloud storage component configured to store digital content items that are shared by members in a user relationship defined group, and a cloud service component configured to provide one of the digital content items to a first platform for a first member of the user relationship defined group in a format suitable for the first platform and to a second platform for a second member of the user relationship defined group in a format suitable for the second platform, wherein the first platform and the second platform are different platforms.

Abstract: Operation of an autonomous vehicle is modified based on the driving style preferences of a passenger. A machine learning module for a motion planner of the autonomous vehicle accepts input relating to driving style of the autonomous vehicle including data representing autonomous vehicle speed, acceleration, braking, or steering during operation. The passenger also provides feedback relating to the vehicle's driving style during operation, and the passenger feedback is used to train the machine learning module to create a personal driving style decision-making model for the passenger that controls operation of the autonomous vehicle. A personal driving style preference profile for the passenger also may be obtained by collecting motion sensor data relating to driving habits of the passenger when the passenger is a driver. The driving style preference profile is used by the motion planner to modify operation of the autonomous vehicle in accordance with the driving style preference profile.

Abstract: A method implemented in a network element (NE) configured to operate as an Ensemble Information Broker (EIB) within a distributed data and energy storage internet architecture comprising collecting energy data indicating a flow of energy, an amount of energy consumed and generated by devices; collecting human presence data; collecting human activity data; predicting future energy consumption requirements and generation by employing prediction algorithms and analyzing the collected data; generating a set of control commands based on the predicted future energy consumption requirements and energy generation as applied to a cost function; transmitting the set of control commands to the corresponding devices; transmitting a broadcast message to determine an external NE to establish as a friend connection based on a user preference; transmitting a request to establish a friend connection with the determined NE; and transmitting the human presence data to the external NE when the friend connection is established.

Abstract: The present disclosure relates to a storage and transfer apparatus for mass transfer of a plurality of data discs to trays of a plurality stacked disc drives. The storage and transfer apparatus may store a plurality of discs with the disc hold pins retracted and the telescopic sections collapsed over each other. In such a configuration, the stored discs may lie in contact with each other. The storage and transfer apparatus may transfer the plurality of discs to the trays of the plurality of stacked disc drives with the discs holding pins extended and the telescopic sections extended relative to each other.

Abstract: A computer-implemented method of controlling vehicle traffic through an intersection comprising: receiving a request, by one or more processors of a traffic flow controller and from each of a plurality of vehicles, to use the intersection; allocating, by the one or more processors and to a first subset of the plurality of vehicles, a first ticket to use the intersection; allocating, by the one or more processors and to a second subset of the plurality of vehicles, a second ticket to use the intersection; authorizing, by the one or more processors, the first subset of the plurality of vehicles to use the intersection; determining, by the one or more processors, that all vehicles of the first subset of the plurality of vehicles have cleared the intersection; and authorizing, by the one or more processors, the second subset of the plurality of vehicles to use the intersection.

Abstract: An embodiment method for managing connections on a communications network having an optical network portion includes receiving a request for a first connection at a controller in signal communication with one or more reconfigurable optical add-drop multiplexers (ROADMs) controlling an optical network portion of a communications network, wherein the controller is connected to the communications network. The controller determines a route on the communications network for the first connection according to conditions of the communications network, with the route comprising one or more first links of the optical network. The controller determines one or more first ROADMs controlling the one or more first links and sends commands from the controller to the one or more first ROADMs to allocate bandwidth on the one or more first links.

Abstract: An apparatus comprising a processor configured to obtain estimated processing requirements, estimated memory requirements, estimated storage requirements, and estimated network communication requirements for a plurality of data center (DC) tenants; determine a Minimum Resource Schedulable Unit (MRSU) for the tenants, the determined MRSU comprising a dynamically allocatable group of processor resources, processing memory resources, storage resources, and network resources comprised in at least one of a plurality of DC servers, wherein the MRSU is determined such that each DC tenant's estimated processing requirements, estimated memory requirements, estimated storage requirements, and estimated network communications requirements are met by allocation of a corresponding integer value of MRSUs; and allocate the corresponding integer value of MRSUs to each DC tenant as an MRSU allocation; and a transmitter coupled to the processor and configured to transmit the MRSU allocation to the DC servers for allocation to

Abstract: A computer-implemented method of controlling vehicle traffic through an intersection comprising: receiving a request, by one or more processors of a traffic flow controller and from each of a plurality of vehicles, to use the intersection; allocating, by the one or more processors and to a first subset of the plurality of vehicles, a first ticket to use the intersection; allocating, by the one or more processors and to a second subset of the plurality of vehicles, a second ticket to use the intersection; authorizing, by the one or more processors, the first subset of the plurality of vehicles to use the intersection; determining, by the one or more processors, that all vehicles of the first subset of the plurality of vehicles have cleared the intersection; and authorizing, by the one or more processors, the second subset of the plurality of vehicles to use the intersection.