Abstract: A high temperature and high salinity-resistant complementarily rigid-flexible plugging agent, a method for preparing the same, and a water-based drilling fluid and a use thereof.

Abstract: A method includes: obtaining a total data length of an information bit; and obtaining C code blocks based on the total data length of the information bit and a preset first code rate. The C code blocks correspond to one or more code lengths, where the one or more code lengths meet a form of a positive integer power of 2, and where C is a positive integer.

Abstract: Transcription factors (TFs) represent a major class of therapeutic targets for the treatment of human diseases including cancer. Although the biological function and even crystal structure of many TFs have been clearly elucidated, there is still no viable approach to target the majority of TFs, thus rendering them undruggable for decades. PROTACs (PROteolysis TArgeting Chimeras) have emerged as a powerful tool for the pharmaceutical development since the effect of PROTACs largely relies on engineered protein-protein interaction to aid the degradation of targets by the ubiquitin-proteasome system (UPS). The present disclosure provides a DNA-PROTAC platform for targeted degraders of individual TFs of interest. These DNA based Transcription Factor targetting PROTACS (or “TF-PROTACS”) may provide specificity to TF degradation based on the conserved DNA-binding motifs of respective TFs.

Abstract: A method for cleaning semiconductor substrate without damaging patterned structure on the semiconductor substrate using ultra/mega sonic device comprises applying liquid into a space between a substrate and an ultra/mega sonic device; setting an ultra/mega sonic power supply at frequency f1 and power P1 to drive the ultra/mega sonic device; before bubble cavitation in the liquid damaging patterned structure on the substrate, setting the ultra/mega sonic power supply at zero output; after temperature inside bubble cooling down to a set temperature, setting the ultra/mega sonic power supply at frequency f1 and power P1 again; detecting power on time at power P1 and frequency f1 and power off time separately or detecting amplitude of each waveform output by the ultra/mega sonic power supply; comparing the detected power on time with a preset time ?1, or comparing the detected power off time with a preset time ?2, or comparing detected amplitude of each waveform with a preset value, if the detected power on time

Abstract: A sending device performs first encoding on at least one first code block, to obtain at least one first code word, where each first code block includes a first information block and a first check block for checking the first information block. The sending device performs at least one type of second encoding on at least one second code block, to obtain at least one second code word, where the at least one second code block includes a second check block for checking a portion of information in the at least one second code block, and a code length of the first code word is greater than a code length of the second code word. The sending device generates and sends a data packet that includes the at least one first code word and the at least one second code word.

Abstract: The present disclosure discloses a high-temperature fast-curing starch-based adhesive for particleboards and a preparation method thereof, belonging to the technical field of adhesive preparation. The low viscosity of the starch-based adhesive is ensured by selecting a crosslinking monomer which does not self-crosslink in a reaction process in the present disclosure, and a binary crosslinking agent matched with the crosslinking monomer is added before use to be quickly crosslinked with the crosslinking monomer at high temperature so as to ensure better thermosetting property and water resistance as well as faster curing speed of the starch-based adhesive at the same time, which meets the requirements of the particleboards for the adhesive, solves the problem of long curing time of the existing starch-based adhesives at high temperatures, further shortens the curing time of the starch-based adhesives to about 60 s, and improves the production efficiency of the particleboards.

Abstract: Disclosed are a display panel and a driving method therefor, and a display device. Two adjacent rows of sub-pixels are taken as a row group, and the row group is provided with a first sub row group and a second sub row group that are arranged in a column direction; a gate electrode of a first transistor in the first sub row group is electrically connected to a first gate line; a gate electrode of a second transistor in the second sub row group is electrically connected to a second gate line; two adjacent sub-pixels in the column direction share one third transistor, and a gate electrode of the third transistor in the row group is electrically connected to a third gate line; and the first transistor and the second transistor in one column of sub-pixels are electrically connected to a data line by means of the shared third transistor.

Abstract: A self-calibration detection device and a temperature demodulation method oriented to a fiber Raman temperature sensing system. The self-calibration detection device comprises a fiber Raman thermodetector, thermostatic baths, a multi-mode sensing fiber, and a multi-mode reflector. The fiber Raman thermodetector comprises a pulsed laser whose output end is connected to the input end of a WDM. Two output ends of the WDM are respectively connected to input ends of a first and second APDs. Output ends of the first and second APDs are respectively connected to input ends of a first and second LNAs. Output ends of the first and second LNAs are connected to the input end of a data acquisition card whose output end is connected with the input end of a computer. The temperature demodulation method can solve the problems of low temperature measuring accuracy, lower temperature measurement stability and low temperature measurement efficiency.

Abstract: Provided is a display substrate. The display substrate includes: a base substrate including a display region and a non-display region surrounding the display region; a gate drive circuit disposed in the non-display region; a plurality of first signal lines disposed in the peripheral region and connected to the gate drive circuit; and a plurality of second signal lines disposed in the non-display region and connected to the gate drive circuit; wherein each of the first signal line and the second signal line is configured to supply a signal to the gate drive circuit, and a frequency of the signal supplied by the first signal line is lower than a frequency of the signal supplied by the second signal line.

Abstract: The invention relates to a hair care composition comprising a) a cationic surfactant selected from stearamidopropyl dimethylamine, behentrimonium chloride, stearyl trimethyl ammonium chloride or mixtures thereof; b) from 15 to 30% by weight of glycerin; and c) from 0.1 to 2.0% by weight of fatty alcohol based on the total weight of the composition.

Abstract: A system for controlling damages in cleaning a semiconductor wafer comprising features of patterned structures, the system comprising: a wafer holder for temporary restraining a semiconductor wafer during a cleaning process; an inlet for delivering a cleaning liquid over a surface of the semiconductor wafer; a sonic generator configured to alternately operate at a first frequency and a first power level for a first predetermined period of time and at a second frequency and a second power level for a second predetermined period of time, to impart sonic energy to the cleaning liquid, the first predetermined period of time and the second predetermined period of time consecutively following one another; and a controller programmed to provide the cleaning parameters, wherein at least one of the cleaning parameters is determined such that a percentage of damaged features as a result of the imparting sonic energy is lower than a predetermined threshold.

Abstract: Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

Abstract: The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.

Abstract: An apparatus for analyzing a plant specimen is disclosed which includes a housing assembly adapted to be in i) an open configuration adapted to receive a plant specimen, and ii) a closed configuration wherein ambient light is controlled therein, a light source disposed in or coupled to the housing assembly, the light source adapted to shine light onto or through the plant specimen when the housing assembly is in the closed configuration, and a camera assembly coupled to the housing assembly, the camera assembly having an image sensor adapted to receive light from the plant specimen in i) a transmittance mode where light transmits through the plant specimen, or ii) a reflectance mode where light is reflected from the plant specimen, the image sensor adapted to thereby capture hyperspectral images of the plant specimen.

Abstract: Disclosed are phenothiazine compounds which reduce Abeta toxicity in vivo, reduce microglial inflammation as indicated by secretion of TNF-alpha, reduce intracerebral hemorrhage in vivo toxicity as indicated by preserved motor and cognitive function, and SARS-CoV-2 replication. Also disclosed are methods of use thereof for the treatment of disease in a subject in need thereof.

Abstract: A wireless data telemetry system for use in a drilling system can include a drill head wireless transmitter and at least one data link transceiver. The drill head wireless transmitter can be in a drill head of the drilling system, the drill head wireless transmitter configured to generate and transmit one or more data signals associated with a drilling process. The at least one data link transceiver can be wirelessly coupled to at least one of the drill head wireless transmitter or another data link transceiver, with the drill head wireless transmitter and the at least one data link transceiver configured to be physically coupled within a drill string and spaced apart from one another. The drill head wireless transmitter and the at least one data link transceiver together configured to wirelessly communicate the one or more data signals beyond a transmission range of the drill head wireless transmitter.

Abstract: Disclosed are Eleven-Nineteen Leukemia (ENL) degradation/disruption compounds including a ENL ligand, a degradation/disruption tag and a linker, and methods for use of such compounds in the treatment of ENL-mediated diseases.

Abstract: The present invention provides a drive module for a GaN transistor, including: a first pull-down transistor and a gate ringing and overshoot suppression unit, where the gate ringing and overshoot suppression unit and a first end of the first pull-down transistor are directly or indirectly connected to a gate of the GaN transistor, the gate ringing and overshoot suppression unit is connected between a second end of the first pull-down transistor and the ground; the gate ringing and overshoot suppression unit is configured to: when a gate voltage of the GaN transistor drops, control the release of a gate charge of the GaN transistor with a first impedance if the gate voltage is higher than a specified threshold; and control the release of the gate charge of the GaN transistor with a second impedance if the gate voltage is less than the specified threshold, where the first impedance is less than the second impedance.

Abstract: PROTACs (PROteolysis TArgeting Chimeras) are an emerging class of promising therapeutic modalities that degrade intracellular protein targets by hijacking the cellular ubiquitin-proteasome system. However, potential toxicity of PROTACs in normal cells due to off-tissue on-target degradation effect limits their clinical applications. Precise control of PROTAC's on-target degradation activity in a tissue selective manner could minimize potential toxicity/side-effects. To this end, we developed a cancer cell selective delivery strategy for PROTACs by conjugating a folate group to ubqiquitin recruitment moiety to achieve targeted degradation of proteins of interest (POIs) in cancer cells versus normal cells. We show that our folate-PROTACs, including BRD PROTAC (Folate-ARV-771), MEK PROTAC (Folate-MS432) and ALK PROTAC (Folate-MS99, Folate-S2-MS4048) are capable of degrading BRDs, MEKs and ALK, respectively, in a folate receptor-dependent manner.

Abstract: A portable apparatus for analyzing a plant specimen. A housing assembly defines a sensing volume and controls entry of ambient light into the sensing volume when the housing is closed. A specimen support positions a plant specimen within the sensing volume whereby light emitted from at least one light emitter is incident upon the plant specimen. An image sensor senses light from the at least one light emitter that has been incident on the plant specimen. A processor analyzes data obtained from the light sensor to assess one or more properties of the plant specimen. There may be more than one light emitter, e.g., a halogen lamp and LED array, and the apparatus may acquire images under more than one lighting condition. The apparatus may include a mechanism for moving the plant specimen relative to the optical path to take images at multiple regions of interest on the specimen.