Abstract: Disclosed are a glass ceramic composition, a preparation method and application thereof. The glass ceramic composition according to the present application includes: 58% to 72% of SiO2; 0% to 4% of Al2O3; 0% to 5% of Na2O; 3% to 8% of K2O; 8% to 17% of Li2O; 2.5% to 5% of P2O5, 0% to 2% of MgO, 0% to 2.5% of B2O3; 0% to 5% of ZnO; and 0% to 3% of ZrO2. It is possible to prepare such lithium metasilicate glass ceramic with a crystal phase of lithium metasilicate, a crystallinity of greater than 50%, a grain size of 30 nm to 60 nm and a hardness of 500 kgf/mm2 to 590 kgf/mm2. The composition does not require an introduction of a high proportion of zirconia content, and can be ground to a thickness of 0.2 mm without edge collapse.

Abstract: The present invention belongs to the medical field, and relates to novel ?-lactamase inhibitors, for the treatment of bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I): or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: Methods, systems, and devices for power backoff techniques for modulation schemes are described. A user equipment (UE) may receive an indication of a constellation distribution parameter and a modulation scheme to be used by the UE for an uplink message on an uplink channel. The UE may determine an uplink transmission power based at least in part on the indicated constellation distribution parameter and the indicated modulation scheme. The UE may transmit the uplink message using the indicated modulation scheme according to the determined uplink transmission power. In some examples, the UE may transmit a report indicating a power headroom parameter and an output power parameter based at least in part on the constellation distribution parameter.

Abstract: Transcription factors (TFs) represent a major class of therapeutic targets for the treatment of human diseases including cancer. Although the biological function and even crystal structure of many TFs have been clearly elucidated, there is still no viable approach to target the majority of TFs, thus rendering them undruggable for decades. PROTACs (PROteolysis TArgeting Chimeras) have emerged as a powerful tool for the pharmaceutical development since the effect of PROTACs largely relies on engineered protein-protein interaction to aid the degradation of targets by the ubiquitin-proteasome system (UPS). The present disclosure provides a DNA-PROTAC platform for targeted degraders of individual TFs of interest. These DNA based Transcription Factor targetting PROTACS (or “TF-PROTACS”) may provide specificity to TF degradation based on the conserved DNA-binding motifs of respective TFs.

Abstract: Disclosed are a glass ceramic material, a preparation method thereof, and a denture. The glass ceramic material includes the following components by mass percentage: 58% to 72% of SiO2, 0% to 4% of Al2O3, 0% to 5% of Na2O, 3% to 8% of K2O, 8% to 17% of Li2O, 2.5% to 5% of P2O5, 0% to 2% of MgO, 0% to 2.5% of B2O3, 0% to 5% of ZnO and 0% to 3% of ZrO2. In the present application, by optimizing the composition and ratio of the glass ceramic material, and combining with a matching process system, it is possible to control the formation of lithium disilicate while the crystallinity of lithium metasilicate glass ceramic can be improved without an introduction of a high ratio of zirconia content, thereby improving the grinding performance of the glass ceramic. The present application is applicable to the field of material technology.

Abstract: Introduced here is at least one technique to better estimate interference at a receiver. The technique includes receiving a plurality of reference signals, which each have information indicative of noise. Thus, the technique further includes, for each reference signal, determining a noise estimation and determining a distance metric and log-likelihood ratio (LLR) of the noise estimation. Once the distance metric and LLR of each reference signal is determined, the receiver can determine a final LLR based on the distance metric and LLR of each reference signal. In this manner, a final LLR is determined. This technique can be applied by any device operating on MIMO technology.

Abstract: Example methods and apparatus for transmitting ACK/NACK information for data are disclosed. One method includes sending a data packet from a base station to a user equipment. A control signaling is transmitted from the base station to the user equipment and is used to indicate a subframe to be used by the user equipment to send ACK/NACK information corresponding to the data packet.

Abstract: A touch substrate manufacturing method, for manufacturing a target touch substrate to be assembled with a display substrate, is provided. A size of an active display region of the display substrate is a first preset size. The method includes: providing a touch substrate to be processed having a second preset size, the second preset size being greater than the first preset size; and cutting, in at least one cutting direction, the touch substrate to be processed to obtain the target touch substrate, the cutting direction being parallel to an extending direction of a touch channel on the touch substrate to be processed. A manufacturing method for touch module, a touch substrate and a touch module are also provided.

Abstract: The disclosure relates to the field of electronic materials, and in particular to a composite film of fluorinated polybenzoxazole (6FPBO) and triple-shelled mesoporous silica hollow spheres, and to its preparation and use. The composite film comprises fluorinated polybenzoxazole as a matrix and amino-functionalized triple-shelled mesoporous silica hollow spheres which are dispersed in the fluorinated polybenzoxazole matrix. A mass ratio of (amino-functionalized triple-shelled mesoporous silica hollow spheres)/(fluorinated polybenzoxazole) is 1/100 to 5/100. The composite film has excellent thermal stability and a lower dielectric constant.

Abstract: An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.

Abstract: The present application discloses a class of guaianolide sesquiterpene lactone derivatives and pharmaceutical use thereof. The guaianolide sesquiterpene lactone derivative or a pharmaceutically acceptable salt thereof is shown as general formula I. In the present application, a class of novel guaianolide sesquiterpene lactone derivatives are found by structural optimization with abundant natural ingredients such as parthenolide and dehydrocostus lactone as raw materials, which derivatives have good inhibitory activity on the activation of the NLRP3 inflammasome, and the chemical stability, water solubility and oral bioavailability of which are significantly improved, and it is verified by experiments that the derivatives have inhibitory effects on the activity of the NLRP3 inflammasome and have potential pharmaceutical applications.

Abstract: A GAN training method, a machine learning system, and a communication apparatus are provided, which relate to the field of communication technologies and AI. The machine learning system includes a first device and a second device, where a first GAN runs on the first device, a second GAN runs on the second device, the first GAN includes a first generator and a first discriminator, and the second GAN includes a second generator and a second discriminator.

Abstract: Embodiments of this disclosure provide a communication method and device, a storage medium, and a program product. According to the communication method of this disclosure, a physical layer protocol data unit (PPDU) is transmitted or received based on a tone plan of a first bandwidth. The tone plan includes a physical resource unit (PRU), and the PRU includes discrete subcarriers. According to embodiments of this disclosure, an original nominal RU is processed to obtain a PRU including discrete subcarriers. Discretized subcarriers of the PRU may be evenly distributed on a larger bandwidth without changing subcarrier division of the original nominal RU. When it is ensured that a large PAPR is not generated in data transmission due to discrete subcarriers, a transmit end can perform communication at a high transmit power.

Abstract: A method and/or a communications apparatus controls a monitoring of a physical downlink control channel. The method includes: receiving, by a terminal device, a first message sent by a network device, where the first message includes M sleep time sets, and the sleep time is used to indicate a time length in which monitoring the PDCCH is stopped; receiving, by the terminal device, a second message sent by the network device, where the second message includes sleep time indication information, the sleep time indication information is used to indicate a target sleep time index, and the target sleep time index is an index in the M sleep time sets; and stopping, by the terminal device, monitoring the PDCCH in a target time period.

Abstract: A cooling system includes a housing including a base portion with sides and a bottom surface that define a cavity and a cover portion to enclose the base portion and including cooling members attached thereto. A shield is arranged in the cavity. A vertical member is arranged below the shield to define a first fluid chamber between one side of the vertical member and one side of the base portion and a second fluid chamber between an opposite side of the vertical member and another side of the base portion. The electronic components are arranged in the second fluid chamber. Cooling fluid is arranged in the cavity and has a fluid level below at least a portion of the shield. The housing is mounted at an inclined angle relative to horizontal or the housing is mounted parallel to horizontal and the shield is mounted at the inclined angle.

Abstract: Disclosed is a copper-niobium alloy for a medical biopsy puncture needle. A needle core and/or needle tube of the puncture needle are/is made of the copper-niobium alloy. The copper-chromium alloy includes the following components by mass: 5?Nb?15 and the balance of Cu. A copper alloy with designed components is obtained by combining a diamagnetic material Cu with paramagnetic Nb, and compared with existing medical stainless steel and titanium alloy, the copper alloy has greatly reduced magnetic susceptibility, and specifically, the artifact area and volume are also significantly reduced. In addition, the blank of use of the copper alloy in medical biopsy paracentesis is filled.

Abstract: A rapid demagnetization method based on characteristics of magnetic media. In the method, basic information is obtained by a recognition module of magnetic media by means of multi-source sensing collaboration. The magnetic medium is identified by using a data processing technology and a magnetic medium identification algorithm, and then the characteristic information is extracted. Optimized set values of demagnetization parameters are obtained by a demagnetization parameter optimizing and setting module based on a demagnetization optimizing model. Demagnetization parameter set values are tracked by a closed-loop control module of a demagnetization magnetic field in combination with domain expert knowledge by using a closed-loop control mechanism integrated with a magnetic field control algorithm, a charging-discharging device, a magnetic field generating device, a magnetic field sensor and an environmental sensor, completing the rapid demagnetization of the magnetic medium.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: Methods, systems, and devices for wireless communications are described. In some systems, a wireless device may In use non-uniformly distributed bits for amplitude mapping and uniformly distributed bits for sign mapping to support probabilistic constellation shaping (PCS) for transmission of a message. To provide a coding gain with one or more retransmissions of the message, the device may configure redundancy versions based on the non-uniform distribution of one or more symbols. In some examples, the device may include the same set of non-uniformly distributed systematic bits or at least a portion of non-uniformly distributed systematic bits in each redundancy version of the message. Additionally or alternatively, the device may use multiple modulation and coding scheme (MCS) values to modulate one or more of the redundancy versions, where a first MCS value is used to modulate non-uniformly distributed symbols and a second MCS value is used to modulate uniformly distributed symbols.