Abstract: The present invention provides an application of a small-molecule compound in preparation of an antitumor drug. A series of small-molecule drugs with high brain tumor growth activity inhibitory properties are obtained, are docked to pharmacodynamic analysis of the small-molecule drugs, and do not need to be transferred to other testing platforms.

Abstract: Disclosed is a membrane-type metalloprotease inhibitory protein T1Pr?TACE and use thereof, which can be used for preparing drugs targeting MT1-MMP or TACE endonuclease. Also disclosed are an antitumor pharmaceutical composition comprising BHK-21 cells and an artificial basal membrane which expresses T1Pr?TACE protein.

Abstract: The present invention relates to the technical field of biochemistry. Disclosed are a mutant enzyme, the use thereof and a process for preparing a tripeptide by using an enzymatic method. The mutant enzyme comprises: glycine and L-histidine ligase GHS, and tripeptide ligase HKS; or a fusion enzyme of the two. Glycine and L-histidine ligase activity is achieved by means of modifying an Lal enzyme, so as to obtain the GHS enzyme; and the ability for synthesizing dipeptide glycine-L-histidine and L-lysine is achieved by means of using a gshB enzyme, so as to obtain the HKS enzyme. On this basis, the GHS enzyme is further fused with the HKS enzyme by means of using a polypeptide chain, and then a bifunctional enzyme GHKS that links glycine, L-histidine and L-lysine in one step can be constructed, so that a tripeptide is conveniently prepared with a high yield.

Abstract: A polymer having a dispersing function, a preparation method therefor and use thereof as a cement dispersant are provided. The polymer has a structural unit (a), a structural unit (b) and a structural unit (c). The structural unit (a) is provided by an unsaturated polyether, the structural unit (b) is provided by an unsaturated acid and/or a salt thereof and/or an anhydride thereof, and the structural unit (c) is provided by a silane and/or siloxane having a polymerizable group and no less than five carbon atoms. The molar ratio of the structural unit (a), the structural unit (b) and the structural unit (c) is 1:(1-20):(0.01-0.5); and the polymer has a weight average molecular weight of 20,000-90,000 g/mol.

Abstract: The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: Methods, apparatus, computer program products for tracking sensitive data are provided. A method for tracking sensitive data comprises identifying, by one or more processing units, for a type of sensitive data, at least one key interface that carries the type of sensitive data and recording the at least one key interface. The method further comprises generating, by one or more processing units, for the type of sensitive data, for each type of sensitive data, a series of service nodes based on the at least one key interface, and monitoring, by one or more processing units, for the type of sensitive data, corresponding data traffic flowing through corresponding series of service nodes, based on the identified at least one key interface.

Abstract: A slider includes: a first coupling section; a second coupling section; and an impedance conversion line, which is connected between the first coupling section and the second coupling section, and includes a series portion and a parallel portion connected in series, wherein the series portion includes only one first connection line, and the parallel portion includes at least two second connection lines connected in parallel.

Abstract: A projection apparatus and a keystone correction method thereof are provided. The projection apparatus includes a display processing circuit including an image processing circuit, a first keystone correction circuit, a rotation circuit, a second keystone correction circuit, and a video output circuit. The first keystone correction circuit performs first keystone correction processing on a processed image frame based on horizontal scaling processing to obtain a first corrected image frame. The rotation circuit performs rotation processing on the first corrected image frame to write a rotated image frame into a memory. The second keystone correction circuit reads the rotated image frame from the memory and performs second keystone correction processing on the rotated image frame based on the horizontal scaling processing to obtain a second corrected image frame. The video output circuit transmits the second corrected image frame to a projection module through a data transmission interface.

Abstract: Provided is a pixel driving circuit. The pixel driving circuit includes a reset unit, a storage unit, an initialization unit, a drive unit, a threshold compensation unit, and a data write unit. A first terminal of the reset unit is configured to input the signal output by a reset power supply. A second terminal of the reset unit is connected to the control terminal of the drive unit and configured to provide the reset power supply for the control terminal of the drive unit during a power-on period. During the power-on period of the pixel driving circuit, the reset unit provides the reset power supply for the drive unit and performs reset control on the drive unit, so that the drive unit is prevented from being abnormally turned on during a power-on stage, thereby avoiding a screen flicker phenomenon.

Abstract: A child safety seat (100) is provided and includes a base (10), a seat body (20) installed on the base (10), a locking device (40), a locked portion (11) and an operating component (30) movably linked to the locking device (40). The seat body (20) is switchable between a forward-facing orientation and a rearward-facing orientation. The locking device (40) and the locked portion (11) are respectively disposed on one and another one of the seat body (20) and the base (10). The locking device (40) engages with the locked portion (11) when the seat body (20) is located in the forward-facing orientation or the rearward-facing orientation. The operating component (30) drives the locking device (40) to disengage from the locked portion (11) for allowing the seat body (20) to switch between the forward-facing orientation and the rearward-facing orientation.

Abstract: Training a predict model with network traffic and data change messages generated by an existing web application running in a production environment. The predict model being is trained to predict data changes resulted from API calls embodied in network traffic. A stream of network traffic of the existing web application is replayed with an upgraded version of the existing web application to generate real data changes. The stream of network traffic is applied to the predict model to generate predicted data change messages. The predicted data change messages are comparing with real data change messages representing the real data changes. One or more existing APIs is identified as being possibly functionally degraded based on any inconsistency of the predicted data change messages with the real data change messages.

Abstract: Base station antennas include an externally accessible active antenna module releasably coupled to a recessed segment that is over a chamber in the base station antenna and that is longitudinally and laterally extending along and across a rear of a base station antenna housing. The base station antenna housing has a passive antenna assembly that cooperates with the active antenna module.

Abstract: A communication unit. The communication unit has an electromagnetic transmitter and/or receiver device and a fastening device for the electromagnetic transmitter and/or receiver device for fastening to a component, preferably to a drive unit and/or a frame, of a vehicle, preferably of a single-track vehicle such as an electric bicycle, including an in particular flat, essentially rectangular carrier, especially having two essentially oppositely situated sides on which the transmitter and/or receiver device is situated, at least a first holding element, the first holding element being designed to fasten the carrier to the component, the first holding element being made of metal, and the first holding element covering at least 50% of an in particular essentially rectangular side of the carrier that faces the component in a fastened state of the carrier.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Abstract: A method is performed at a backend server. The server receives a to-be-processed interaction message from a user interface of a social network platform. The server performs intention classification on the to-be-processed interaction message, to obtain an intention classification result of the to-be-processed interaction message. The server performs semantic analysis on the to-be-processed interaction message when the intention classification result comprises a mini program intention, to determine a message keyword of the to-be-processed interaction message. The server determines a program identifier of a target mini program corresponding to the to-be-processed interaction message according to the message keyword. The server transmits a message processing result based on the program identifier of the target mini program.

Abstract: A SAW sensor is optimized for detection of refrigerant leakage in a refrigerant system or other gases, vapors, explosives or chemicals of interest. The SAW sensor includes a piezoelectric substrate; an interdigitated transducer deposited on the piezoelectric substrate, the interdigitated transducer having an input portion that receives input surface acoustic waves and an output portion that emits output surface acoustic waves; and a refrigerant sensor film located between the input portion and the output portion of the interdigitated transducer, the refrigerant sensor film including a sorbent material that is selected for preferential adsorption of a target refrigerant over atmospheric gases. Adsorption of the target refrigerant by the sorbent material results in a frequency shift of a frequency of the output surface acoustic waves relative to a frequency of the input surface acoustic waves.

Abstract: The present disclosure provides a method for object detection and recognition based on a neural network. The method includes: adding a detection layer following three detection layers of an existing YOLOv5 network model, to construct a new YOLOv5 network model; then, training the new YOLOv5 network model by considering an overlapping area between a predicted box and a ground truth box, a center-to-center distance between the two boxes, and an aspect ratio of the two boxes; and finally, inputting a to-be-detected image into the trained new YOLOv5 network model, outputting a predicted box of an object and probability values corresponding to a class to which the object belongs, and setting a class corresponding to a maximum probability value as a predicted class of the object in the to-be-detected image. This method can quickly and effectively detect multiple classes of objects. Especially, a detection effect for small objects is more ideal.

Abstract: The present disclosure provides an intralocular-lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

Abstract: Disclosed is an electrical topology of an integrated DC charging station and an operation control method. The electrical topology comprises a supply side DC bus, K discrete charging pile units and a mutual aid total DC bus; each charging pile unit comprises an input DC bus, a mutual aid sub-DC bus, an output DC bus, N isolation branches, a non-isolation DC/DC module and an output terminal, the input DC bus is connected to the supply side DC bus, and the mutual aid sub-DC bus of each charging pile unit is connected to the mutual aid total DC bus; the isolation branch comprises an output branch and a mutual aid branch; and when all the output branches of one charging pile, unit are started and the output power cannot meet the required power, the mutual aid branches of other charging pile units are started to meet the required power.