Patents by Inventor Jian S. Zhou

Jian S. Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9268064
    Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: February 23, 2016
    Assignee: Novartis AG
    Inventors: Frank Chang, Jian S. Zhou
  • Publication number: 20150301228
    Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Inventors: Frank Chang, Jian S. Zhou
  • Patent number: 9097840
    Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: August 4, 2015
    Assignee: Novartis AG
    Inventors: Frank Chang, Jian S. Zhou
  • Publication number: 20140171539
    Abstract: The invention provides an amphiphilic siloxane-containing (meth)acrylamide which comprises one sole (meth)acrylamido group, one sole tris(trimethylsiloxy)silyl group, and one polyethylene glycol segment which is either dangling polymer chain or a hydrophilic linker between the (meth)acrylamido group and the tris(trimethylsiloxy)silyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing (meth)acrylamido group, one tris(trimethylsiloxy)silyl group of the invention.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 19, 2014
    Applicant: NOVARTIS AG
    Inventors: Frank Chang, Jian S. Zhou
  • Patent number: 8283429
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: October 9, 2012
    Assignee: Novartis AG
    Inventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
  • Patent number: 8263679
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: September 11, 2012
    Assignee: Novartis AG
    Inventors: Jian S. Zhou, Dawn A. Smith
  • Publication number: 20120046382
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 23, 2012
    Inventors: Jian S. Zhou, Dawn A. Smith
  • Publication number: 20120041097
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 16, 2012
    Inventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
  • Patent number: 8071658
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: December 6, 2011
    Assignee: Novartis AG
    Inventors: Jian S. Zhou, Dawn A. Smith
  • Patent number: 8071703
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: December 6, 2011
    Assignee: Novartis AG
    Inventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
  • Patent number: 7927519
    Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring an analyte of interest in a body fluid and a method for making the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of a reflection hologram therein or thereon, wherein the reflection hologram is produced in a crosslinkable and/or polymerizable fluid material. The polymer matrix contains a molecular sensing moiety which interacts or reacts with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: April 19, 2011
    Assignee: Eyesense AG
    Inventors: Angelika Maria Domschke, Xiaodong Hu, Jian S. Zhou
  • Publication number: 20080231798
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling polysiloxane-containing polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a relatively high oxygen permeability, a reduced elastic modulus, and a relatively high ion permeability. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Application
    Filed: March 21, 2008
    Publication date: September 25, 2008
    Inventors: Jian S. Zhou, Dawn A. Smith
  • Publication number: 20080234457
    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
    Type: Application
    Filed: March 21, 2008
    Publication date: September 25, 2008
    Inventors: Jian S. Zhou, Frank Chang, Arturo Norberto Medina, Robert Scott
  • Patent number: 6838244
    Abstract: Oligonucleotide molecules labeled with a plurality of fluorophores of one or more types embedded in the backbone of said oligonucleotide, wherein at least one of said fluorophores is not located at either the 3? or 5? terminus of said oligonucleotide. The invention further provide methods for using the subject labeled oligonucleotides in detecting biological molecules, sequencing DNA molecules and particularly generating cDNA molecules for characterizing the differential expression of genes.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: January 4, 2005
    Assignee: Monsanto Technology LLC
    Inventors: Wan-Liang Robert Li, Jian S. Zhou