Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: A synthetic ripple regulator including frequency control based on a reference clock. The regulator includes an error network, a ripple detector, a combiner, a ripple generator, a comparator network and a phase comparator. The error network provides an error signal indicative of relative error of the output voltage. The ripple detector provides a ramp control signal based on the input and output voltages and a pulse control signal. The combiner adjusts the ramp control signal based on a frequency compensation signal to provide an adjusted ramp control signal. The ripple generator develops a ripple control signal based on the adjusted ramp control signal. The comparator network develops the pulse control signal to control switching based on the error signal and the ripple control signal. The phase comparator compares the pulse control signal with the reference clock and provides the frequency compensation signal.

Abstract: A synthetic ripple regulator including frequency control based on a reference clock. The regulator includes an error network, a ripple detector, a combiner, a ripple generator, a comparator network and a phase comparator. The error network provides an error signal indicative of relative error of the output voltage. The ripple detector provides a ramp control signal based on the input and output voltages and a pulse control signal. The combiner adjusts the ramp control signal based on a frequency compensation signal to provide an adjusted ramp control signal. The ripple generator develops a ripple control signal based on the adjusted ramp control signal. The comparator network develops the pulse control signal to control switching based on the error signal and the ripple control signal. The phase comparator compares the pulse control signal with the reference clock and provides the frequency compensation signal.