Abstract: Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

Abstract: Disclosed is a nut assembly for an electronic expansion valve, an electronic expansion valve, and a limiting element mounting method. The nut assembly comprises a nut base, having a first end and a second end opposite to each other; a stop guide rail, sleeved on the nut base; a check ring, sleeved on the nut base and capable of helically rotating with respect to the nut base along the stop guide rail; and a limiting element, provided at the first end of the nut base The limiting element mounting method comprises the following steps: enabling the limiting element to be sleeved on the nut base, and enabling a second limiting boss to extend from a groove opening of a first limiting groove into the first limiting groove; and enabling, by means of the limiting element, the second limiting boss to slide into a corresponding second limiting groove.

Abstract: An intelligent orthopedic external fixing system based on a cloud platform, includes a cloud platform, an intelligent recognition unit and a Taylor spatial frame manufacturing module, wherein the intelligent recognition unit comprises an osteotrauma reconstruction module, a three-dimensional medical model registration module, a condition characteristic extraction module, an image recognition module, a personalized designed module and a basic module. According to the disclosure, the cloud platform integrates medical registration technology, computer image recognition technology, three-dimensional reconstruction technology and deep machine learning technology.

Abstract: A semiconductor device is provided. The semiconductor device incudes: a first sub-semiconductor structure including a dielectric layer; and a second sub-semiconductor structure, at least including a carrier substrate, and being bonded to the first sub-semiconductor structure. The first sub-semiconductor structure or the second sub-semiconductor structure includes a charge accumulation preventing layer, and the charge accumulation preventing layer is disposed between the carrier substrate and the dielectric layer, and is configured to avoid an undesired conductive channel from being generated due to charge accumulation on a surface of the carrier substrate.

Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: A radiation therapy system may include a magnetic resonance imaging (MRI) device configured to acquire MRI data with respect to a region of interest (ROI). The MRI device may include a main magnet that is around a longitudinal axis and configured to generate a magnetic field. The MRI device may also include a radiation therapy device configured to perform a treatment on at least one portion of the ROI by delivering, based on the MRI data, therapeutic radiation to the at least one portion of the ROI. The radiation therapy device may be rotatable around the longitudinal axis. The MRI device may also include a first shielding structure configured to provide interference shielding for the MRI device or the radiation therapy device. The radiation therapy device may be rotatable relative to the first shielding structure around the longitudinal axis.

Abstract: Embodiments of the present disclosure relate to a D-amino acid oxidase mutant and application in preparing L-glufosinate thereof. The D-amino acid oxidase mutant has an amino acid substitution at at least one of position 62 and position 226 of an amino acid sequence of the D-amino acid oxidase mutant when compared to an amino acid sequence of a D-amino acid oxidase as set forth in SEQ ID NO. 1, the position 62 and position 226 being defined with reference to SEQ ID NO. 1, and the amino acid sequence of the D-amino acid oxidase mutant having at least 90% identity to SEQ ID NO. 1.

Abstract: A non-invasive time domain reflection probe calibration method includes: using different volume ratio of ethanol and deionized water mixed solution to calculate a test target's medium weight coefficient and waveguide length of the non-invasive time domain reflection probes; using different concentrations of NaCl solutions to calibrate a waveguide geometric dimensioning of the non-invasive time domain reflection probes; preparing compacted soil samples with known different moisture contents and densities, and calibrating a correlation parameter of compacted soil samples' dielectric constant and conductivity with moisture content and density. The method not only determines the sensitivity of the test target medium of the non-invasive time domain reflection probes, but also obtains the waveguide length and geometric dimensioning of the probe, and realizes an accurate test of moisture content and density of the soil.

Abstract: The present invention relates to a molecular marker, a specific primer pair, and an identification method of the high-quality Ganoderma lucidum strain HMGIM-M624. The high-quality Ganoderma lucidum strain HMGIM-M624 was preserved in Guangdong Microbial Culture Collection Center (address: 5th Floor, No. 59 Building of No. 100 Yard, Mid. Xianlie Road, Guangzhou City) with the preservation number of GDMCC No: 60889 on Nov. 7, 2019. The molecular marker is an InDel molecular marker. The high-quality Ganoderma lucidum strain HMGIM-M624 has a base deletion of CATGCTGTA at the 246451th-246460th site of the chromosome sca34. The present invention provides reagents for detecting the molecular marker of the high-quality Ganoderma lucidum strain HMGIM-M624. The reagents can distinguish the high-quality Ganoderma lucidum strain HMGIM-M624 from the other 11 G. lucidum strains for commercial cultivation, thus specifically identifying the high-quality Ganoderma lucidum strain HMGIM-M624.

Abstract: According to implementations of the present disclosure, there is proposed a solution for analyzing a data table in response to a user input. In this solution, a user input in a cell of a data table is determined. The data table comprises a plurality of cells arranged in rows and columns. An analysis operation for the data table is determined based on semantics of the data table and the user input, the analysis operation corresponding to the user input. Further, a result of the analysis operation is presented in a region of the data table related to the cell. In this way, grid characteristics of the data table can be utilized to provide the result of the analysis operation as desired by a user and simple, efficient and user-friendly data analysis can be facilitated.

Abstract: A display panel includes a plurality of sub-panels tiled in sequence along a first direction. The sub-panels have a first edge and a second edge in the first direction. The sub-panels include a column of first pixels closest to the first edge, a column of second pixels closest to the second edge, and a plurality of columns of third pixels between the column of first pixels and the column of second pixels. A sum of a distance between effective display bodies in the first pixels and the first edge and a distance between effective display bodies in the second pixels and the second edge is smaller than a spacing between effective display bodies in two adjacent columns of the third pixels.

Abstract: A display substrate and a display apparatus are provided. The display substrate includes a base substrate; sub-pixels arranged in an array and on the base substrate; data line groups on the base substrate; each data line group includes data lines, each of which is connected to one column of sub-pixels; data selectors on the base substrate and connected to the data line groups in a one-to-one correspondence; data lines in a same data line group are connected to a same data selector; and data selection signal lines, wherein different data selection signal lines output different data selection signals; and different data lines connected to a same data selector correspond to different data selection signal lines, respectively. The display panel provided may effectively reduce the resistance on the data selection signal lines, thereby reducing the delay of the data selection signals and further improving the charging uniformity of sub-pixels.

Abstract: Embodiments of the disclosure provide a method and apparatus for running a service, and an electronic device. An embodiment of the method includes: determining a target deployment manner of a graphics processing unit (GPU) according to performance data of each service in a service set, where the deployment manner includes: dividing the GPU into sub-GPUs of a respective size and determining a service configured to be run by each sub-GPU; and switching, for the service in the service set, running of the service from a sub-GPU indicated by a current deployment manner to a sub-GPU indicated by the target deployment manner. According to the embodiment, waste of the GPU can be reduced by running a plurality of services on the GPU.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for improving visibility generation in tile-based GPU architectures. A graphics processor may perform a first binning pass associated with visibility information for each of a plurality of primitives in at least one frame. The visibility information for each of the plurality of primitives may correspond to a visible indication or an invisible indication. The graphics processor may update a depth buffer based on the visibility information for all of the plurality of primitives in the at least one frame. The graphics processor may perform a second binning pass for each of the visible set of primitives based on the updated depth buffer. The graphics processor may store at least one of the updated visibility information or updated position data for all primitives in the visible set of primitives from the second binning pass.

Abstract: A display substrate and a display apparatus are provided. The display substrate includes a base substrate, a first conductive layer, a second conductive layer and an insulation layer. The first conductive layer is on a side of the base substrate and includes a first conductive part extending in a first direction, the second conductive layer is on a side of the first conductive layer facing away from the base substrate, and the insulation layer is located between the first conductive layer and the second conductive layer. At least one first conductive part includes a first hollowed-out portion including a plurality of groove structures distributed in a second direction and extending in the first direction. The first direction and the second direction produce angles.

Abstract: A filecoin cluster data transmission method and system based on RDMA, including: providing a RDMA interface; receiving and encapsulating sector data by a first node, invoking the RDMA interface to transmit the sector data, serially transmitting the sector data to a next encapsulation node; when receiving the sector data from a previous node, invoking the RDMA interface to directly transmit the sector data to a user mode memory of the node for encapsulation; invoking the RDMA interface to serially transmit the sector data back to the HCA card, and transmitting the sector data to a next node; receiving, by a last node, the sector data, invoking the RDMA interface to directly transmit the sector data to the user mode memory of the last node; invoking the RDMA interface to serially transmit the sector data back to the HCA card of the last node, and transmitting the sector data to distributed storage.

Abstract: An online concierge system determines a quantity of a resource available in a timeslot to fulfill orders during the timeslot. The orders include immediate orders placed during the timeslot and scheduled orders that are scheduled for fulfillment during the timeslot. The online concierge system applies the quantity of the resource to a machine learning model to produce a predicted relationship between a value of a fulfillment metric and an allocation of the quantity of the resource reserved for immediate orders. The online concierge system determines, based on the predicted relationship, an expected optimal allocation of the quantity of the resource that maximizes the fulfillment metric. The online concierge system reserves the expected optimal allocation of the quantity of the resource for immediate orders.