Patents by Inventor Jiande Chen
Jiande Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180193643Abstract: The present invention provides a method and device for sacral nerve stimulation (SNS) for treatment of disease, such as inflammatory disease. The SNS therapy is automatically adjusted in response to detection of physiological data from the patient.Type: ApplicationFiled: June 3, 2016Publication date: July 12, 2018Inventors: Jiande Chen, Jieyun Yin, Pankaj J. Pasricha
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Patent number: 9919152Abstract: Systems and methods for gastrointestinal electrical stimulation to treat abnormalities in gastrointestinal motility are provided. In some embodiments, a system for relieving ileus includes an intraluminal catheter comprising: a catheter body having a proximal tip and a distal tip and a duodenal portion proximal to the distal tip of the catheter; and at least one electrode pair disposed along the duodenal portion of the intraluminal catheter, the at least one electrode pair being configured to detect a sensing information indicative of myoelectric activity of a patient and to provide stimulation energy; a sensing system in communication with the at least one electrode pair to receive the sensing information; and an energy delivery system in communication with the at least one electrode pair and the sensing system, the electrical energy delivery system being configured to delivery energy to the patient through the at least one second electrode pair based on the sensing information from the sensing system.Type: GrantFiled: November 5, 2015Date of Patent: March 20, 2018Assignee: Enterastim, Inc.Inventors: Andy H. Levine, Michael Partsch, Jay Pasricha, Jiande Chen
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Publication number: 20170319848Abstract: Systems and methods for gastrointestinal electrical stimulation to treat abnormalities in gastrointestinal motility are provided. In some embodiments, a system for relieving ileus includes an intraluminal catheter comprising: a catheter body having a proximal tip and a distal tip and a duodenal portion proximal to the distal tip of the catheter; and at least one electrode pair disposed along the duodenal portion of the intraluminal catheter, the at least one electrode pair being configured to detect a sensing information indicative of myoelectric activity of a patient and to provide stimulation energy; a sensing system in communication with the at least one electrode pair to receive the sensing information; and an energy delivery system in communication with the at least one electrode pair and the sensing system, the electrical energy delivery system being configured to delivery energy to the patient through the at least one second electrode pair based on the sensing information from the sensing system.Type: ApplicationFiled: July 26, 2017Publication date: November 9, 2017Inventors: Andy H. Levine, Michael Partsch, Jay Pasricha, Jiande Chen
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Patent number: 9549872Abstract: Certain embodiments are directed to methods of treating a metabolic disease in a subject using a fully implantable electrical stimulation system to provide or administer a therapy. In certain aspects a stimulation lead is implanted proximally to a stomach acupoint, the stimulation lead being coupled to an implantable signal generator; and stimulating the acupoints using the signal generator to treat the metabolic disease.Type: GrantFiled: August 15, 2013Date of Patent: January 24, 2017Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Jiande Chen, Jieyun Yin
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Publication number: 20160121111Abstract: Systems and methods for gastrointestinal electrical stimulation to treat abnormalities in gastrointestinal motility are provided. In some embodiments, a system for relieving ileus includes an intraluminal catheter comprising: a catheter body having a proximal tip and a distal tip and a duodenal portion proximal to the distal tip of the catheter; and at least one electrode pair disposed along the duodenal portion of the intraluminal catheter, the at least one electrode pair being configured to detect a sensing information indicative of myoelectric activity of a patient and to provide stimulation energy; a sensing system in communication with the at least one electrode pair to receive the sensing information; and an energy delivery system in communication with the at least one electrode pair and the sensing system, the electrical energy delivery system being configured to delivery energy to the patient through the at least one second electrode pair based on the sensing information from the sensing system.Type: ApplicationFiled: November 5, 2015Publication date: May 5, 2016Inventors: Andy H. Levine, Michael Partsch, Jay Pasricha, Jiande Chen
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Publication number: 20140371834Abstract: The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract.Type: ApplicationFiled: May 24, 2014Publication date: December 18, 2014Applicant: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pankaj Jay Pasricha
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Patent number: 8761903Abstract: The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract.Type: GrantFiled: March 2, 2007Date of Patent: June 24, 2014Assignee: The Board of Regents of the University of TexasInventors: Jiande Chen, Pankaj Jay Pasricha
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Publication number: 20140051906Abstract: A method of providing an implantable stimulation system to achieve chronic or permanent electrical stimulation of acupuncture points to treat a variety of chronic disorders.Type: ApplicationFiled: August 15, 2013Publication date: February 20, 2014Applicant: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Jieyun Yin
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Publication number: 20140012348Abstract: The disclosure is directed to techniques for delivering electrical stimulation therapy to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.Type: ApplicationFiled: September 13, 2013Publication date: January 9, 2014Applicant: Medtronic, Inc.Inventors: Warren L. Starkebaum, Jiande Chen, Elizabeth D. Firestone, Roland C. Maude-Griffin
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Patent number: 8594811Abstract: The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. The invention is further directed to a method for reducing weight in a subject, again using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the stomach. The invention is further directed to a method of providing electrical field stimulation to a gastrointestinal organ, as well as a method of providing an electrical potential gradient in a gastrointestinal organ. Further provided is a method of stimulating the vagus nerve of a subject. Additionally provided is a method of placing a device in the gastrointestinal tract or wall of a subject from the exterior of the subject, using a needle to insert the device.Type: GrantFiled: August 19, 2004Date of Patent: November 26, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pankaj Jay Pasricha
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Patent number: 8565885Abstract: The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways.Type: GrantFiled: January 30, 2009Date of Patent: October 22, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pasricha Pankaj Jay
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Patent number: 8538532Abstract: In some examples, electrical stimulation therapy is delivered to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.Type: GrantFiled: March 2, 2010Date of Patent: September 17, 2013Assignee: Medtronic, Inc.Inventors: Warren L. Starkebaum, Jiande Chen, Elizabeth D. Firestone, Roland C. Maude-Griffin
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Patent number: 8467884Abstract: The present invention is directed to a method of stimulating the vagus nerve of a subject.Type: GrantFiled: March 2, 2007Date of Patent: June 18, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pankaj Jay Pasricha
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Patent number: 8467874Abstract: The disclosure provides a method of treatment for obesity, in an individual in need thereof, by administering electrical stimulation at dual sites in the gastrointestinal tract. The electrical stimulations are administered by positioning bipolar stimulatory electrodes in contact with the gastric and dudenol cavities, along afferent vagal neural pathways, in the gastrointestinal tract. The electrical stimulations thus administered, activate the vagal afferents associated with the gastric and dudenol sites in the gastrointestinal tract. The activation of vagal afferents modulates the gastrointestinal peptide satiety hormones. Further, the disclosure provides a method of treatment for eating disorders, in an individual in need thereof, by administering electrical stimulation at dual sites, along afferent vagal neural pathways, in the gastrointestinal tract.Type: GrantFiled: July 19, 2010Date of Patent: June 18, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pankaj Jay Pasricha
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Patent number: 8417331Abstract: The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.Type: GrantFiled: January 19, 2011Date of Patent: April 9, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Pankaj Jay Pasricha, Jiande Chen
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Patent number: 8412319Abstract: The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.Type: GrantFiled: January 13, 2011Date of Patent: April 2, 2013Assignee: The Board of Regents of the University of Texas SystemInventors: Pankaj J. Pasricha, Jiande Chen
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Patent number: 8211941Abstract: One of the major disabling symptoms of gastroparesis is nausea and vomiting which can be difficult to control with currently available treatments. It is postulated that signaling of gastrointestinal causes of nausea starts with activation of vagal afferent nerves that trigger the central emetic pathway. Most vagal afferent nerves are unmyelinated C-fibers, many of which express the vanilloid receptor TRPV1 and respond to capsaicin. Resiniferatoxin is a very potent capsaicin analogue that has a much more favorable ratio of desensitization to excitation than capsaicin leading to more effective desensitization without irritation. The present invention describes methods of alleviating acute or chronic nausea, vomiting by the administration of resiniferatoxin.Type: GrantFiled: April 11, 2008Date of Patent: July 3, 2012Assignee: The Board of Regents of the University of Texas SystemInventors: Pankaj J. Pasricha, Jiande Chen, Rami Hawari
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Patent number: 8185206Abstract: The disclosure is directed to techniques for delivering electrical stimulation therapy to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.Type: GrantFiled: May 17, 2007Date of Patent: May 22, 2012Assignee: Medtronic, Inc.Inventors: Warren L. Starkebaum, Jiande Chen
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Patent number: 7967750Abstract: The present invention provides a device and methods of lie detection utilizing electrogastrography to monitor changes in the gastric electric rhythm of a subject. Also provided are methods of discriminating between the stress of deception induced in a subject during a lie detection examination and the stress of the examination itself.Type: GrantFiled: April 13, 2007Date of Patent: June 28, 2011Assignee: The Board of Regents of the University of Texas SystemInventors: Jiande Chen, Pankaj J. Pasricha, Trisha Pasricha
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Publication number: 20110118747Abstract: The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.Type: ApplicationFiled: January 19, 2011Publication date: May 19, 2011Inventors: Pankaj J. Pasricha, Jiande Chen