Abstract: Provided is a novel neutralizing antibody against spike protein of SARS-COV-2, and the antigen binding fragments thereof. Pharmaceutical composition and kits comprising the same, and the uses thereof are also provided.

Abstract: The present invention provides ocular cells, genetically modified by a CRISPR system targeting the expression of B2M for ocular cell therapy. The invention further provides methods of generating an expanded population of genetically modified ocular cells, for example limbal stem cells (LSCs) or corneal endothelial cells (CECs), wherein the cells are expanded involving the use of a LATS inhibitor and the expression of B2M in the cells has been reduced or eliminated. The present invention also provides cell populations, preparations, uses and methods of therapy comprising said cells.

Abstract: A rotary engine includes a housing, a crank dual-slider connecting rod mechanism, and rotary casings. The vertically arranged sliding grooves are provided in the housing. The crank dual-slider connecting rod mechanism is mounted on the housing. Sliders of the crank dual-slider connecting rod mechanism are respectively located in the sliding groove. The sliders are driven by a rotation of a crank to periodically compress a gas in the sliding grooves. The two rotary casings configured to rotate synchronously are mounted on an outer side of the housing. Each of the rotary casings is provided with a combustion chamber. Any of the rotary casings is in a transmission connection with a main shaft via a transmission system. The rotary casings drive the main shaft to rotate through a combustion of a compressed gas in the combustion chambers. The rotary engine achieves a good seal.

Abstract: The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.

Abstract: A rotary engine includes a housing, a crank dual-slider connecting rod mechanism, and rotary casings. The vertically arranged sliding grooves are provided in the housing. The crank dual-slider connecting rod mechanism is mounted on the housing. Sliders of the crank dual-slider connecting rod mechanism are respectively located in the sliding groove. The sliders are driven by a rotation of a crank to periodically compress a gas in the sliding grooves. The two rotary casings configured to rotate synchronously are mounted on an outer side of the housing. Each of the rotary casings is provided with a combustion chamber. Any of the rotary casings is in a transmission connection with a main shaft via a transmission system. The rotary casings drive the main shaft to rotate through a combustion of a compressed gas in the combustion chambers. The rotary engine achieves a good seal.

Abstract: The present invention belongs to the field of flame arresters, and discloses a buffered wall flow multi-channels flame arrester. The flame arrester comprises a buffering and splitting cover and a Z-type wall flow multi-channels flame arresting core, wherein the buffering and splitting cover has a round-bottom plain-top cylindrical shape or hemispherical shape, with pinholes distributed in the cover surface, and channels are arranged inside the Z-type wall flow multi-channels flame arresting core. In every two adjacent channels, the inlet of one channel is blocked, and the outlet of the other channel is blocked, and in the height direction in the central cross section of the flame arresting core, pinholes are arranged in the wall surfaces between adjacent channels, and adjacent upper and lower channels constitute a fluid channel.

Abstract: The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.

Abstract: Disclosed are a Acylaminopyrrolo-pyridone represented by general formula I, or a pharmaceutically acceptable salt thereof, or an enantiomer, a diastereomer, a tautomer, a solvate, a polymorph, or a prodrug thereof, a preparation method therefor and use thereof in pharmacy, the definition of each group being as described in the description.

Abstract: Disclosed are a nitrogen-containing fused heterocyclic SHP2 inhibitor compound, a preparation method, and use. The nitrogen-containing fused heterocyclic SHP2 inhibitor compound is represented by formula I below. The compound has high inhibitory activity for an SHP2 enzyme and tumor cell proliferation, and has good druggability.

Abstract: A rotary piston engine is provided. The rotary piston engine includes a shell and a rotor, the rotating rotor is arranged in the shell and divides a rotor cavity into compression chambers with a variable volume, a plurality of combustion chambers rotating around a main shaft of the rotor are arranged on an outer ring of the shell, and any one of the plurality of combustion chambers is communicated with the compression chambers; the plurality of combustion chambers are in a transmission connection with the main shaft of the rotor via a transmission system, and each of the plurality of combustion chambers drives the main shaft of the rotor to rotate by a combustion of a compressed combustible gas mixture. The shell includes an upper cylinder cover and a lower cylinder cover, and a boss of the upper cylinder cover is fitted with a spigot of the lower cylinder cover.

Abstract: The present invention belongs to the field of flame arresters, and discloses a buffered wall flow multi-channels flame arrester. The flame arrester comprises a buffering and splitting cover and a Z-type wall flow multi-channels flame arresting core, wherein the buffering and splitting cover has a round-bottom plain-top cylindrical shape or hemispherical shape, with pinholes distributed in the cover surface, and channels are arranged inside the Z-type wall flow multi-channels flame arresting core. In every two adjacent channels, the inlet of one channel is blocked, and the outlet of the other channel is blocked, and in the height direction in the central cross section of the flame arresting core, pinholes are arranged in the wall surfaces between adjacent channels, and adjacent upper and lower channels constitute a fluid channel.

Abstract: Provided is a fused tri-cyclic compound as PDE3/PDE4 dual inhibitor, and a use thereof in the preparation of drugs for PDE3/PDE4 associated diseases, particularly in medicinal functions such as chronic obstructive pulmonary disease (COPD). Provided are specifically a compound of formula (I) and a pharmaceutically acceptable salt thereof.

Abstract: A rotary piston engine is provided. The rotary piston engine includes a shell and a rotor, the rotating rotor is arranged in the shell and divides a rotor cavity into compression chambers with a variable volume, a plurality of combustion chambers rotating around a main shaft of the rotor are arranged on an outer ring of the shell, and any one of the plurality of combustion chambers is communicated with the compression chambers; the plurality of combustion chambers are in a transmission connection with the main shaft of the rotor via a transmission system, and each of the plurality of combustion chambers drives the main shaft of the rotor to rotate by a combustion of a compressed combustible gas mixture. The shell includes an upper cylinder cover and a lower cylinder cover, and a boss of the upper cylinder cover is fitted with a spigot of the lower cylinder cover.

Abstract: An actuator of a rotary engine that can realize different compression ratios includes three parts: an eccentric shaft, a triangle rotor and a control system. The eccentric shaft includes the front part of the eccentric shaft, the combination of an electric three-jaw and the rear part of the eccentric shaft. The triangle rotor includes the variable volume actuator, the front part of the rotor and the rear part of the rotor. The control system controls expansion and contraction of the electric three-jaw. The eccentric shaft part passes through the triangle rotor part to make the combination of electric three jaw to arrange in the annular groove. The reciprocating motion of the variable volume actuator is controlled by the expansion and contraction of the claw top of the electric three-jaw. Engine compression ratio may therefore be adjusted using the compression ratio adjustment system.

Abstract: The present invention provides ocular cells, genetically modified by a CRISPR system targeting the expression of B2M for ocular cell therapy. The invention further provides methods of generating an expanded population of genetically modified ocular cells, for example limbal stem cells (LSCs) or corneal endothelial cells (CECs), wherein the cells are expanded involving the use of a LATS inhibitor and the expression of B2M in the cells has been reduced or eliminated. The present invention also provides a cell populations, preparations, uses and methods of therapy comprising said cells.

Abstract: A composite intake system and method of operating a rotary engine with variable intake manifold is provided. The system includes two switching valves in a secondary intake switching tube to change the intake method. When the rotary engine works under low speed conditions, it adopts the long intake manifold and the side-intake mode. When the rotary engine works under medium and high speed conditions, it uses the short intake manifold and the composite-intake mode. When the rotary engine works under ultra high speed conditions, it takes the short intake manifold and the peripheral-intake mode.

Abstract: The present invention provides an actuator that can realize the different compression ratios of the rotary engine. The invention actuator described above, includes three parts: the eccentric shaft part, the triangle rotor part and the control system. The eccentric shaft part which is described above, includes the front part of the eccentric shaft, the combination of electric three jaw and the rear part of the eccentric shaft. The triangle rotor part which is described above, includes the variable volume actuator, the front part of the rotor and the rear part of the rotor. The control system which is described above, includes the control system of electric three jaw and the rotating joint. The expansion and contraction of the electric three jaw described above, are controlled by the control system of electric three jaw described above.

Abstract: The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.

Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

Abstract: A composite intake system and method of operating a rotary engine with variable intake manifold is provided. The system includes two switching valves in a secondary intake switching tube to change the intake method. When the rotary engine works under low speed conditions, it adopts the long intake manifold and the side-intake mode. When the rotary engine works under medium and high speed conditions, it uses the short intake manifold and the composite-intake mode. When the rotary engine works under ultra high speed conditions, it takes the short intake manifold and the peripheral-intake mode.