Publication number: 20230381348
Abstract: The present disclosure relates to the technical field of chelating agents, in particular to a bifunctional macrocyclic chelate, a conjugate, a metal complex, and use thereof. The bifunctional macrocyclic chelate is a compound of following Formula I or an isomer thereof, wherein R1, R3, R5, and R7 are each independently selected from alkyls or long-chain polymer groups, R2, R4, R6, and R8 are each independently selected from functional groups, Ra, Rb, Rc, and Rd are each independently selected from any one of H, substituted or unsubstituted alkyls, halogens, substituted or unsubstituted cyano groups, substituted or unsubstituted ester groups, substituted or unsubstituted alkoxys, substituted or unsubstituted amines, and substituted or unsubstituted aryls, ring The bifunctional macrocyclic chelate can complex most nuclides, and expand use of the bifunctional macrocyclic chelate, and the metal complex chelating different nuclides can realize integration of diagnosis and treatment.
Type:
Application
Filed:
July 31, 2023
Publication date:
November 30, 2023
Applicant:
Jyams Pet Research & Development Limited
Inventors:
Jianfeng Xu, Zheng Wang, Wenbin Fan, Fei Cai, Huanhuan Yin, Zhigang Luo