Abstract: An integrated optical transceiver includes an optical receiver that produces a first electrical signal at a reception electrical interface in response to a first optical signal, an optical transmitter that emits a second optical signal in response to a second electrical signal received at a transmission electrical interface, a first optical branching device that receives the first optical signal at an reception optical interface and to direct at least a portion of the first optical signal to the optical receiver, and a second optical branching device that directs the second optical signal to an transmission optical interface. The first optical branching device directs at least a portion of the first optical signal to the second optical branching device. The second optical branching device directs the portion of the first optical signal received from the first optical branching device to the transmission optical interface.

Abstract: An optical transceiver includes an electric terminal that can receive power from a host equipment and provide a power supply voltage to the optical transceiver, and a power failure monitor circuit that can detect an imminent loss of the power supply voltage. The power failure monitor circuit can produce a dying-gasp control signal when such imminent loss of power supply voltage is detected or when a disabling control signal is received from the host equipment. A driver can receive the dying-gasp control signal. An optical transmitter is powered by the power supply voltage and can emit a first optical signal under the control of the driver. The driver can modulate an envelope of the first optical signal in response to the dying-gasp control signal to produce a modulated envelope comprising a first dying gasp signal.

Abstract: An integrated optical transceiver includes an optical receiver that produces a first electrical signal at a reception electrical interface in response to a first optical signal, an optical transmitter that emits a second optical signal in response to a second electrical signal received at a transmission electrical interface, a first optical branching device that receives the first optical signal at an reception optical interface and to direct at least a portion of the first optical signal to the optical receiver, and a second optical branching device that directs the second optical signal to an transmission optical interface. The first optical branching device directs at least a portion of the first optical signal to the second optical branching device. The second optical branching device directs the portion of the first optical signal received from the first optical branching device to the transmission optical interface.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: An integrated optical transceiver includes an optical receiver that receives a first optical signal that comprises input user data and a first modulation signal. The first modulation signal includes first management information. The optical receiver can output a first electrical signal comprising the first modulation signal and to output a second electrical signal comprising the input user data in response to the first optical signal. A processing unit can demodulate the first electrical signal to extract the first management information. The processing unit can produce a modulation control signal in response to second management information. An optical transmitter can output a second optical signal in response to the modulation control signal and a third electrical signal comprising output user data.

Abstract: The invention features compositions relating to antibodies that specifically bind to the protective antigen of Bacillus anthracis, fragments thereof, and nucleic acids encoding same. The invention further features methods of using such compositions.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a marnmal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: The number of optical channels that may be used to transmit information/data is greatly enhanced using an optical transmission facility having a transmitter that outputs optical signals having respective wavelengths within a first bandwidth, e.g., the C band, combines the latter signal with an optical signal having a wavelength between the first bandwidth and a second bandwidth, e.g., the L-band, and, using a non-linear frequency converter, processes the combined signal to form at least optical signals having wavelengths within the second bandwidth that correspond with the wavelengths of the optical signals within the first bandwidth. In this way, equipment designed for the C band may also be used to process optical signals with another, second band.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a springiness-1-phosphate lease (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

Abstract: In an optically amplified wavelength division multiplexed (WDM) system having a WDM signal comprising a plurality of optical channels, the per-channel gain of the optical channels is kept relatively constant despite changes in input power at the optical amplifier, such as when individual optical channels of the WDM signal are added and dropped. More specifically, gain of an optical amplifier is controlled by controlling the amount of pump power supplied to the optical amplifier as a function of changes in input power which are measured in a feed-forward monitoring path. The amount of pump power for effecting gain control is adjusted according to a scaled relationship to the measured input power of the optical amplifier. By controlling the pump power directly in response to changes in input power, gain of the optical amplifier can be controlled within a sub-microsecond time scale from the time that a change in input power is detected.

Abstract: The present invention relates generally to the field of optical transmission and particularly to a method and a system for controlling optical amplification in wavelength division multiplex optical transmission. WDM systems currently under development will have eighty or more channels, i.e., modulated optical signals with different wavelengths (known as Dense Wavelength Division Multiplexing, DWDM). These DWDM systems are demanding optical amplifiers which, especially considering the cascadation of a plurality of optical amplifiers along the transmission path of the DWDM system, have only very limited tolerances in certain parameters. Among these parameters gain flatness and gain tilt are of special importance. The present invention discloses a method and a system which make use of auxiliary optical signals having a given power level which is equal for all auxiliary signals.

Abstract: An optical amplifier is adapted to cancel the Raman gain of an optical transmission path that degrades those optical signals occupying the low end of the bandwidth such that the power is transferred from the latter signals to the optical signals occupying the high end of the bandwidth. More specifically, the optical amplifier adjusts the gain that it applies to the optical signals so that it favors the signal components at the low end of the bandwidth.

Abstract: An optical amplifier that receives an optical signal at an input of the optical amplifier is arranged so that it amplifies the signal and then adjusts the level of the amplified input signal to a predetermined level. The optical amplifier, which includes a filter to substantially decrease the wavelength dependence of the optical amplifier, then amplifies the adjusted signal and supplies the resulting signal to an output.