Patents by Inventor Jianjun Guan
Jianjun Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230302191Abstract: In one aspect, a composition for sustained release of oxygen to a tissue is disclosed that includes at least one core-shell oxygen release microsphere (ORM), wherein the core includes a water-soluble polymer-reactive oxygen species (ROS) complex and the shell includes a biodegradable polymer conjugated to a ROS-scavenging enzyme. In some aspects, the reactive oxygen species includes hydrogen peroxide (H2O2), the ROS-scavenging enzyme includes catalase, the water-soluble polymer includes polyvinylpyrrolidone (PVP), and the biodegradable polymer includes poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-co-acrylate-oligolactide-co-Nacryloxysuccinimide)[poly(NIPAAm-co-HEMA-co-AOLA-co-NAS)].Type: ApplicationFiled: January 31, 2023Publication date: September 28, 2023Applicant: Washington UniversityInventors: Hong Niu, Ya Guan, Jianjun Guan
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Publication number: 20220370325Abstract: Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester-based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided.Type: ApplicationFiled: July 22, 2022Publication date: November 24, 2022Applicant: OHIO STATE INNOVATION FOUNDATIONInventors: Jianjie MA, Jianjun GUAN, Haichang LI, Hong NIU, Ya GUAN, Tao TAN
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Publication number: 20210244851Abstract: Methods and formulations for promoting the healing of fracture nonunion sites under inflammatory conditions. The formulation includes a flexible biodegradable scaffold loaded with therapeutically effective amounts of CXCL12 and SPPI encapsulated in biodegradable microspheres. The method includes applying the formulation directly to a region of a fracture nonunion to effect sustained local release of the therapeutically effective amounts of CXCL12 and SPPI to the fracture nonunion region.Type: ApplicationFiled: February 8, 2021Publication date: August 12, 2021Applicant: Washington UniversityInventors: Jie Shen, Jianjun Guan
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Patent number: 9968714Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.Type: GrantFiled: January 15, 2015Date of Patent: May 15, 2018Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
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Patent number: 9408855Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.Type: GrantFiled: January 28, 2014Date of Patent: August 9, 2016Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Kazuro Lee Fujimoto, Jianjun Guan, Zuwei Ma, William R. Wagner
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Publication number: 20150132251Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.Type: ApplicationFiled: January 15, 2015Publication date: May 14, 2015Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
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Patent number: 8974542Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.Type: GrantFiled: June 27, 2007Date of Patent: March 10, 2015Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Kazuro Lee Fujimoto, Kimimasa Tobita, Jianjun Guan, William R. Wagner, Bradley Barth Keller
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Patent number: 8889791Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.Type: GrantFiled: October 10, 2007Date of Patent: November 18, 2014Assignee: University of Pittsburgh-Of the Commonwealth System of Higher EducationInventors: Jianjun Guan, William R. Wagner, Kazuro Lee Fujimoto
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Publication number: 20140213517Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.Type: ApplicationFiled: January 28, 2014Publication date: July 31, 2014Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Kazuro Lee Fujimoto, Jianjun Guan, Zuwei Ma, William R. Wagner
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Patent number: 8673295Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.Type: GrantFiled: April 30, 2010Date of Patent: March 18, 2014Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Kazuro Lee Fujimoto, Zuwei Ma, Jianjun Guan, William R. Wagner
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Patent number: 8535719Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.Type: GrantFiled: July 6, 2007Date of Patent: September 17, 2013Assignee: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
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Publication number: 20120156176Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.Type: ApplicationFiled: April 30, 2010Publication date: June 21, 2012Applicant: University of Pittsburgh-Of the Commonwealth SysteInventors: Kazuro Lee Fujimoto, Zuwei Ma, Jianjun Guan, William R. Wagner
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Publication number: 20120071407Abstract: A novel method of treating a wound is provided. The method comprises administering a therapeutically effective amount of periostin to the wound.Type: ApplicationFiled: June 17, 2011Publication date: March 22, 2012Inventors: Douglas Hamilton, Christopher Elliott, Jianjun Guan
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Publication number: 20090136553Abstract: Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively.Type: ApplicationFiled: September 25, 2008Publication date: May 28, 2009Inventors: Jorg C. Gerlach, Jianjun Guan, Steven R. Little, Alan J. Russell, Jillian Tengood, William R. Wagner
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Publication number: 20080268019Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.Type: ApplicationFiled: July 6, 2007Publication date: October 30, 2008Inventors: Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
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Publication number: 20080109070Abstract: Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.Type: ApplicationFiled: August 10, 2007Publication date: May 8, 2008Inventors: William Wagner, John Stankus, Jianjun Guan, Kazuro Fujimoto, Alejandro Nieponice, Lorenzo Soletti, David Vorp, Michael Sacks, Todd Courtney, John Mayer
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Publication number: 20080096975Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.Type: ApplicationFiled: October 10, 2007Publication date: April 24, 2008Inventors: Jianjun Guan, William Wagner, Kazuro Fujimoto
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Publication number: 20080009830Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.Type: ApplicationFiled: June 27, 2007Publication date: January 10, 2008Inventors: Kazuro Fujimoto, Kimimasa Tobita, Jianjun Guan, William Wagner, Bradley Keller