Abstract: Provided is use of an antibody-drug conjugate targeting Her2 in the preparation of a medicine for treating breast cancer patients with liver metastasis or breast cancer patients without lung metastasis. Compared with a control drug group (lapatinib+capecitabine), the application of the antibody-drug conjugate provided in the treatment of breast cancer patients with liver metastasis and in the treatment of breast cancer patients without lung metastasis can significantly improve the survival time of the patients.

Abstract: A system for unsupervised deep representation learning based on image translation is provided. The system includes an image translation transformation module used for performing a random translation transformation on an image and generating an auxiliary label; an image mask module connected with the image translation transformation module and used for applying a mask to the image after translation transformation; a deep neural network connected with the image mask module and used for predicting an actual auxiliary label of the image after the mask is applied and learning the deep representation of the image; a regression loss function module connected with the deep neural network and used for updating parameters of the deep neural network based on a loss function; and a feature extraction module connected with the deep neural network and used for extracting the representation of the image.

Abstract: A multi-modal adaptive fusion deep clustering model based on an auto-encoder includes an encoder structure, a multi-modal adaptive fusion layer, a decoder structure and a deep embedding clustering layer. The encoder is configured to enable a dataset to be respectively subjected to three types of nonlinear mappings of the auto-encoder, a convolutional auto-encoder and a convolutional variational auto-encoder to obtain potential features, respectively. The multi-modal adaptive feature fusion layer is configured to fuse the potential features into a common subspace in an adaptive spatial feature fusion mode to obtain a fused feature. The decoder is configured to decode the fused feature by using a structure symmetrical to the encoder to obtain a decoded reconstructed dataset. The deep embedding clustering layer is configured to cluster the fused feature Z and obtain a final accuracy ACC by comparing a clustering result with a true label.

Abstract: The present disclosure provides a blending method of high-quality and dual-purpose flour for bread and noodles, belonging to the technical field of flour processing. The method includes: selecting flour of a high-quality and dual-purpose wheat variety for bread and noodles as a high-quality basic flour for blending; according to a large gradient experimental design, selecting a gradient range ratio with a sedimentation value ?46.0 mL and a dough development time ?9.6 min, followed by subdividing for small gradient experiments; selecting a ratio with flour sedimentation value and dough development time that reach an ideal value to blend a large amount of flour; and making bread and noodles for scoring, followed by determining a blending ratio if a scoring result reaches an ideal value.

Abstract: The present invention discloses a method of treating tumor using a novel pyrimidine derivative. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: Provided are a control method and apparatus for increasing the amount of a circulating refrigerant, and an air conditioner. The control method includes: when a refrigerating capacity need is equivalent to a heating capacity need in the operation of an air-conditioning system, determining whether the discharge temperature of a compressor is greater than a preset safety alert value; if the discharge temperature of the compressor is greater than the safety alert value, adjusting the frequency of a fan of an outdoor heat exchanger; and when the discharge temperature of the compressor is not greater than the safety alert value, controlling to stop the adjustment of the frequency of the fan, and maintaining the air-conditioning system to operate at the adjusted current frequency of the fan.

Abstract: The present invention discloses a novel pyrimidine derivative and a preparation process thereof and a use thereof in anti-tumor drugs. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Abstract: Aspects of the disclosure provide a receiver for receiving data over a wired communication channel. The receiver includes an analog front end circuit, a pulse generation circuit and a voltage-controlled oscillator (VCO). The analog front end circuit receives an analog signal carrying data over the wired communication channel, and outputs a data signal with data bit transitions between voltage levels. The pulse generation circuit generates a pulse signal in response to the data bit transitions in the data signal. The voltage-controlled oscillator (VCO) generates an oscillation signal for providing sampling clocks for the data signal. The voltage-controlled oscillator aligns transitions in the oscillation signal to the pulse signal by forcing the oscillation signal to transit voltage levels in response to a pulse in the pulse signal.

Abstract: A short-reach data link receiver includes an edge detector configured to generate a pulse on an edge of a data input, a first clock-data recovery path coupled to an output of the edge detector for recovering a clock and data from the output of the edge detector, a second clock-data recovery path coupled to the output of the edge detector for recovering the clock and data from the output of the edge detector, and a controller configured to alternate between the first and second clock-data recovery paths to recover the clock and data using one of the paths while calibrating the other path. The controller may swap the paths whenever calibration of one path is completed. That may include beginning calibration of the next path immediately after swapping of the paths. Alternatively, power consumption may be reduced by delaying calibration of the next path after swapping of the paths.

Abstract: The present invention discloses a pyrimidine derivative containing one deuterium atom, a preparation process thereof and a use thereof. It is demonstrated through in vivo and in vitro animal experiments that the antitumor activity of the pyrimidine derivative containing one deuterium atom provided in the disclosure is significantly superior to that of the positive drug Tepotinib, and the preparation process is simple and low in cost.

Abstract: A clock-data recovery circuit includes a variable data path delay, an injection-locked oscillator having a free-running frequency, and circuitry for adjusting at least one of the variable data path delay and the free-running frequency, including a counter configured to count repetitions of a bit value in an input data signal, and further being configured to, on occurrence of a first data pattern in the input data signal, indicative of saturation of inter-symbol interference, measure the input data signal at a first clock edge to determine a first data phase measurement value, measure the input data signal at clock centers immediately preceding and immediately following the first clock edge to determine second and third data phase measurement values, and based on first predetermined relationships among the first, second and third data phase measurement values, adjust the variable data path.

Abstract: A short-reach data link receiver includes an edge detector configured to generate a pulse on an edge of a data input, a first clock-data recovery path coupled to an output of the edge detector for recovering a clock and data from the output of the edge detector, a second clock-data recovery path coupled to the output of the edge detector for recovering the clock and data from the output of the edge detector, and a controller configured to alternate between the first and second clock-data recovery paths to recover the clock and data using one of the paths while calibrating the other path. The controller may swap the paths whenever calibration of one path is completed. That may include beginning calibration of the next path immediately after swapping of the paths. Alternatively, power consumption may be reduced by delaying calibration of the next path after swapping of the paths.

Abstract: A short-reach data link receiver includes an edge detector configured to generate a pulse on an edge of a data input, a first clock-data recovery path coupled to an output of the edge detector for recovering a clock and data from the output of the edge detector, a second clock-data recovery path coupled to the output of the edge detector for recovering the clock and data from the output of the edge detector, and a controller configured to alternate between the first and second clock-data recovery paths to recover the clock and data using one of the paths while calibrating the other path. The controller may swap the paths whenever calibration of one path is completed. That may include beginning calibration of the next path immediately after swapping of the paths. Alternatively, power consumption may be reduced by delaying calibration of the next path after swapping of the paths.

Abstract: An on-site hot-melt quick connector for optical fibers comprises a plug housing, a ferrule, an optical fiber telescopic protective tube, a tail end cover, a pressure welding protective tail handle and a compression ring. A front baffle ring is mounted in the plug housing and a rear baffle ring is mounted in the tail end cover. The ferrule and the optical fiber telescopic protective tube are positioned between the front baffle ring and the rear baffle ring and can move in the axial direction. As the quick connector for optical fibers of the invention has a definite space for movement in the axial direction, the optical fibers themselves can move along with the plugging action during butting, avoiding the bending of the optical fibers caused as they are unable to move, thus guaranteeing the transmission quality of the optical signals. The service life of the quick connector is also guaranteed.

Abstract: An on-site hot-melt quick connector for optical fibers comprises a plug housing, a ferrule, an optical fiber telescopic protective tube, a tail end cover, a pressure welding protective tail handle and a compression ring. A front baffle ring is mounted in the plug housing and a rear baffle ring is mounted in the tail end cover. The ferrule and the optical fiber telescopic protective tube are positioned between the front baffle ring and the rear baffle ring and can move in the axial direction. As the quick connector for optical fibers of the invention has a definite space for movement in the axial direction, the optical fibers themselves can move along with the plugging action during butting, avoiding the bending of the optical fibers caused as they are unable to move, thus guaranteeing the transmission quality of the optical signals. The service life of the quick connector is also guaranteed.

Abstract: A phase-locked loop (PLL) with a decreased frequency tuning gain KVCO and a loop filter using capacitor multiplication technique to get high chip area efficiency. To get decreased frequency tuning gain, KVCO, a voltage to current converter in a voltage-controlled oscillator (VCO) in the PLL may comprise a first voltage to current converter and a second voltage to current converter. The trans-conductance of the first voltage to current converter is 1/? of that of the second voltage to current converter, wherein ?>1. The first voltage to current converter is controlled by an output voltage of a loop filter in the PLL, and the second voltage to current converter is controlled by a relative DC voltage, which may be the junction node between R1 and C1 in a loop filer of the PLL. Capacitor multiplication technique may use an auxiliary charge pump to charge or discharge the junction node between R1 and C1 inversely to the main charge pump.