Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

Abstract: An electrochemical device, including a positive electrode, a negative electrode, a separator and an electrolyte. The electrolyte includes a nitrile compound, and the mass percentage of the nitrile compound in the electrolyte is A %; the negative electrode includes a current collector, wherein the current collector comprises a first region and a second region; the first region is provided with a negative electrode active substance layer; the second region does not comprise a negative electrode active substance layer; the area of the second region is B % of the surface area of the current collector; and A×B<600.

Abstract: A compressor (200), comprising: a first rotor (20) being rotatable around a first axis (11), the first rotor (20) comprising a first portion (22) and a second portion (24); and a first shaft (10) carrying the first portion (22) and the second portion (24), the first shaft (10) having a first end (12) and a second end (14) that are oppositely arranged, wherein the first rotor (20) is configured to be applied with a preset acting force in a direction from the first end (12) toward the second end (14) or from the second end (14) toward the first end (12) during rotation. The size of the compressor (200) can be reduced with the displacement of the compressor (200) remaining substantially unchanged.

Abstract: The nucleic acid sequences provided by the present invention comprises sequence HPV16-AVLS1 and sequence HPV16-AVLC1 in a 1:1 ratio; and sequence HPV18-AVLS1 and sequence HPV18-AVLC1 in a 1:1 ratio; the sequence AVLS1 and the sequence AVLC1 comprise two concatenated E6 proteins, two LI short peptides, two L2 short peptides, two concatenated E7 proteins, one PADRE sequence, and one adjuvant sequence respectively; the N-terminal of sequence AVLS1 carries a mouse IgK secretion peptide sequence; the N-terminal of sequence AVLC1 carries a ubiquitin sequence. The nucleic acid sequences provided by the present invention can not only induce high titer antibodies against E6/E7, but also elicit a high level of functional cellular immune, demonstrating excellent preventive and therapeutic effects against tumors related to HPV.

Abstract: The nucleic acid sequences provided by the present invention comprises sequence HPV16-AVLS1 and sequence HPV16-AVLC1 in a 1:1 ratio; and sequence HPV18-AVLS1 and sequence HPV18-AVLC1 in a 1:1 ratio; the sequence AVLS1 and the sequence AVLC1 comprise two concatenated E6 proteins, two LI short peptides, two L2 short peptides, two concatenated E7 proteins, one PADRE sequence, and one adjuvant sequence respectively; the N-terminal of sequence AVLS1 carries a mouse IgK secretion peptide sequence; the N-terminal of sequence AVLC1 carries a ubiquitin sequence. The nucleic acid sequences provided by the present invention can not only induce high titer antibodies against E6/E7, but also elicit a high level of functional cellular immune, demonstrating excellent preventive and therapeutic effects against tumors related to HPV.

Abstract: A valve bridge has a valve bridge body being provided with a main piston chamber, an actuating pin mounting chamber, a main piston, and an actuating pin; an elastic member is arranged between the actuating pin and the actuating pin mounting chamber, and a lower end of the actuating pin extends out of the actuating pin mounting chamber under an elastic force of the elastic member; the valve bridge body is provided with a first oil drainage passage in communication with the main piston chamber, and an interior of the actuating pin is provided with a second oil drainage passage having one end in communication with a return oil chamber of an engine.

Abstract: A valve bridge has a valve bridge body being provided with a main piston chamber, an actuating pin mounting chamber, a main piston, and an actuating pin; an elastic member is arranged between the actuating pin and the actuating pin mounting chamber, and a lower end of the actuating pin extends out of the actuating pin mounting chamber under an elastic force of the elastic member; the valve bridge body is provided with a first oil drainage passage in communication with the main piston chamber, and an interior of the actuating pin is provided with a second oil drainage passage having one end in communication with a return oil chamber of an engine.

Abstract: The present invention discloses a synchronization method suitable for increasing the receiving speed in the receiving part of an orthogonal optical frequency division multiplexing (OOFDM) transceiver.

Abstract: The present invention discloses a method for symbol synchronisation in high speed optical orthogonal frequency division multiplexing (OOFDM) transmission systems via coding the electrical OFDM symbols by adding an independent low power-level alignment signal, converting the encoded signal into the optical domain for transmission, and in the receiver converting the received optical signal to the electrical domain and digitally processing to detect the symbol alignment offset by utilising the independent low-power level alignment signal. The present invention is suitable for point-to-point and point-to-multi-point OOFDM networks and has the additional features of timeslot and frame alignment, compensation for receiver sampling clock offset and providing physical layer network security. The superimposed training signal is a DC offset whose value varies at symbol transitions.

Abstract: The present invention discloses a method for real time optical orthogonal frequency division multiplexing (OOFDM) transceivers by adaptively utilising available channel spectral characteristics.

Abstract: The present invention discloses a method for achieving optimised synchronous clock distribution of point-to-multipoint optical orthogonal frequency division multiplexed networks such that bandwidth sharing in both the time and frequency domain is possible without interference between users. The invention details how all clocked components in the network are synchronised such that no clock offset compensation is required anywhere in the network. Also the present invention discloses a method for optimisation of the synchronous clocking method to maximise the system bit error rate (BER) performance, furthermore the present invention discloses a method for implementing multiband-OOFDM where ONUs can easily select any OOFDM band for data reception providing network configuration flexibility.

Abstract: The present invention discloses the use of a semiconductor optical amplifier in a transceiver in order to increase the number of end users without reducing the bandwidth allocated to each user.

Abstract: The present invention discloses a synchronisation method suitable for increasing the receiving speed in the receiving part of an orthogonal optical frequency division multiplexing (OOFDM) transceiver.

Abstract: The present invention relates to the field of signal transmission using orthogonal optical frequency division multiplexing transceivers and to the use of the same set of wavelengths for the downlink and uplink signal transmission.

Abstract: A composition and process are provided for predicting the responsiveness of an individual to therapy for a pathological condition is based on detecting nucleic acid allele sequences in an interleukin-10 regulatory region or cytotoxic t-lymphocyte antigen-4 promoter or exon region of the individual. The detected nucleic acid allele is then associated with the level of therapeutic responsiveness to a pathological condition based upon genotype. Comparison across multiple alleles and regions improves the predictive nature of the process.

Abstract: The present invention provides methods of correlating genetic variants in the beta-chemokine receptor 5 (CCR5) locus, more specifically CCR5 promoter alleles and genotypes, with HIV-1 transmission and/or disease progression in individuals and populations.