Abstract: The present invention belongs to the medical field, and relates to novel ?-lactamase inhibitors, for the treatment of bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I): or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: Use of Cistanche deserticola polysaccharide (CDP) in promoting the proliferation and differentiation of female germline stem cells (FGSCs) is provided. Specifically, the addition of CDP in an in vitro cultivation system can promote the proliferation and differentiation of FGSCs, and especially can enhance the in vitro directed differentiation of FGSCs into oocytes, which provides a new research reference for studying the generation of oocytes in vivo and in vitro and also brings a new hope for research on physiological infertility.

Abstract: ?-lactamase inhibitors, pharmaceutical compositions including the same, methods of preparing the same, and methods of treating bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I) or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: A monobactam compound of formula (I), a preparation thereof, and a use thereof as antibiotic agents for the treatment of bacterial infections are provided. In the formula (I), M is hydrogen or a pharmaceutically acceptable salt forming cation, R1 and R2 represent independently of one another hydrogen or methyl, W represents a bond or O, X represents CR4 or N, R4 represents halogen, R3 represents hydrogen, amino, hydroxy, (C1-C6)-alkyl, or a 4-, 5- or 6-membered nitrogen-containing heterocycle.

Abstract: An illumination system for a STED optical microscope includes an illumination light path consisting of an illumination light source and an optical elements. The illumination light path includes a first light filter, a second light filter, a polarizing light splitter, a first quarter wave plate, a first dichroic element, a light path delay unit, a phase plate, a second dichroic element, and a second quarter wave plate arranged in sequence along the transmission direction of the light path. The light beam emitted from the illumination light source is divided into two coaxial light beams after transmitted by the illumination light path. A first light beam is incident to a microscope objective to form a first light spot, a second light beam is incident to the microscope objective to form a second light spot, and the center of the first light spot coincides with that of the second light spot.

Abstract: Provided are ?-lactam compounds of formula (I), their preparation and use as antibiotic agents for the treatment of bacterial infections: Wherein X, W, R1, R2 and R3 are defined herein.

Abstract: A self-sensing and separated dual-cylinder magnetorheological damper includes a first piston cylinder and a second piston cylinder which are in angular communication with each other. The first piston cylinder includes a piston inner cylinder and a piston outer cylinder which together with the second piston cylinder form a magnetorheological fluid circulation channel. The piston inner cylinder is provided with a piston rod assembly reciprocating in an axial direction of the piston inner cylinder, and when the piston rod assembly is compressed and restored, the magnetorheological liquid correspondingly forms a first circulation loop and a second circulation loop respectively. The second piston cylinder is provided therein with a magnetorheological liquid adjustment mechanism for forming the first circulation loop and the second circulation loop.

Abstract: Use of Cistanche deserticola polysaccharide (CDP) in promoting the proliferation and differentiation of female germline stem cells (FGSCs) is provided. Specifically, the addition of CDP in an in vitro cultivation system can promote the proliferation and differentiation of FGSCs, and especially can enhance the in vitro directed differentiation of FGSCs into oocytes, which provides a new research reference for studying the generation of oocytes in vivo and in vitro and also brings a new hope for research on physiological infertility.

Abstract: An illumination system for a STED optical microscope includes an illumination light path consisting of an illumination light source and an optical element. The illumination light path includes a first light filter, a second light filter, a polarizing light splitter, a first quarter wave plate, a first dichroic element, a light path delay unit, a phase plate, a second dichroic element, and a second quarter wave plate arranged in sequence along the transmission direction of the light path. The light beam emitted from the illumination light source is divided into two coaxial light beams after transmitted by the illumination light path. A first light beam is incident to a microscope objective to form a first light spot, a second light beam 12 is incident to the microscope objective to form a second light spot, and the center of the first light spot coincides with that of the second light spot.

Abstract: Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.

Abstract: Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.