Abstract: A use of a polypeptide in a drug for preventing and treating pneumonia is provided. The polypeptide may effectively prevent and treat pneumonia, and may also be added with another therapeutic agent, excipient, carrier, or auxiliary ingredient to prepare a drug with the polypeptide and the therapeutic agent as main active ingredients for preventing and treating pneumonia. The present invention further discloses a use of the polypeptide and a drug thereof in prevention and treatment of pneumonia. The drug has good inhibitory and treatment effects on pneumonia, may effectively act on pneumonia caused by pathogenic bacteria for effective prevention, and may also improve a treatment effect on pneumonia. Compared with the prior art, the polypeptide and the drug thereof have effects of high safety and no drug resistance, can effectively prevent and treat pneumonia, and have high-value application prospects.

Abstract: An application of a polypeptide in preparing a composition for preventing and treating human papillomavirus infection, and a polypeptide composition for preventing and treating human papillomavirus infection are provided. The polypeptide composition is prepared by taking an effective dose of the polypeptide as an active ingredient, and adding a pharmaceutically acceptable adjuvant or auxiliary ingredient. The polypeptide of the present invention can be used for the treatment and prevention of human papillomavirus infection, having significant effect, no inhibitory effect on the normal flora of the female genital tract, and showing good safety.

Abstract: Disclosed are methods for suppressing or altering gene expression by locked nucleic acids that have high binding affinity for target sequences in genomic DNA. The present methods include a step of recombination to insert a foreign DNA fragment into a specific target site in a genome with greater efficiency than with current techniques. Using a protein to anchor a locked nucleic acid targeting construct at a specific site, DNA recombination between that site and foreign DNA is induced by employing the cell's innate repair machinery. As a result of this recombination, gene transcription can be effectively suppressed. The present methods work in all mammalian cells, and provide a rapid methodology to examine gene function. The foreign DNA can carry markers for ease of screening. The technique is applied in the production of stable cell lines with inserted or deleted genes.