Abstract: A method for combining a first liquid component with a second lyo component in a drug mixing apparatus is provided. The method comprises displacing a seal that prevents the first liquid component within a first barrel from coming into contact with the second lyo/liquid component within a second barrel. The method also comprises using an activating mechanism to move the first liquid component from the first barrel through at least one communication channel to an area within the second barrel holding the second lyo component, allowing the first liquid component to mix with the second lyo component to form a medicament. Additionally the method comprises displacing a second seal that prevents a medicament from entering an outlet channel. The method also comprises using the activating mechanism to eject the mixed medicament from the drug mixing apparatus through the outlet channel.

Abstract: A minimal pain microneedle based transdermal drug delivery device and method. The device has a clamshell configuration, where the top part of the clamshell holds one or more chambers configured to store liquid drugs, and also configured to store one or more spring operated plungers, and at least one microneedle. The top portion of the device is attached to the bottom portion of the device by a combination hinge and a moveable shutter mechanism. In its shut position, the shutter mechanism prevents the plungers from moving, and the open shutter position releases the plunger. When the user applies the bottom of the device to the user's skin and presses on the top portion with enough force to overcome a detent mechanism, the top portion pivots against the bottom portion forcing the microneedle through an aperture and into the skin painlessly. Pressing on the shutter mechanism then results in drug self-administration.